Correlation Between Tenofovir Drug Levels and the Renal Biomarkers RBP-4 and ß2M in the ION-4 Study Cohort.


Background:Concomitant dosing of ledipasvir (LDV) and tenofovir disoproxil fumarate (TDF) results in an increased tenofovir (TFV) area under the curve (AUC). The aim of this study was to examine whether there was a correlation between the renal biomarkers retinol binding protein-4 (RBP-4) and β2 microglobulin (β2M) and tenofovir AUC. Methods:The ION-4 trial enrolled HIV/hepatitis C virus-coinfected patients on nonpharmacologically boosted antiretroviral regimens with TDF-containing backbones. We assessed for a correlation between tenofovir AUC and urinary biomarkers and also for changes in serologic biomarkers with respect to clinically relevant changes in renal function (creatinine clearance decrease >25%, change in creatinine >0.2 mg/dL, change in proteinuria from negative/trace to ≥1+). Results:Three hundred thirty-five patients were enrolled in the ION-4 study; their demographic characteristics have been previously described. Both RBP-4 and β2M exhibited positive correlations with tenofovir AUC. Baseline and study levels of RBP-4 and β2M were higher for patients with increases in urine proteinuria and an absolute creatinine increase. Conclusions:TFV exposure is associated with increased proximal tubule urine biomarkers in participants on ledipasvir/sofosbuvir and nonpharmacologically boosted TDF-based antiretroviral regimens. Baseline proximal tubule biomarkers may predict nephrotoxicity risk if events are prevalent. Further studies assessing the predictive role of these urine biomarkers may help guide medical decision-making and risk/benefit assessments in patients with risk factors for renal dysfunction.


Open Forum Infect Dis


Chan A,Park L,Collins LF,Cooper C,Saag M,Dieterich D,Sulkowski M,Naggie S




Has Abstract


2019-01-24 00:00:00












  • Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.

    abstract::In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophag...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A

    更新日期:2019-09-30 00:00:00

  • Multiple Influenza Virus Infections in 4 Consecutive Epidemiological Seasons: A Retrospective Study in Children and Adolescents.

    abstract:Background:Recent observations provide evidence for group-specific immunity toward influenza A infections and raise the question of how often we can get the flu. Methods:We retrospectively analyzed 2308 cases of children and adolescents with clinically manifested influenza and a positive PCR-test during the last 4 epi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Möst J,Redlberger-Fritz M,Weiss G

    更新日期:2019-04-23 00:00:00

  • Control of a Nosocomial Outbreak of COVID-19 in a University Hospital.

    abstract:Background:Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective co...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Harada S,Uno S,Ando T,Iida M,Takano Y,Ishibashi Y,Uwamino Y,Nishimura T,Takeda A,Uchida S,Hirata A,Sata M,Matsumoto M,Takeuchi A,Obara H,Yokoyama H,Fukunaga K,Amagai M,Kitagawa Y,Takebayashi T,Hasegawa N

    更新日期:2020-10-22 00:00:00

  • Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler.

    abstract::Despite the widespread outbreak, few cases of Zika virus associated with cardiac manifestations have been described. We present a case of pericarditis in the setting of an acute, symptomatic Zika virus infection in a traveler returning from St. Thomas. Clinicians should be alert for this potential complication of Zika...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Waggoner JJ,Rouphael N,Xu Y,Natrajan M,Lai L,Patel SM,Levit RD,Edupuganti S,Mulligan MJ

    更新日期:2017-05-18 00:00:00

  • Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study.

    abstract:Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

    更新日期:2020-11-04 00:00:00

  • Soluble Tumor Necrosis Factor-α Receptor 2 in Urine Is a Potential Biomarker for Noninvasive Diagnosis of Malaria During Pregnancy.

    abstract::Background.  During pregnancy, the placenta is inaccessible for diagnosis of placental malaria (PM), but soluble tumor necrosis factor-α receptors (sTNFR) are elevated in the plasma of women with PM. Methods.  In this study, sTNFR-1 and sTNFR-2 were quantified in urine of pregnant and nonpregnant Cameroonian women who...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tassi Yunga S,Thévenon AD,Leke RG,Taylor DW

    更新日期:2016-04-26 00:00:00

  • Perspectives of Physician and Pharmacist Stewards on Successful Antibiotic Stewardship Program Implementation: A Qualitative Study.

    abstract:Background:Antibiotic stewardship programs (ASPs) are required at every hospital regardless of size. We conducted a qualitative study across different hospital settings to examine perspectives of physician and pharmacist stewards about the dynamics within their team and contextual factors that facilitate the success of...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Barlam TF,Childs E,Zieminski SA,Meshesha TM,Jones KE,Butler JM,Damschroder LJ,Goetz MB,Madaras-Kelly K,Reardon CM,Samore MH,Shen J,Stenehjem E,Zhang Y,Drainoni ML

    更新日期:2020-06-15 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract::Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期:2016-02-08 00:00:00

  • Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism.

    abstract:Background:We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells undergo metabolic changes to maintain their e...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kruize Z,Maurer I,van Dort KA,van den Elshout MAM,Hoornenborg E,Booiman T,Prins M,Kootstra NA

    更新日期:2020-07-05 00:00:00

  • Artificial Intelligence Platform Demonstrates High Adherence in Patients Receiving Fixed-Dose Ledipasvir and Sofosbuvir: A Pilot Study.

    abstract::This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

    更新日期:2020-07-20 00:00:00

  • Eight-Year-Old Male With Primary Amebic Meningoencephalitis.

    abstract::Naegleria fowleri is a thermophilic free-living amoeba that is found in warm, fresh water and causes primary amebic meningoencephalitis (PAM). The following report demonstrates the rapid and destructive clinical features of PAM in an 8-year-old male who presented with severe headaches approximately 12 days after swimm...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Vareechon C,Tarro T,Polanco C,Anand V,Pannaraj PS,Dien Bard J

    更新日期:2019-07-29 00:00:00

  • Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort.

    abstract:Background:There are few longitudinal data on the risk factors and mediators of racial disparities in sepsis among community- dwelling US adults. Methods:This is a longitudinal study of adult participants in the 1999-2005 National Health Interview Survey with data linked to the 1999-2011 National Death Index. We utili...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kempker JA,Kramer MR,Waller LA,Martin GS

    更新日期:2018-11-15 00:00:00

  • Gastrointestinal Events in High-Dose vs Standard-Dose Influenza Vaccine Recipients.

    abstract::Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Talbot HK,Dunning AJ,Robertson CA,Landolfi VA,Greenberg DP,DiazGranados CA

    更新日期:2018-05-22 00:00:00

  • Recombinant Human Plasma Gelsolin Improves Survival and Attenuates Lung Injury in a Murine Model of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia.

    abstract:Background:Plasma gelsolin (pGSN) is an abundant circulating protein quickly consumed by extensive tissue damage. Marked depletion is associated with later poor outcomes in diverse clinical circumstances. Repletion with recombinant human (rhu)-pGSN in animal models of inflammation lessens mortality and morbidity. Meth...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: DiNubile MJ,Levinson SL,Stossel TP,Lawrenz MB,Warawa JM

    更新日期:2020-06-19 00:00:00

  • In Utero ART Exposure and Birth and Early Growth Outcomes Among HIV-Exposed Uninfected Infants Attending Immunization Services: Results From National PMTCT Surveillance, South Africa.

    abstract:BACKGROUND:Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestationa...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ramokolo V,Goga AE,Lombard C,Doherty T,Jackson DJ,Engebretsen IM

    更新日期:2017-08-30 00:00:00

  • Public Awareness of Sepsis Is Low in Sweden.

    abstract::Background.  Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods.  A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results.  A total of 1001 ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Mellhammar L,Christensson B,Linder A

    更新日期:2015-10-26 00:00:00

  • Faces of Resistance: Using Real-World Patients and Their Advocates to Teach Medical Students About Antimicrobial Stewardship.

    abstract::We engaged medical students with antimicrobial stewardship (AS) and antimicrobial resistance (AMR) through patient stories and a panel on AMR advocacy with experts from the Centers for Disease Control and Prevention and the Infectious Diseases Society of America. Students were surveyed on their perceptions about AS an...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Nori P,Cowman K,Jezek A,Nosanchuk JD,Slosar-Cheah M,Sarwar U,Bartash R,Ostrowsky B

    更新日期:2019-11-13 00:00:00

  • Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis.

    abstract:Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ahmadpour E,Foroutan-Rad M,Majidiani H,Moghaddam SM,Hatam-Nahavandi K,Hosseini SA,Rahimi MT,Barac A,Rubino S,Zarean M,Mathioudakis AG,Cevik M

    更新日期:2019-06-11 00:00:00

  • Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections.

    abstract::Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for a...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Crum-Cianflone NF,Lam PV,Ross-Walker S,Rosen LB,Holland SM

    更新日期:2017-10-05 00:00:00

  • Lack of Awareness of Human Immunodeficiency Virus (HIV) Infection: Problems and Solutions With Self-reported HIV Serostatus of Men Who Have Sex With Men.

    abstract:BACKGROUND:Lack of human immunodeficiency virus (HIV) infection awareness may be a driver of racial disparities in HIV infection among men who have sex with men (MSM). Lack of awareness is typically measured by comparing HIV test result to self-reported HIV status. This measure may be subject to reporting bias and alte...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sanchez TH,Kelley CF,Rosenberg E,Luisi N,O'Hara B,Lambert R,Coleman R,Frew P,Salazar LF,Tao S,Clarke W,Del Rio C,Sullivan PS

    更新日期:2014-09-13 00:00:00

  • Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia.

    abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gutierrez J,Guimaraes AO,Lewin-Koh N,Berhanu A,Xu M,Cao Y,Kim J,Yan D,Chang JK,Dinoso JB,Koss CA,Clemenzi-Allen A,Chambers HF,Peck MC,Baruch A,Rosenberger CM

    更新日期:2019-02-26 00:00:00

  • West Nile Virus Central Nervous System Infection in Patients Treated With Rituximab: Implications for Diagnosis and Prognosis, With a Review of Literature.

    abstract::The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory resp...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morjaria S,Arguello E,Taur Y,Sepkowitz K,Hatzoglou V,Nemade A,Rosenblum M,Cavalcanti MS,Palomba ML,Kaltsas A

    更新日期:2015-09-19 00:00:00

  • Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

    abstract:Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced in...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

    更新日期:2020-07-02 00:00:00

  • Changes in Waist Circumference in HIV-Infected Individuals Initiating a Raltegravir or Protease Inhibitor Regimen: Effects of Sex and Race.

    abstract:Background:This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size. Methods:We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 ant...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bhagwat P,Ofotokun I,McComsey GA,Brown TT,Moser C,Sugar CA,Currier JS

    更新日期:2018-11-16 00:00:00

  • Treatment Options for Carbapenem-Resistant Enterobacteriaceae Infections.

    abstract::This article provides a comprehensive review of currently available treatment options for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance in Gram-negative bacteria is an emerging and serious global public health threat. Carbapenems have been used as the "last-line" treatment f...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Morrill HJ,Pogue JM,Kaye KS,LaPlante KL

    更新日期:2015-05-05 00:00:00

  • Sofosbuvir-Based Direct-Acting Antiviral Therapies for HCV in People Receiving Opioid Substitution Therapy: An Analysis of Phase 3 Studies.

    abstract:Background:Hepatitis C virus (HCV) direct-acting antiviral therapy is effective among people receiving opioid substitution therapy (OST), but studies are limited by small numbers of nongenotype 1 (GT1) patients. The aim of this study was to evaluate the treatment completion, adherence, SVR12, and safety of sofosbuvir-b...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Grebely J,Feld JJ,Wyles D,Sulkowski M,Ni L,Llewellyn J,Mir HM,Sajed N,Stamm LM,Hyland RH,McNally J,Brainard DM,Jacobson I,Zeuzem S,Bourlière M,Foster G,Afdhal N,Dore GJ

    更新日期:2018-02-09 00:00:00

  • PrEP Nonadherence, White Coat Dosing, and HIV Risk Among a Cohort of MSM.

    abstract::Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Blair CS,Beymer MR,Kofron RM,Bolan RK,Jordan WC,Haubrich RH,Wohl AR,Landovitz RJ

    更新日期:2020-08-07 00:00:00

  • Analytical Performance of the Exacto Test HIV Self-Test: A Cross-Sectional Field Study in the Democratic Republic of the Congo.

    abstract::The Democratic Republic of the Congo (DRC) has begun implementing HIV self-testing to boost the first "95" of the UNAIDS 95-95-95 targets by 2025. This study aims to assess the performance and usability of the Exacto Test HIV (Biosynex, Strasbourg, France) self-test in the lab and in the field. The Exacto Test HIV sel...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tonen-Wolyec S,Muwonga Masidi J,Kamanga Lukusa LF,Nsiku Dikumbwa G,Sarassoro A,Bélec L

    更新日期:2020-11-29 00:00:00

  • A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy.

    abstract:BACKGROUND:Immune activation persists despite suppressive antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infection and predicts non-Acquired Immune Deficiency Syndrome (AIDS) comorbidities including cardiovascular disease. Activated platelets play a key role in atherothrombosis and inflammation, and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: O'Brien MP,Hunt PW,Kitch DW,Klingman K,Stein JH,Funderburg NT,Berger JS,Tebas P,Clagett B,Moisi D,Utay NS,Aweeka F,Aberg JA

    更新日期:2017-01-19 00:00:00

  • Erratum.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofx156.][This corrects the article DOI: 10.1093/ofid/ofx156.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误



    更新日期:2018-01-30 00:00:00