Correlation Between Tenofovir Drug Levels and the Renal Biomarkers RBP-4 and ß2M in the ION-4 Study Cohort.

abstract：BACKGROUND:Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. METHODS:A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks' ges...

journal_title：Open forum infectious diseases

authors： Rick AM,Aguilar A,Cortes R,Gordillo R,Melgar M,Samayoa-Reyes G,Frank DN,Asturias EJ

更新日期：2017-02-08 00:00:00

abstract：Background:Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug susceptibilities, and outcomes of multiple-dose fosfomycin episodes for ou...

journal_title：Open forum infectious diseases

authors： Derington CG,Benavides N,Delate T,Fish DN

更新日期：2020-01-29 00:00:00

abstract：:Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

journal_title：Open forum infectious diseases

authors： Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

更新日期：2019-11-19 00:00:00

abstract：Background:Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive subs...

journal_title：Open forum infectious diseases

authors： Hanke K,Fiedler S,Grumann C,Ratmann O,Hauser A,Klink P,Meixenberger K,Altmann B,Zimmermann R,Marcus U,Bremer V,Auwärter V,Bannert N

更新日期：2020-05-27 00:00:00

abstract：Background:Rates of hepatitis C virus (HCV) among women of childbearing age have increased as a result of the opioid epidemic, especially in the nonurban white population. Recently updated US Preventative Services Task Force and Centers for Disease Control and Prevention guidance have recommended universal HCV screenin...

journal_title：Open forum infectious diseases

authors： Kushner T,Park C,Masand D,Wagner B,Grace M,Rosenbluth E,Rodriquez-Rivas C,de la Cruz H,Overbey J,Sperling R

更新日期：2020-10-23 00:00:00

abstract：:The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

journal_title：Open forum infectious diseases

authors： Gomez CA,Pinsky BA,Liu A,Banaei N

更新日期：2016-12-07 00:00:00

abstract：Background:Antimicrobial stewardship interventions utilizing real-time alerting through the electronic medical record enable timely implementation of the bundle of care (BOC) for patients with severe infections, such as candidemia. Automated alerting for candidemia using the Epic stewardship module has been in place si...

journal_title：Open forum infectious diseases

authors： Pettit NN,Han Z,Nguyen CT,Choksi A,Charnot-Katsikas A,Beavis KG,Tesic V,Pisano J

更新日期：2019-10-11 00:00:00

abstract：:Vancomycin is commonly added as empiric therapy for febrile neutropenia. A retrospective chart review was conducted at a large community teaching institution to evaluate vancomycin use in oncology patients. The results revealed that a majority of empiric vancomycin therapy was inappropriate, raising concern for antibi...

journal_title：Open forum infectious diseases

authors： Libuit J,Whitman A,Wolfe R,Washington CS

更新日期：2014-04-10 00:00:00

abstract：Background:Although existing literature supports durations of 5-7 days for skin and soft tissue infections (SSTIs), longer durations are commonly used. Obesity and heart failure (HF) have been associated with increased risk for treatment failure of SSTIs; however, whether prolonged antibiotic durations reduce the risk ...

journal_title：Open forum infectious diseases

authors： Ihm C,Sutton JD,Timbrook TT,Spivak ES

更新日期：2019-05-07 00:00:00

abstract：Background:US hematopoietic cell transplantation (HCT) recipients have a low prevalence of latent tuberculosis infection (LTBI), but if latently infected they are at risk for progression to active tuberculosis. At our center, all HCT recipients underwent LTBI testing pretransplant by tuberculin skin testing (TST) until...

journal_title：Open forum infectious diseases

authors： Sosa-Moreno A,Narita M,Spitters C,Swetky M,Podczervinski S,Lind ML,Holmberg L,Liu C,Edelstein R,Pergam SA

更新日期：2020-06-10 00:00:00

abstract：Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study w...

journal_title：Open forum infectious diseases

authors： Mücke MM,Mücke VT,Peiffer KH,Sarrazin C,Zeuzem S,Berger A,Vermehren J

更新日期：2018-12-15 00:00:00

abstract：Background:Patients with suspected tuberculosis are often overtreated with antituberculosis drugs. We evaluated the diagnostic value of the focused assessment with sonography for HIV-associated tuberculosis (FASH) in rural Tanzania. Methods:In a prospective cohort study, the frequency of FASH signs was compared betwee...

journal_title：Open forum infectious diseases

authors： Ndege R,Weisser M,Elzi L,Diggelmann F,Bani F,Gingo W,Sikalengo G,Mapesi H,Mchomvu E,Kamwela L,Mnzava D,Battegay M,Reither K,Paris DH,Rohacek M

更新日期：2019-04-25 00:00:00

abstract：:Background.  Histoplasmosis causes severe disease in patients with defects of cell-mediated immunity. It is not known whether outcomes vary related to the type of immunodeficiency or class of antifungal treatment. Methods.  We reviewed cases of active histoplasmosis that occurred at Vanderbilt University Medical Cente...

journal_title：Open forum infectious diseases

authors： Luckett K,Dummer JS,Miller G,Hester S,Thomas L

更新日期：2015-02-20 00:00:00

abstract：Background:The United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015-2016 mumps outbreak at the University of Iowa, we estimated the c...

journal_title：Open forum infectious diseases

authors： Marin M,Kitzmann TL,James L,Quinlisk P,Aldous WK,Zhang J,Cardemil CV,Galeazzi C,Patel M,Ortega-Sanchez IR

更新日期：2018-10-04 00:00:00

abstract：:Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

journal_title：Open forum infectious diseases

authors： Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

更新日期：2016-02-08 00:00:00

abstract：:A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by...

journal_title：Open forum infectious diseases

authors： Martin S,Balligand E,Peeters J,Nassogne MC,Mondovits B,Loop M,de Selys A,Vanclaire J,Vermylen C,De Bruyckere JJ,Chatzis O,Puel A,Gilliaux O,Van Der Linden D

更新日期：2019-11-03 00:00:00

abstract：Background:Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, we examined the effect of reported penicillin allergy on clinical outcomes in patients with MSSA bacteremia. Methods:In this retros...

journal_title：Open forum infectious diseases

authors： Turner NA,Moehring R,Sarubbi C,Wrenn RH,Drew RH,Cunningham CK,Fowler VG,Anderson DJ

更新日期：2018-02-19 00:00:00

abstract：:This article provides a comprehensive review of currently available treatment options for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance in Gram-negative bacteria is an emerging and serious global public health threat. Carbapenems have been used as the "last-line" treatment f...

journal_title：Open forum infectious diseases

authors： Morrill HJ,Pogue JM,Kaye KS,LaPlante KL

更新日期：2015-05-05 00:00:00

abstract：Background:The 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to adults aged ≥65 years. The study examines adults ≥65 years for risk of adverse events (AEs) requiring medical attention following vaccination with PCV13 as compared wit...

journal_title：Open forum infectious diseases

authors： Tseng HF,Sy LS,Qian L,Liu IA,Mercado C,Lewin B,Tartof SY,Nelson J,Jackson LA,Daley MF,Weintraub E,Klein NP,Belongia E,Liles EG,Jacobsen SJ

更新日期：2018-05-02 00:00:00

abstract：:We assessed the impact of a rapid molecular assay for influenza detection whether outsourced or performed onsite 24/7 in a University Hospital in Paris, France. Shorter median time-to-results (16.8 vs 2.3 hours, P < .05) and an increased rate of adequate prescription of oseltamivir (76.6% vs 95.3%, P < .05) were obser...

journal_title：Open forum infectious diseases

authors： Jacquier H,Péan de Ponfilly G,Chauvin A,Amarsy R,Benmansour H,Hoang-Nguyen DT,Lecorché E,Mesnil C,Mougari F,Munier AL,Salmona M,Berçot B,Le Goff J,Cambau E

更新日期：2020-08-25 00:00:00

abstract：:Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared with blood cultures. PubMed was searched for clinic...

journal_title：Open forum infectious diseases

authors： D'Onofrio V,Salimans L,Bedenić B,Cartuyvels R,Barišić I,Gyssens IC

更新日期：2020-08-13 00:00:00

abstract：:Both dengue virus (DENV) and hepatitis C virus (HCV) belong to the Flaviviridae family and could induce hepatitis. We aimed to investigate the interference between them. In total, 515 patients confirmed with dengue fever (DF) were enrolled. Thirty-two patients (6.21%) were seropositive for anti-HCV; 12 of 32 anti-HCV-...

journal_title：Open forum infectious diseases

authors： Liang PC,Chen KY,Huang CH,Chang K,Lu PL,Yeh ML,Huang CF,Huang CI,Hsieh MH,Dai CY,Lin ZY,Chen SC,Chuang WL,Chen YH,Huang JF,Yu ML

更新日期：2020-07-03 00:00:00

abstract：:Background.  Practicing antimicrobial stewardship in the setting of widespread antimicrobial resistance among gram-negative bacilli, particularly in urban areas, is challenging. Methods.  We conducted a retrospective cross-sectional study at a tertiary care hospital with an established antimicrobial stewardship progra...

journal_title：Open forum infectious diseases

authors： Vora NM,Kubin CJ,Furuya EY

更新日期：2015-02-19 00:00:00

abstract：:The Democratic Republic of the Congo (DRC) has begun implementing HIV self-testing to boost the first "95" of the UNAIDS 95-95-95 targets by 2025. This study aims to assess the performance and usability of the Exacto Test HIV (Biosynex, Strasbourg, France) self-test in the lab and in the field. The Exacto Test HIV sel...

journal_title：Open forum infectious diseases

authors： Tonen-Wolyec S,Muwonga Masidi J,Kamanga Lukusa LF,Nsiku Dikumbwa G,Sarassoro A,Bélec L

更新日期：2020-11-29 00:00:00

abstract：:Background.  First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of...

journal_title：Open forum infectious diseases

authors： Overton ET,Stapleton J,Frank I,Hassler S,Goepfert PA,Barker D,Wagner E,von Krempelhuber A,Virgin G,Meyer TP,Müller J,Bädeker N,Grünert R,Young P,Rösch S,Maclennan J,Arndtz-Wiedemann N,Chaplin P

更新日期：2015-05-05 00:00:00

abstract：:Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptom...

journal_title：Open forum infectious diseases

authors： Lehloenya RJ,Dlamini S,Muloiwa R,Kakande B,Ngwanya MR,Todd G,Dheda K

更新日期：2016-06-20 00:00:00

abstract：BACKGROUND:Among the 1.2 M persons living with HIV in the United States, 25% are co- infected with HCV. The availability of effective direct antiviral agents (DAAs) makes the goal of HCV elimination feasible, but implementation requires improvements to the HCV treatment cascade, especially linkage to and initiation of ...

journal_title：Open forum infectious diseases

authors： Rizk C,Miceli J,Shiferaw B,Malinis M,Barakat L,Ogbuagu O,Villanueva M

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS:We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, de...

journal_title：Open forum infectious diseases

authors： Pérez-Latorre L,Rivero-Juárez A,Hontañón V,Díez C,Cuenca F,Martín-Carbonero ML,Montes ML,Bellón JM,Aldámiz-Echevarría T,Carrero A,Rivero A,González-García J,Berenguer J

更新日期：2016-10-03 00:00:00

abstract：Background:Patients heterozygous for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more susceptible to respiratory infections than the general population. Methods :We conducted a retrospective case-control study using health insurance claims. We identified patients as either h...

journal_title：Open forum infectious diseases

authors： Polgreen PM,Brown GD,Hornick DB,Ahmad F,London B,Stoltz DA,Comellas AP

更新日期：2018-11-01 00:00:00

abstract：Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

journal_title：Open forum infectious diseases

authors： Jung S,Sexton ME,Owens S,Spell N,Fridkin S

更新日期：2019-01-18 00:00:00