Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood-brain barrier.

abstract：BACKGROUND:Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer's disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD:In this study, we investigated Aβ-effects on heat s...

journal_title：Journal of neuroinflammation

authors： Lamoke F,Mazzone V,Persichini T,Maraschi A,Harris MB,Venema RC,Colasanti M,Gliozzi M,Muscoli C,Bartoli M,Mollace V

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

journal_title：Journal of neuroinflammation

authors： Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induction of depression-like behaviors in animal models. Several studies hav...

journal_title：Journal of neuroinflammation

authors： Brooks AK,Lawson MA,Smith RA,Janda TM,Kelley KW,McCusker RH

更新日期：2016-05-03 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke...

journal_title：Journal of neuroinflammation

authors： Gautier S,Ouk T,Tagzirt M,Lefebvre C,Laprais M,Pétrault O,Dupont A,Leys D,Bordet R

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:Pharmaceutical treatment with probable anti-inflammatory substances that attack cells in various ways including receptors, ion channels, or transporter systems may slow down the progression of inflammatory conditions. Astrocytes and microglia are the most prominent target cells for inflammation in the centra...

journal_title：Journal of neuroinflammation

authors： Hansson E,Björklund U,Skiöldebrand E,Rönnbäck L

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

journal_title：Journal of neuroinflammation

authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Human marrow stromal cells (hMSCs) injected intrathecally can effectively increase the lifespan and protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis. However, how the transplanted cells exert a neuroprotective effect is still unclear. More recently, the anti-inflammation eff...

journal_title：Journal of neuroinflammation

authors： Zhou C,Zhang C,Zhao R,Chi S,Ge P,Zhang C

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...

journal_title：Journal of neuroinflammation

authors： Li J,Fang L,Meyer P,Killer HE,Flammer J,Neutzner A

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and anxiety. While neuroinflammation in the hypothalamic paraventricu...

journal_title：Journal of neuroinflammation

authors： Althammer F,Ferreira-Neto HC,Rubaharan M,Roy RK,Patel AA,Murphy A,Cox DN,Stern JE

更新日期：2020-07-23 00:00:00

abstract：:The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome is a member of the NLR family of innate immune cell sensors. These are crucial regulators of cytokine secretions, which promote ischemic cell death and insulin resistance. This review summarizes rece...

journal_title：Journal of neuroinflammation

authors： Hong P,Gu RN,Li FX,Xiong XX,Liang WB,You ZJ,Zhang HF

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

journal_title：Journal of neuroinflammation

authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:CD8+ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system autoimmune disease pathology. We recently identified a novel population of highly cytotoxic c-Met-...

journal_title：Journal of neuroinflammation

authors： Benkhoucha M,Senoner I,Lalive PH

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (statin-Dex) on EAMG are still unk...

journal_title：Journal of neuroinflammation

authors： Li XL,Li H,Zhang M,Xu H,Yue LT,Zhang XX,Wang S,Wang CC,Li YB,Dou YC,Duan RS

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

journal_title：Journal of neuroinflammation

authors： Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing...

journal_title：Journal of neuroinflammation

authors： Shrestha S,Kim MJ,Eldridge M,Lehmann ML,Frankland M,Liow JS,Yu ZX,Cortes-Salva M,Telu S,Henter ID,Gallagher E,Lee JH,Fredericks JM,Poffenberger C,Tye G,Ruiz-Perdomo Y,Anaya FJ,Montero Santamaria JA,Gladding RL,Zoghb

更新日期：2020-05-02 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pathway in ...

journal_title：Journal of neuroinflammation

authors： Hopp S,Nolte MW,Stetter C,Kleinschnitz C,Sirén AL,Albert-Weissenberger C

更新日期：2017-02-20 00:00:00

abstract：:The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS). Quinolinic acid levels are elevated in experimental autoimmune encephalomyelitis rodents, the widely used animal model of MS. Our group has also found pat...

journal_title：Journal of neuroinflammation

authors： Sundaram G,Brew BJ,Jones SP,Adams S,Lim CK,Guillemin GJ

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:Cannabinoid-2 receptor (CB2R) plays an important role in the cascading inflammation following ischemic injury. The toll-like receptors 4 (TLR4)/matrix metalloproteinase 9 (MMP9) signal pathway is involved in blood-brain barrier dysfunction induced by ischemia stroke. The aim of this study is to investigate t...

journal_title：Journal of neuroinflammation

authors： Jing N,Fang B,Li Z,Tian A

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Microglia and astrocytes are likely to play a significant role in viral encephalitis pathophysiology as they are ideally positioned to respond to invading central nervous system (CNS) pathogens by producing k...

journal_title：Journal of neuroinflammation

authors： Furr SR,Chauhan VS,Moerdyk-Schauwecker MJ,Marriott I

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (...

journal_title：Journal of neuroinflammation

authors： Byrnes KR,Loane DJ,Stoica BA,Zhang J,Faden AI

更新日期：2012-02-28 00:00:00

abstract：:Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain disorder characterized by recurrent seizures originating from the hippocampus. The pathogenic mechanisms underlying mTLE remain largely unknown. Recent clinical and experimental evidence supports a role of various inflammatory media...

journal_title：Journal of neuroinflammation

authors： Kan AA,de Jager W,de Wit M,Heijnen C,van Zuiden M,Ferrier C,van Rijen P,Gosselaar P,Hessel E,van Nieuwenhuizen O,de Graan PN

更新日期：2012-08-30 00:00:00

abstract：BACKGROUND:Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are expressed by microglia and infiltrating macrophages following ischemic stroke. Whereas IL-1beta is primarily neurotoxic in ischemic stroke, TNF-alpha may have neurotoxic and/or neuroprotective effects. We investigated whether IL-1be...

journal_title：Journal of neuroinflammation

authors： Clausen BH,Lambertsen KL,Babcock AA,Holm TH,Dagnaes-Hansen F,Finsen B

更新日期：2008-10-23 00:00:00

abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

journal_title：Journal of neuroinflammation

authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

更新日期：2014-05-06 00:00:00

abstract：OBJECTIVE:Converging lines of evidence point to the existence of immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key neurodevelopmental processes. Previous studies have shown higher cytokine levels in patients with autism compared with matched controls or subjects with other de...

journal_title：Journal of neuroinflammation

authors： Napolioni V,Ober-Reynolds B,Szelinger S,Corneveaux JJ,Pawlowski T,Ober-Reynolds S,Kirwan J,Persico AM,Melmed RD,Craig DW,Smith CJ,Huentelman MJ

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

journal_title：Journal of neuroinflammation

authors： Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

更新日期：2016-06-18 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

journal_title：Journal of neuroinflammation

authors： Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

更新日期：2021-01-06 00:00:00