Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition.

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induc...

journal_title：Journal of neuroinflammation

authors： Li M,Li C,Yu H,Cai X,Shen X,Sun X,Wang J,Zhang Y,Wang C

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) makes a great contribution to host defense and inflammation. In many settings, lipopolysaccharide (LPS) induces iNOS expression through activation of the inhibitor of κB-α (IκB-α)-nuclear factor-κB (NF-κB) cascade, whereas interferon-γ (IFN-γ) acts through Janus kinase ...

journal_title：Journal of neuroinflammation

authors： Huang C,Lu X,Tong L,Wang J,Zhang W,Jiang B,Yang R

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which may be related to the pathophysiology of this disease. In addition to glutamate transporters, level...

journal_title：Journal of neuroinflammation

authors： Pampliega O,Domercq M,Soria FN,Villoslada P,Rodríguez-Antigüedad A,Matute C

更新日期：2011-06-03 00:00:00

abstract：BACKGROUND:A key feature of the inflammatory response after cerebral ischemia is the brain infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood: CCR2+Ly6Chi "inflammatory" monocytes involved in acute inflammation, and CX3CR1+Ly6Clo "patrolling" monocytes, which may play a role in repa...

journal_title：Journal of neuroinflammation

authors： Garcia-Bonilla L,Faraco G,Moore J,Murphy M,Racchumi G,Srinivasan J,Brea D,Iadecola C,Anrather J

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks colony-stimulating factor-1 (CSF-1) and thus has a deficiency in microglia and macrophages. Prior reports ...

journal_title：Journal of neuroinflammation

authors： Kondo Y,Lemere CA,Seabrook TJ

更新日期：2007-12-20 00:00:00

abstract：BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

journal_title：Journal of neuroinflammation

authors： Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their a...

journal_title：Journal of neuroinflammation

authors： Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G

更新日期：2019-02-12 00:00:00

abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

journal_title：Journal of neuroinflammation

authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:In brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the initial events triggered by inflammation or oxidative stress that provoke axonal damage is critical for the development of neuroprotective therapies. Energy...

journal_title：Journal of neuroinflammation

authors： Errea O,Moreno B,Gonzalez-Franquesa A,Garcia-Roves PM,Villoslada P

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing...

journal_title：Journal of neuroinflammation

authors： Shrestha S,Kim MJ,Eldridge M,Lehmann ML,Frankland M,Liow JS,Yu ZX,Cortes-Salva M,Telu S,Henter ID,Gallagher E,Lee JH,Fredericks JM,Poffenberger C,Tye G,Ruiz-Perdomo Y,Anaya FJ,Montero Santamaria JA,Gladding RL,Zoghb

更新日期：2020-05-02 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxi...

journal_title：Journal of neuroinflammation

authors： Yang EJ,Kim SH,Yang SC,Lee SM,Choi SM

更新日期：2011-06-20 00:00:00

abstract：BACKGROUND:Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (statin-Dex) on EAMG are still unk...

journal_title：Journal of neuroinflammation

authors： Li XL,Li H,Zhang M,Xu H,Yue LT,Zhang XX,Wang S,Wang CC,Li YB,Dou YC,Duan RS

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...

journal_title：Journal of neuroinflammation

authors： Mayado A,Torres E,Gutierrez-Lopez MD,Colado MI,O'Shea E

更新日期：2011-11-24 00:00:00

abstract：:Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do...

journal_title：Journal of neuroinflammation

authors： Hammad A,Westacott L,Zaben M

更新日期：2018-01-22 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

journal_title：Journal of neuroinflammation

authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...

journal_title：Journal of neuroinflammation

authors： Mezzapesa A,Orset C,Plawinski L,Doeuvre L,Martinez de Lizarrondo S,Chimienti G,Vivien D,Mansour A,Matà S,Pepe G,Anglés-Cano E

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Human marrow stromal cells (hMSCs) injected intrathecally can effectively increase the lifespan and protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis. However, how the transplanted cells exert a neuroprotective effect is still unclear. More recently, the anti-inflammation eff...

journal_title：Journal of neuroinflammation

authors： Zhou C,Zhang C,Zhao R,Chi S,Ge P,Zhang C

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of C/EBPδ durin...

journal_title：Journal of neuroinflammation

authors： Valls Serón M,Duitman J,Geldhoff M,Engelen-Lee J,Havik SR,Brouwer MC,van de Beek D,Spek CA

更新日期：2015-05-10 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...

journal_title：Journal of neuroinflammation

authors： Bahia El Idrissi N,Bosch S,Ramaglia V,Aronica E,Baas F,Troost D

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

journal_title：Journal of neuroinflammation

authors： Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for ...

journal_title：Journal of neuroinflammation

authors： Chen X,Wu S,Chen C,Xie B,Fang Z,Hu W,Chen J,Fu H,He H

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Buttmann M,Glaser K

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Neuroinflammation is considered a risk factor for impairments in neuronal function and cognition that arise with trauma, infection, and/or disease. IL-17A has been determined to be involved in neurodegenerative diseases such as multiple sclerosis. Recently, IL-17A has been shown to be upregulated in lipopoly...

journal_title：Journal of neuroinflammation

authors： Sun J,Zhang S,Zhang X,Zhang X,Dong H,Qian Y

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective treatment to inhibit the...

journal_title：Journal of neuroinflammation

authors： Jiang L,Pan CL,Wang CY,Liu BQ,Han Y,Hu L,Liu L,Yang Y,Qu JW,Liu WT

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adap...

journal_title：Journal of neuroinflammation

authors： Kurhade C,Zegenhagen L,Weber E,Nair S,Michaelsen-Preusse K,Spanier J,Gekara NO,Kröger A,Överby AK

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00