你正在浏览Journal of Neuroinflammation期刊下所有文献
  • Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury.

    abstract:BACKGROUND:Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Dukay B,Walter FR,Vigh JP,Barabási B,Hajdu P,Balassa T,Migh E,Kincses A,Hoyk Z,Szögi T,Borbély E,Csoboz B,Horváth P,Fülöp L,Penke B,Vígh L,Deli MA,Sántha M,Tóth ME

    更新日期:2021-01-10 00:00:00

  • The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease.

    abstract:BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

    更新日期:2021-01-09 00:00:00

  • Differential neurovirulence of Usutu virus lineages in mice and neuronal cells.

    abstract:BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

    更新日期:2021-01-06 00:00:00

  • Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway.

    abstract:BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

    更新日期:2021-01-06 00:00:00

  • Immunological classification of gliomas based on immunogenomic profiling.

    abstract:BACKGROUND:Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. METHODS:We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Feng Q,Li L,Li M,Wang X

    更新日期:2020-11-27 00:00:00

  • Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy.

    abstract:BACKGROUND:T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells). Thus, a strict separation between the two T cell subsets in the context of experimental ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Loos J,Schmaul S,Noll TM,Paterka M,Schillner M,Löffel JT,Zipp F,Bittner S

    更新日期:2020-11-26 00:00:00

  • The good, the bad, and the opportunities of the complement system in neurodegenerative disease.

    abstract::The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response. In addition, some of the early components of this cascade have been clea...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审


    authors: Schartz ND,Tenner AJ

    更新日期:2020-11-25 00:00:00

  • Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Journal of neuroinflammation

    pub_type: 已发布勘误


    authors: Wang YW,Zhou Q,Zhang X,Qian QQ,Xu JW,Ni PF,Qian YN

    更新日期:2020-11-24 00:00:00

  • K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway.

    abstract:BACKGROUND:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cyclohexene-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanami...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Ham HJ,Lee YS,Yun J,Son DJ,Lee HP,Han SB,Hong JT

    更新日期:2020-11-22 00:00:00

  • Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

    更新日期:2020-11-12 00:00:00

  • Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model.

    abstract:BACKGROUND:Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE:This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reactive oxygen species (...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Chen M,Yang LL,Hu ZW,Qin C,Zhou LQ,Duan YL,Bosco DB,Wu LJ,Zhan KB,Xu SB,Tian DS

    更新日期:2020-11-06 00:00:00

  • Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents.

    abstract::Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Doyle TM,Hutchinson MR,Braden K,Janes K,Staikopoulos V,Chen Z,Neumann WL,Spiegel S,Salvemini D

    更新日期:2020-10-22 00:00:00

  • Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain.

    abstract:BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-gal...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Ullah R,Jo MH,Riaz M,Alam SI,Saeed K,Ali W,Rehman IU,Ikram M,Kim MO

    更新日期:2020-10-15 00:00:00

  • Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.

    abstract:BACKGROUND:Excessive inflammation might activate and injure the blood-brain barrier (BBB), a common feature of many central nervous system (CNS) disorders. We previously developed an in vitro BBB injury model in which the organophosphate paraoxon (PX) affects the BBB endothelium by attenuating junctional protein expres...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Israelov H,Ravid O,Atrakchi D,Rand D,Elhaik S,Bresler Y,Twitto-Greenberg R,Omesi L,Liraz-Zaltsman S,Gosselet F,Schnaider Beeri M,Cooper I

    更新日期:2020-09-09 00:00:00

  • Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis.

    abstract:BACKGROUND:Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS). The aim of the present study was to apprai...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Teixeira NB,Picolo G,Giardini AC,Boumezbeur F,Pottier G,Kuhnast B,Servent D,Benoit E

    更新日期:2020-09-07 00:00:00

  • Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice.

    abstract:BACKGROUND:Exposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer's disease (AD)-like pathological changes. However, it is largely unknown whether BaP exposure participates in the disease progression of AD. OBJECTIVES:To investigate the effect of BaP exposure on AD progression an...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Liu D,Zhao Y,Qi Y,Gao Y,Tu D,Wang Y,Gao HM,Zhou H

    更新日期:2020-08-31 00:00:00

  • Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration.

    abstract:BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

    更新日期:2020-08-10 00:00:00

  • The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome.

    abstract::Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), l...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审


    authors: Liu X,Ma Y,Ouyang R,Zeng Z,Zhan Z,Lu H,Cui Y,Dai Z,Luo L,He C,Li H,Zong D,Chen Y

    更新日期:2020-08-01 00:00:00

  • Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats.

    abstract:BACKGROUND:Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and anxiety. While neuroinflammation in the hypothalamic paraventricu...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Althammer F,Ferreira-Neto HC,Rubaharan M,Roy RK,Patel AA,Murphy A,Cox DN,Stern JE

    更新日期:2020-07-23 00:00:00

  • Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation.

    abstract:BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

    更新日期:2020-06-19 00:00:00

  • Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment.

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS can start focally at a single...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审


    authors: Schram S,Loeb JA,Song F

    更新日期:2020-06-06 00:00:00

  • Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson's disease model.

    abstract:BACKGROUND:The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in P...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Hou L,Qu X,Qiu X,Huang R,Zhao X,Wang Q

    更新日期:2020-05-06 00:00:00

  • PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study.

    abstract:BACKGROUND:Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Shrestha S,Kim MJ,Eldridge M,Lehmann ML,Frankland M,Liow JS,Yu ZX,Cortes-Salva M,Telu S,Henter ID,Gallagher E,Lee JH,Fredericks JM,Poffenberger C,Tye G,Ruiz-Perdomo Y,Anaya FJ,Montero Santamaria JA,Gladding RL,Zoghb

    更新日期:2020-05-02 00:00:00

  • LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3.

    abstract:BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

    更新日期:2020-04-28 00:00:00

  • Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis.

    abstract:BACKGROUND:The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to discover novel L-type voltag...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Saddala MS,Lennikov A,Mukwaya A,Yang Y,Hill MA,Lagali N,Huang H

    更新日期:2020-04-25 00:00:00

  • Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion.

    abstract:BACKGROUND:Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addit...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Leardini-Tristão M,Andrade G,Garcia C,Reis PA,Lourenço M,Moreira ETS,Lima FRS,Castro-Faria-Neto HC,Tibirica E,Estato V

    更新日期:2020-04-16 00:00:00

  • Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring.

    abstract:BACKGROUND:Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of b...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Wijenayake S,Rahman MF,Lum CMW,De Vega WC,Sasaki A,McGowan PO

    更新日期:2020-04-15 00:00:00

  • Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition.

    abstract:BACKGROUND:Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. METHODS:A perioperative neurocognitive disorders (PND) mouse model was generated...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Li D,Chen M,Meng T,Fei J

    更新日期:2020-04-07 00:00:00

  • Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model.

    abstract:BACKGROUND:Cannabinoid-2 receptor (CB2R) plays an important role in the cascading inflammation following ischemic injury. The toll-like receptors 4 (TLR4)/matrix metalloproteinase 9 (MMP9) signal pathway is involved in blood-brain barrier dysfunction induced by ischemia stroke. The aim of this study is to investigate t...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Jing N,Fang B,Li Z,Tian A

    更新日期:2020-04-06 00:00:00

  • Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.

    abstract:BACKGROUND:Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO). In a previous study, we showed that the PKO mice were grossly normal under homeostatic condition, b...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y

    更新日期:2020-04-06 00:00:00

  • Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury.

    abstract:BACKGROUND:Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and their role in inflammatory response after SCI remained unclear. This study aimed to investigate the ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Liu Z,Yao X,Jiang W,Li W,Zhu S,Liao C,Zou L,Ding R,Chen J

    更新日期:2020-03-20 00:00:00

  • DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke.

    abstract:BACKGROUND:Acute inflammation induced by reactive astrocytes after cerebral ischemia/reperfusion (I/R) injury is important for protecting the resultant lesion. Our previous study demonstrated that DJ-1 is abundantly expressed in reactive astrocytes after cerebral I/R injury. Here, we show that DJ-1 negatively regulates...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Peng L,Zhou Y,Jiang N,Wang T,Zhu J,Chen Y,Li L,Zhang J,Yu S,Zhao Y

    更新日期:2020-03-09 00:00:00

  • Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury.

    abstract:BACKGROUND:The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role in this process. In addition, cytokines and chemokines influence the phenotype of infiltrating imm...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Li L,Ni L,Heary RF,Elkabes S

    更新日期:2020-02-25 00:00:00

  • c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.

    abstract:BACKGROUND:CD8+ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system autoimmune disease pathology. We recently identified a novel population of highly cytotoxic c-Met-...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Benkhoucha M,Senoner I,Lalive PH

    更新日期:2020-02-19 00:00:00

  • Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis.

    abstract:BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severit...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Robichon K,Patel V,Connor B,La Flamme AC

    更新日期:2020-02-12 00:00:00

  • Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression.

    abstract::Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审


    authors: Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

    更新日期:2020-02-12 00:00:00

  • CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.

    abstract:BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG

    更新日期:2020-02-04 00:00:00

  • Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs.

    abstract:BACKGROUND:Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Grovola MR,Paleologos N,Wofford KL,Harris JP,Browne KD,Johnson V,Duda JE,Wolf JA,Cullen DK

    更新日期:2020-01-31 00:00:00

  • Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.

    abstract:BACKGROUND:Out of the myriad of complications associated with septic shock, septic-associated encephalopathy (SAE) carries a significant risk of morbidity and mortality. Blood-brain-barrier (BBB) impairment, which subsequently leads to increased vascular permeability, has been associated with neuronal injury in sepsis....

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Haileselassie B,Joshi AU,Minhas PS,Mukherjee R,Andreasson KI,Mochly-Rosen D

    更新日期:2020-01-27 00:00:00

  • High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.

    abstract:AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

    更新日期:2020-01-24 00:00:00

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