Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion.

abstract：BACKGROUND:Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instruc...

journal_title：Journal of neuroinflammation

authors： Welser JV,Halder SK,Kant R,Boroujerdi A,Milner R

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) restores inflammatory immune responses in AIDS patients which may unmask previous subclinical infections or paradoxically exacerbate symptoms of opportunistic infections. In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune rec...

journal_title：Journal of neuroinflammation

authors： Mutnal MB,Schachtele SJ,Hu S,Lokensgard JR

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND AND PURPOSE:Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neuroprotection remain elusive. ...

journal_title：Journal of neuroinflammation

authors： Cai W,Wang J,Hu M,Chen X,Lu Z,Bellanti JA,Zheng SG

更新日期：2019-08-31 00:00:00

abstract：BACKGROUND:T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells). Thus, a strict separation between the two T cell subsets in the context of experimental ...

journal_title：Journal of neuroinflammation

authors： Loos J,Schmaul S,Noll TM,Paterka M,Schillner M,Löffel JT,Zipp F,Bittner S

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Osteopontin (OPN, SPP1) is upregulated in response to acute brain injury, and based on its immunoreactivity, two distinct forms have been identified: intracellular OPN within brain macrophages and small granular OPN, identified as OPN-coated degenerated neurites. This study investigates the spatiotemporal re...

journal_title：Journal of neuroinflammation

authors： Riew TR,Kim S,Jin X,Kim HL,Lee JH,Lee MY

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:The CD133(+) stem cell population in recurrent gliomas is associated with clinical features such as therapy resistance, blood-brain barrier disruption and, hence, tumor infiltration. Screening of a large panel of glioma samples increasing histological grade demonstrated frequencies of CD133(+) cells which co...

journal_title：Journal of neuroinflammation

authors： Annabi B,Laflamme C,Sina A,Lachambre MP,Béliveau R

更新日期：2009-03-09 00:00:00

abstract：BACKGROUND:MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are involved in neuropathic pain. ME...

journal_title：Journal of neuroinflammation

authors： Liu F,Wang Z,Qiu Y,Wei M,Li C,Xie Y,Shen L,Huang Y,Ma C

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Activation of inflammation pathways in the brain occurs in Alzheimer's disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute to tau protein accumulation an...

journal_title：Journal of neuroinflammation

authors： Bennett RE,Bryant A,Hu M,Robbins AB,Hopp SC,Hyman BT

更新日期：2018-11-09 00:00:00

abstract：BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

journal_title：Journal of neuroinflammation

authors： Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission o...

journal_title：Journal of neuroinflammation

authors： Yang S,Gao L,Lu F,Wang B,Gao F,Zhu G,Cai Z,Lai J,Yang Q

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...

journal_title：Journal of neuroinflammation

authors： Bahia El Idrissi N,Bosch S,Ramaglia V,Aronica E,Baas F,Troost D

更新日期：2016-04-07 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:While it is clear that inbred strains of mice have variations in immunological responsiveness, the influence of genetic background following tissue damage in the central nervous system is not fully understood. A cortical explant system was employed as a model for injury to determine whether the immediate tra...

journal_title：Journal of neuroinflammation

authors： Graber DJ,Harris BT,Hickey WF

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...

journal_title：Journal of neuroinflammation

authors： Hinojosa AE,Caso JR,García-Bueno B,Leza JC,Madrigal JL

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epilepsy after TBI is often resistant to existing anti-epileptic drugs. The development of post-traumati...

journal_title：Journal of neuroinflammation

authors： Webster KM,Sun M,Crack P,O'Brien TJ,Shultz SR,Semple BD

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pathway in ...

journal_title：Journal of neuroinflammation

authors： Hopp S,Nolte MW,Stetter C,Kleinschnitz C,Sirén AL,Albert-Weissenberger C

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...

journal_title：Journal of neuroinflammation

authors： Levesque S,Surace MJ,McDonald J,Block ML

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. Perivascular cuffing and clusters of T cells in the affected cortical hemisphere are indicative of an active cellular immune response. METHODS:Peripheral...

journal_title：Journal of neuroinflammation

authors： Owens GC,Erickson KL,Malone CC,Pan C,Huynh MN,Chang JW,Chirwa T,Vinters HV,Mathern GW,Kruse CA

更新日期：2015-07-19 00:00:00

abstract：BACKGROUND:Microglia/macrophages (MG/MΦ) are found in the subretinal space in both mice and humans. Our goal was to study the spatial and temporal distribution, the phenotype, and gene expression of subretinal MG/MΦ in mice with normal retinas and compare them to mice with known retinal pathology. METHODS:We studied C...

journal_title：Journal of neuroinflammation

authors： Aredo B,Zhang K,Chen X,Wang CX,Li T,Ufret-Vincenty RL

更新日期：2015-01-15 00:00:00

abstract：BACKGROUND:Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible factor which may contribute is interferon-γ (IFNγ). IFNγ h...

journal_title：Journal of neuroinflammation

authors： Lyons A,Murphy KJ,Clarke R,Lynch MA

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Brain microvascular pericytes are important constituents of the neurovascular unit. These cells are physically the closest cells to the microvascular endothelial cells in brain capillaries. They significantly contribute to the induction and maintenance of the barrier functions of the blood-brain barrier. How...

journal_title：Journal of neuroinflammation

authors： Kovac A,Erickson MA,Banks WA

更新日期：2011-10-13 00:00:00

abstract：BACKGROUND:Kainic acid (KA)-induced status epilepticus (SE) was involved with release of free radicals. Sesamin is a well-known antioxidant from sesame seeds and it scavenges free radicals in several brain injury models. However the neuroprotective mechanism of sesamin to KA-induced seizure has not been studied. METHO...

journal_title：Journal of neuroinflammation

authors： Hsieh PF,Hou CW,Yao PW,Wu SP,Peng YF,Shen ML,Lin CH,Chao YY,Chang MH,Jeng KC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...

journal_title：Journal of neuroinflammation

authors： Sun J,Pan X,Christiansen LI,Yuan XL,Skovgaard K,Chatterton DEW,Kaalund SS,Gao F,Sangild PT,Pankratova S

更新日期：2018-06-09 00:00:00

abstract：BACKGROUND:Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underl...

journal_title：Journal of neuroinflammation

authors： Yasui M,Menjyo Y,Tokizane K,Shiozawa A,Tsuda M,Inoue K,Kiyama H

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Conditions of inflammatory tissue distress are associated with high extracellular levels of adenosine, due to increased adenosine triphosphate (ATP) degradation upon cellular stress or the release of extracellular ATP upon cell death, which can be degraded to adenosine by membrane-bound ecto-enzymes like CD3...

journal_title：Journal of neuroinflammation

authors： Ingwersen J,Wingerath B,Graf J,Lepka K,Hofrichter M,Schröter F,Wedekind F,Bauer A,Schrader J,Hartung HP,Prozorovski T,Aktas O

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory reaction plays a crucial role in cerebral ischemia reperfusion (IR) injury. It has been shown that activated microglia long-term existed in cerebral ischemia and induced second injury. Therefore, we hypothesize that prepared phosphatidylserine (PS)-modified microbubbles (PS-MBs) comb...

journal_title：Journal of neuroinflammation

authors： Zhao R,Jiang J,Li H,Chen M,Liu R,Sun S,Ma,Liang X,Wang S

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. METHODS:Expression levels of proinflammatory cytokines were tested by QT-PCR and ELISA, levels of IDOs were...

journal_title：Journal of neuroinflammation

authors： Jiang X,Xu L,Tang L,Liu F,Chen Z,Zhang J,Chen L,Pang C,Yu X

更新日期：2018-01-04 00:00:00

abstract：:Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary infla...

journal_title：Journal of neuroinflammation

authors： Wang PF,Xiong XY,Chen J,Wang YC,Duan W,Yang QW

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. METHODS:A perioperative neurocognitive disorders (PND) mouse model was generated...

journal_title：Journal of neuroinflammation

authors： Li D,Chen M,Meng T,Fei J

更新日期：2020-04-07 00:00:00