Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of neuroinflammation

authors： Wang YW,Zhou Q,Zhang X,Qian QQ,Xu JW,Ni PF,Qian YN

更新日期：2020-11-24 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

journal_title：Journal of neuroinflammation

authors： Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental i...

journal_title：Journal of neuroinflammation

authors： Moidunny S,Matos M,Wesseling E,Banerjee S,Volsky DJ,Cunha RA,Agostinho P,Boddeke HW,Roy S

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

journal_title：Journal of neuroinflammation

authors： Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

journal_title：Journal of neuroinflammation

authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could make a significant contribution to Aβ burden in AD. Moreover, act...

journal_title：Journal of neuroinflammation

authors： Zhao J,O'Connor T,Vassar R

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells around the plaques a...

journal_title：Journal of neuroinflammation

authors： Malm T,Mariani M,Donovan LJ,Neilson L,Landreth GE

更新日期：2015-01-16 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxi...

journal_title：Journal of neuroinflammation

authors： Yang EJ,Kim SH,Yang SC,Lee SM,Choi SM

更新日期：2011-06-20 00:00:00

abstract：:Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary infla...

journal_title：Journal of neuroinflammation

authors： Wang PF,Xiong XY,Chen J,Wang YC,Duan W,Yang QW

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

journal_title：Journal of neuroinflammation

authors： Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, IL-1β, and N-methyl D-aspartate receptor subunit 2B (NR2B) genes in cochlea and inferior colliculus (...

journal_title：Journal of neuroinflammation

authors： Hwang JH,Chen JC,Yang SY,Wang MF,Chan YC

更新日期：2011-04-09 00:00:00

abstract：BACKGROUND:Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospin...

journal_title：Journal of neuroinflammation

authors： Wuhrer M,Selman MH,McDonnell LA,Kümpfel T,Derfuss T,Khademi M,Olsson T,Hohlfeld R,Meinl E,Krumbholz M

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for ...

journal_title：Journal of neuroinflammation

authors： Chen X,Wu S,Chen C,Xie B,Fang Z,Hu W,Chen J,Fu H,He H

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) induces neuronal dysfunction through host cellular factors and viral proteins including viral protein R (Vpr) released from infected macrophages/microglia. Vpr is important for infection of terminally differentiated cells such as macrophages. The objective of this ...

journal_title：Journal of neuroinflammation

authors： Guha D,Nagilla P,Redinger C,Srinivasan A,Schatten GP,Ayyavoo V

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is characterized by the pathological trafficking of leukocytes into the central nervous system (CNS). Using the murine MS model, experimental autoimmune encephalomyelitis (EAE), we previously demonstrated that antagonism of the chemokine receptor CXCR7 blocks endothelial cell sequestr...

journal_title：Journal of neuroinflammation

authors： Cruz-Orengo L,Chen YJ,Kim JH,Dorsey D,Song SK,Klein RS

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degen...

journal_title：Journal of neuroinflammation

authors： Gao J,Cui JZ,To E,Cao S,Matsubara JA

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who ha...

journal_title：Journal of neuroinflammation

authors： Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SH

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:Osteopontin (OPN, SPP1) is upregulated in response to acute brain injury, and based on its immunoreactivity, two distinct forms have been identified: intracellular OPN within brain macrophages and small granular OPN, identified as OPN-coated degenerated neurites. This study investigates the spatiotemporal re...

journal_title：Journal of neuroinflammation

authors： Riew TR,Kim S,Jin X,Kim HL,Lee JH,Lee MY

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroinflammation after ischemic stroke; however, its effect on modulating microglial polarization is larg...

journal_title：Journal of neuroinflammation

authors： Song D,Zhang X,Chen J,Liu X,Xue J,Zhang L,Lan X

更新日期：2019-12-06 00:00:00

abstract：BACKGROUND:We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that balance between dynor...

journal_title：Journal of neuroinflammation

authors： Dang DK,Shin EJ,Kim DJ,Tran HQ,Jeong JH,Jang CG,Nah SY,Jeong JH,Byun JK,Ko SK,Bing G,Hong JS,Kim HC

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke...

journal_title：Journal of neuroinflammation

authors： Gautier S,Ouk T,Tagzirt M,Lefebvre C,Laprais M,Pétrault O,Dupont A,Leys D,Bordet R

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomography (PET) radiotracer, (4S)-4...

journal_title：Journal of neuroinflammation

authors： Hoehne A,James ML,Alam IS,Ronald JA,Schneider B,D'Souza A,Witney TH,Andrews LE,Cropper HC,Behera D,Gowrishankar G,Ding Z,Wyss-Coray T,Chin FT,Biswal S,Gambhir SS

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

journal_title：Journal of neuroinflammation

authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

更新日期：2007-02-26 00:00:00

abstract：BACKGROUND:Neuroinflammation following acute brain trauma is considered to play a prominent role in both the pathological and reconstructive response of the brain to injury. Here we characterize and contrast both an acute and delayed phase of inflammation following experimental penetrating ballistic brain injury (PBBI)...

journal_title：Journal of neuroinflammation

authors： Williams AJ,Wei HH,Dave JR,Tortella FC

更新日期：2007-07-02 00:00:00

abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

journal_title：Journal of neuroinflammation

authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (statin-Dex) on EAMG are still unk...

journal_title：Journal of neuroinflammation

authors： Li XL,Li H,Zhang M,Xu H,Yue LT,Zhang XX,Wang S,Wang CC,Li YB,Dou YC,Duan RS

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (...

journal_title：Journal of neuroinflammation

authors： Byrnes KR,Loane DJ,Stoica BA,Zhang J,Faden AI

更新日期：2012-02-28 00:00:00