Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model.

Abstract:

BACKGROUND:Persistent systemic infection results in excessive trafficking of peripheral immune cells into the central nervous system (CNS), thereby contributing to sustained neuroinflammation that leads to neurocognitive deficits. In this study, we explored the role of opportunistic systemic infection with Streptococcus pneumoniae in the recruitment of peripheral leukocytes into the CNS and its contribution to HIV-1-associated neurocognitive disorders in opioid-dependent individuals. METHODS:Wild-type B6CBAF1 (wt), μ-opioid receptor knockout (MORKO), FVB/N luciferase transgenic, and Toll-like receptor 2 and 4 knockout (TLR2KO and TLR4KO) mice were subcutaneously implanted with morphine/placebo pellet followed by HIV-1 Transactivator of transcription (Tat) protein injection intravenously and S. pneumoniae administration intraperitoneally. On postoperative day 5, brains perfused with phosphate-buffered saline were harvested and subjected to immunohistochemistry (for bacterial trafficking and chemokine ligand generation), flow cytometry (for phenotypic characterization of CNS trafficked immune cells), Western blot, and real-time PCR (for ligand expression). RESULTS:Our results show differential leukocyte trafficking of T lymphocytes (CD3+) and inflammatory monocytes (Ly6C+) into the CNS of mice treated with morphine, HIV-1 Tat, and/or S. pneumoniae. In addition, we demonstrate a Trojan horse mechanism for bacterial dissemination across the blood-brain barrier into the CNS by monocytes. Activation of TLRs on microglia induced a chemokine gradient that facilitated receptor-dependent trafficking of peripheral immune cells into the CNS. HIV-1 Tat induced trafficking of Ly6C+ and CD3+ cells into the CNS; infection with S. pneumoniae facilitated infiltration of only T lymphocytes into the CNS. We also observed differential chemokine secretion in the CNS, with CCL5 being the predominant chemokine following HIV-1 Tat treatment, which was potentiated further with morphine. S. pneumoniae alone led to preferential induction of CXCL12. Furthermore, we attributed a regulatory role for TLRs in the chemokine-mediated trafficking of leukocytes into the CNS. Chronic morphine and HIV-1 Tat, in the context of systemic S. pneumoniae co-infection, differentially modulated induction of TLR2/4, which consequently facilitated trafficking of TLR2 → CD3 + CCR5+ and TLR4 → Ly6C+(CCR5+/CXCR4+) immune cells into the CNS. CONCLUSION:Our murine study suggests that secondary infection in opioid-dependent individuals infected with HIV-1 augments peripheral leukocyte trafficking as a consequence of sustained chemokine gradients in the CNS.

journal_name

J Neuroinflammation

authors

Dutta R,Roy S

doi

10.1186/s12974-015-0341-5

subject

Has Abstract

pub_date

2015-06-20 00:00:00

pages

120

issn

1742-2094

pii

10.1186/s12974-015-0341-5

journal_volume

12

pub_type

杂志文章
  • Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation.

    abstract:BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-019-1544-y

    authors: Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

    更新日期:2019-07-19 00:00:00

  • Necrotizing enterocolitis is associated with acute brain responses in preterm pigs.

    abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1201-x

    authors: Sun J,Pan X,Christiansen LI,Yuan XL,Skovgaard K,Chatterton DEW,Kaalund SS,Gao F,Sangild PT,Pankratova S

    更新日期:2018-06-09 00:00:00

  • A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis.

    abstract:BACKGROUND:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduced neuroinflammation and severity of disease in an animal model of multiple sclerosis (MS), experime...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-64

    authors: Agrawal SM,Silva C,Wang J,Tong JP,Yong VW

    更新日期:2012-04-05 00:00:00

  • Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after stroke.

    abstract:BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0622-7

    authors: Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

    更新日期:2016-06-18 00:00:00

  • Prevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway.

    abstract:BACKGROUND:It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully unde...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-103

    authors: Coelho-Santos V,Gonçalves J,Fontes-Ribeiro C,Silva AP

    更新日期:2012-07-06 00:00:00

  • Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents.

    abstract::Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-01975-2

    authors: Doyle TM,Hutchinson MR,Braden K,Janes K,Staikopoulos V,Chen Z,Neumann WL,Spiegel S,Salvemini D

    更新日期:2020-10-22 00:00:00

  • Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice.

    abstract:BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0254-3

    authors: Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

    更新日期:2015-02-27 00:00:00

  • Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-11-59

    authors: Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

    更新日期:2014-03-27 00:00:00

  • Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

    abstract:BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-4-8

    authors: Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

    更新日期:2007-02-26 00:00:00

  • Distinct cytokine patterns may regulate the severity of neonatal asphyxia-an observational study.

    abstract:BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-017-1023-2

    authors: Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

    更新日期:2017-12-12 00:00:00

  • Compound 49b protects against blast-induced retinal injury.

    abstract:AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-10-96

    authors: Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

    更新日期:2013-07-30 00:00:00

  • Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice.

    abstract:BACKGROUND:Exposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer's disease (AD)-like pathological changes. However, it is largely unknown whether BaP exposure participates in the disease progression of AD. OBJECTIVES:To investigate the effect of BaP exposure on AD progression an...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-01925-y

    authors: Liu D,Zhao Y,Qi Y,Gao Y,Tu D,Wang Y,Gao HM,Zhou H

    更新日期:2020-08-31 00:00:00

  • Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment.

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS can start focally at a single...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审

    doi:10.1186/s12974-020-01849-7

    authors: Schram S,Loeb JA,Song F

    更新日期:2020-06-06 00:00:00

  • Association of social and cognitive impairment and biomarkers in autism spectrum disorders.

    abstract:OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-11-4

    authors: Alabdali A,Al-Ayadhi L,El-Ansary A

    更新日期:2014-01-08 00:00:00

  • Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis.

    abstract:BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-6-14

    authors: Das Sarma J,Ciric B,Marek R,Sadhukhan S,Caruso ML,Shafagh J,Fitzgerald DC,Shindler KS,Rostami A

    更新日期:2009-04-28 00:00:00

  • Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.

    abstract:BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-10-119

    authors: Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PG

    更新日期:2013-09-26 00:00:00

  • Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice.

    abstract:BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-8-23

    authors: Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

    更新日期:2011-03-09 00:00:00

  • The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease.

    abstract:BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-02062-2

    authors: Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

    更新日期:2021-01-09 00:00:00

  • Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation.

    abstract:BACKGROUND:Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer's disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD:In this study, we investigated Aβ-effects on heat s...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0304-x

    authors: Lamoke F,Mazzone V,Persichini T,Maraschi A,Harris MB,Venema RC,Colasanti M,Gliozzi M,Muscoli C,Bartoli M,Mollace V

    更新日期:2015-05-03 00:00:00

  • All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.

    abstract:BACKGROUND AND PURPOSE:Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neuroprotection remain elusive. ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-019-1557-6

    authors: Cai W,Wang J,Hu M,Chen X,Lu Z,Bellanti JA,Zheng SG

    更新日期:2019-08-31 00:00:00

  • Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.

    abstract:BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0412-7

    authors: Yshii LM,Denadai-Souza A,Vasconcelos AR,Avellar MC,Scavone C

    更新日期:2015-10-26 00:00:00

  • Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.

    abstract:BACKGROUND:The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1326-y

    authors: Davis SM,Collier LA,Winford ED,Leonardo CC,Ajmo CT Jr,Foran EA,Kopper TJ,Gensel JC,Pennypacker KR

    更新日期:2018-10-15 00:00:00

  • Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy.

    abstract:BACKGROUND:T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells). Thus, a strict separation between the two T cell subsets in the context of experimental ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-02021-x

    authors: Loos J,Schmaul S,Noll TM,Paterka M,Schillner M,Löffel JT,Zipp F,Bittner S

    更新日期:2020-11-26 00:00:00

  • Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-43

    authors: Byrnes KR,Loane DJ,Stoica BA,Zhang J,Faden AI

    更新日期:2012-02-28 00:00:00

  • Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression.

    abstract::Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审

    doi:10.1186/s12974-020-01732-5

    authors: Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

    更新日期:2020-02-12 00:00:00

  • Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

    abstract:BACKGROUND:There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS:We studied the HLA-B & C a...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-3-33

    authors: Lehmann DJ,Barnardo MC,Fuggle S,Quiroga I,Sutherland A,Warden DR,Barnetson L,Horton R,Beck S,Smith AD

    更新日期:2006-12-18 00:00:00

  • The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes.

    abstract:BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0728-y

    authors: Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

    更新日期:2016-10-04 00:00:00

  • Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition.

    abstract:BACKGROUND:Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. METHODS:A perioperative neurocognitive disorders (PND) mouse model was generated...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-01799-0

    authors: Li D,Chen M,Meng T,Fei J

    更新日期:2020-04-07 00:00:00

  • Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer's disease.

    abstract::Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审

    doi:10.1186/s12974-016-0525-7

    authors: Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

    更新日期:2016-03-10 00:00:00

  • Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis.

    abstract:BACKGROUND:Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through its NK1 receptor. Incr...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0453-y

    authors: Martinez AN,Ramesh G,Jacobs MB,Philipp MT

    更新日期:2015-12-30 00:00:00