The link between chronic pain and Alzheimer's disease.

abstract：:Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

journal_title：Journal of neuroinflammation

authors： Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory reaction in response to bacterial brain invasion. Metformin-a biguanide...

journal_title：Journal of neuroinflammation

authors： Muri L,Le ND,Zemp J,Grandgirard D,Leib SL

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...

journal_title：Journal of neuroinflammation

authors： Shi X,Chen Y,Nadeem L,Xu G

更新日期：2013-06-04 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:In meningitis, the cerebrospinal fluid contains high levels of innate immune molecules (e.g. complement) which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes (neutrophils, monocytes). However, epithelial cells of either the ependymal layer, one of the establi...

journal_title：Journal of neuroinflammation

authors： Canova C,Neal JW,Gasque P

更新日期：2006-09-02 00:00:00

abstract：:Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do...

journal_title：Journal of neuroinflammation

authors： Hammad A,Westacott L,Zaben M

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...

journal_title：Journal of neuroinflammation

authors： Yshii LM,Denadai-Souza A,Vasconcelos AR,Avellar MC,Scavone C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was to gain more insight into the frequency, distribution and cellular architecture...

journal_title：Journal of neuroinflammation

authors： van Horssen J,Singh S,van der Pol S,Kipp M,Lim JL,Peferoen L,Gerritsen W,Kooi EJ,Witte ME,Geurts JJ,de Vries HE,Peferoen-Baert R,van den Elsen PJ,van der Valk P,Amor S

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturate...

journal_title：Journal of neuroinflammation

authors： Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

更新日期：2017-09-12 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating pathology remains poorly characterized. OBJECTIVE:The objective of this study is to investigate whether...

journal_title：Journal of neuroinflammation

authors： Berg CT,Khorooshi R,Asgari N,Owens T

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...

journal_title：Journal of neuroinflammation

authors： Huang CY,Chen YL,Li AH,Lu JC,Wang HL

更新日期：2014-01-10 00:00:00

abstract：BACKGROUND:Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response and demonstrated that pharmacol...

journal_title：Journal of neuroinflammation

authors： Tang Y,Soroush F,Sun S,Liverani E,Langston JC,Yang Q,Kilpatrick LE,Kiani MF

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

journal_title：Journal of neuroinflammation

authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Andrographolide is the major bioactive compound isolated from Andrographis paniculata, a native South Asian herb used medicinally for its anti-inflammatory properties. In this study, we aimed to assess andrographolide's potential utility as an anti-neuroinflammatory therapeutic. METHODS:The effects of andro...

journal_title：Journal of neuroinflammation

authors： Wong SY,Tan MG,Banks WA,Wong WS,Wong PT,Lai MK

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous mediator of analgesia and...

journal_title：Journal of neuroinflammation

authors： Wang S,Zhang H,Geng B,Xie Q,Li W,Deng Y,Shi W,Pan Y,Kang X,Wang J

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experi...

journal_title：Journal of neuroinflammation

authors： Contarini G,Franceschini D,Facci L,Barbierato M,Giusti P,Zusso M

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

journal_title：Journal of neuroinflammation

authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible factor which may contribute is interferon-γ (IFNγ). IFNγ h...

journal_title：Journal of neuroinflammation

authors： Lyons A,Murphy KJ,Clarke R,Lynch MA

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

journal_title：Journal of neuroinflammation

authors： Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimmune encephalomyelitis (EAE), ...

journal_title：Journal of neuroinflammation

authors： Serguera C,Stimmer L,Fovet CM,Horellou P,Contreras V,Tchitchek N,Massonneau J,Leroy C,Perrin A,Flament J,Hantraye P,Demilly J,Marignier R,Chrétien P,Hart B,Boutonnat J,Adam C,Le-Grand R,Deiva K

更新日期：2019-11-30 00:00:00

abstract：BACKGROUND:The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in P...

journal_title：Journal of neuroinflammation

authors： Hou L,Qu X,Qiu X,Huang R,Zhao X,Wang Q

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

journal_title：Journal of neuroinflammation

authors： Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

journal_title：Journal of neuroinflammation

authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...

journal_title：Journal of neuroinflammation

authors： Mayado A,Torres E,Gutierrez-Lopez MD,Colado MI,O'Shea E

更新日期：2011-11-24 00:00:00

abstract：:BACKGROUND: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability t...

journal_title：Journal of neuroinflammation

authors： Hosokawa M,Klegeris A,McGeer PL

更新日期：2004-08-24 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS can start focally at a single...

journal_title：Journal of neuroinflammation

authors： Schram S,Loeb JA,Song F

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing...

journal_title：Journal of neuroinflammation

authors： Shrestha S,Kim MJ,Eldridge M,Lehmann ML,Frankland M,Liow JS,Yu ZX,Cortes-Salva M,Telu S,Henter ID,Gallagher E,Lee JH,Fredericks JM,Poffenberger C,Tye G,Ruiz-Perdomo Y,Anaya FJ,Montero Santamaria JA,Gladding RL,Zoghb

更新日期：2020-05-02 00:00:00