Abstract：
BACKGROUND:The small population of glioma stem-like cells (GSCs) contributes to tumor initiation, malignancy, and recurrence in glioblastoma. However, the maintenance of GSC properties in the tumor microenvironment remains unclear. In glioma, non-neoplastic cells create an inflammatory environment and subsequently mediate tumor progression and maintenance. Transcriptional factor CCAAT/enhancer-binding protein delta (CEBPD) is suggested to regulate various genes responsive to inflammatory cytokines, thus prompting us to investigate its role in regulating GSCs stemness after inflammatory stimulation. METHODS:Stemness properties were analyzed by using spheroid formation. Oncomine and TCGA bioinformatic databases were used to analyze gene expression. Western blotting, quantitative real-time polymerase chain reaction, luciferase reporter assay, and chromatin immunoprecipitation assay were used to analyze proteins and gene transcript levels. The glioma tissue microarrays were used for CEBPD and PDGFA expression by immunohistochemistry staining. RESULTS:We first found that IL-1β promotes glioma spheroid formation and is associated with elevated CEBPD expression. Using microarray analysis, platelet-derived growth factor subunit A (PDGFA) was confirmed as a CEBPD-regulated gene that mediates IL-1β-enhanced GSCs self-renewal. Further analysis of the genomic database and tissue array revealed that the expression levels between CEBPD and PDGFA were coincident in glioma patient samples. CONCLUSION:This is the first report showing the activation of PDGFA expression by CEBPD through IL-1β treatment and a novel CEBPD function in maintaining the self-renewal feature of GSCs.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ,Ko CYdoi
10.1186/s12974-019-1535-zsubject
Has Abstractpub_date
2019-07-12 00:00:00pages
146issue
1issn
1742-2094pii
10.1186/s12974-019-1535-zjournal_volume
16pub_type
杂志文章abstract：BACKGROUND:Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity i...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-017-0889-3
更新日期：2017-06-08 00:00:00
abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0663-y
更新日期：2016-08-25 00:00:00
abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-10-153
更新日期：2013-12-17 00:00:00
abstract：BACKGROUND:The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1326-y
更新日期：2018-10-15 00:00:00
abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0297-5
更新日期：2015-04-18 00:00:00
abstract：BACKGROUND:Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks colony-stimulating factor-1 (CSF-1) and thus has a deficiency in microglia and macrophages. Prior reports ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-4-31
更新日期：2007-12-20 00:00:00
abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0538-2
更新日期：2016-04-07 00:00:00
abstract：BACKGROUND:Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induction of depression-like behaviors in animal models. Several studies hav...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0563-1
更新日期：2016-05-03 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles, and prominent neuroinflammation. Recently, interference with neuroinflammation as a new therapeutic approach for AD treatment gained great interest. ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0369-6
更新日期：2015-08-16 00:00:00
abstract：:Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-016-0774-5
更新日期：2017-01-23 00:00:00
abstract：BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-63
更新日期：2014-03-29 00:00:00
abstract：:Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01975-2
更新日期：2020-10-22 00:00:00
abstract：:Nerve injury-induced chronic pain has been an urgent problem for both public health and clinical practice. While transition to chronic pain is not an inevitable consequence of nerve injuries, the susceptibility/resilience factors and mechanisms for chronic neuropathic pain after nerve injuries still remain unknown. Cu...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-019-1684-0
更新日期：2020-01-03 00:00:00
abstract：BACKGROUND:Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases. Autoimmunity may have a role in the pathogenesis of autism in ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-8-180
更新日期：2011-12-21 00:00:00
abstract：:The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response. In addition, some of the early components of this cascade have been clea...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-020-02024-8
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells). Thus, a strict separation between the two T cell subsets in the context of experimental ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-02021-x
更新日期：2020-11-26 00:00:00
abstract：:BACKGROUND: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability t...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-1-17
更新日期：2004-08-24 00:00:00
abstract：BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-02062-2
更新日期：2021-01-09 00:00:00
abstract：BACKGROUND:Persistent systemic infection results in excessive trafficking of peripheral immune cells into the central nervous system (CNS), thereby contributing to sustained neuroinflammation that leads to neurocognitive deficits. In this study, we explored the role of opportunistic systemic infection with Streptococcu...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0341-5
更新日期：2015-06-20 00:00:00
abstract：BACKGROUND:Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potentia...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0452-z
更新日期：2015-12-21 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Journal of neuroinflammation
pub_type： 已发布勘误
doi：10.1186/s12974-020-01990-3
更新日期：2020-11-24 00:00:00
abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-8-105
更新日期：2011-08-24 00:00:00
abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0611-x
更新日期：2016-06-22 00:00:00
abstract：:The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome is a member of the NLR family of innate immune cell sensors. These are crucial regulators of cytokine secretions, which promote ischemic cell death and insulin resistance. This review summarizes rece...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-019-1498-0
更新日期：2019-06-07 00:00:00
abstract：BACKGROUND:Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and in...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1576-3
更新日期：2019-09-30 00:00:00
abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0632-5
更新日期：2016-06-30 00:00:00
abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1112-x
更新日期：2018-03-12 00:00:00
abstract：:Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic pain accelerates AD pathogenesis. In this review, we provide evidence th...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-019-1608-z
更新日期：2019-11-06 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects of oligodendrocytes in neurodegenerative diseases, it remains unknown whether ol...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1415-6
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1653-7
更新日期：2020-01-03 00:00:00
