Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization.

abstract：BACKGROUND:Chorioamnionitis is associated with an increased risk of brain injury in preterm neonates. Inflammatory changes in brain could underlie this injury. Here, we evaluated whether neuroinflammation is induced by chorioamnionitis in a clinically relevant model. METHODS:Rhesus macaque fetuses were exposed to eith...

journal_title：Journal of neuroinflammation

authors： Schmidt AF,Kannan PS,Chougnet CA,Danzer SC,Miller LA,Jobe AH,Kallapur SG

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contributions of each of the ...

journal_title：Journal of neuroinflammation

authors： Orsini F,Chrysanthou E,Dudler T,Cummings WJ,Takahashi M,Fujita T,Demopulos G,De Simoni MG,Schwaeble W

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but are not a quickly measured serum inflammatory or neuronal biomarkers to rapidly a...

journal_title：Journal of neuroinflammation

authors： Borjini N,Sivilia S,Giuliani A,Fernandez M,Giardino L,Facchinetti F,Calzà L

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. with host defense mechanisms are poorly understood. This study addressed Ureaplasma-driven...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Haarmann A,Fehrholz M,Claus H,Speer CP,Glaser K

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Exposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer's disease (AD)-like pathological changes. However, it is largely unknown whether BaP exposure participates in the disease progression of AD. OBJECTIVES:To investigate the effect of BaP exposure on AD progression an...

journal_title：Journal of neuroinflammation

authors： Liu D,Zhao Y,Qi Y,Gao Y,Tu D,Wang Y,Gao HM,Zhou H

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS). The aim of the present study was to apprai...

journal_title：Journal of neuroinflammation

authors： Teixeira NB,Picolo G,Giardini AC,Boumezbeur F,Pottier G,Kuhnast B,Servent D,Benoit E

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

journal_title：Journal of neuroinflammation

authors： Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Excessive inflammation might activate and injure the blood-brain barrier (BBB), a common feature of many central nervous system (CNS) disorders. We previously developed an in vitro BBB injury model in which the organophosphate paraoxon (PX) affects the BBB endothelium by attenuating junctional protein expres...

journal_title：Journal of neuroinflammation

authors： Israelov H,Ravid O,Atrakchi D,Rand D,Elhaik S,Bresler Y,Twitto-Greenberg R,Omesi L,Liraz-Zaltsman S,Gosselet F,Schnaider Beeri M,Cooper I

更新日期：2020-09-09 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：:Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric...

journal_title：Journal of neuroinflammation

authors： Najjar S,Pearlman DM,Alper K,Najjar A,Devinsky O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macrophages infiltrate the CNS dur...

journal_title：Journal of neuroinflammation

authors： DePaula-Silva AB,Gorbea C,Doty DJ,Libbey JE,Sanchez JMS,Hanak TJ,Cazalla D,Fujinami RS

更新日期：2019-07-20 00:00:00

abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...

journal_title：Journal of neuroinflammation

authors： Dong T,Zhi L,Bhayana B,Wu MX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cyclohexene-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanami...

journal_title：Journal of neuroinflammation

authors： Ham HJ,Lee YS,Yun J,Son DJ,Lee HP,Han SB,Hong JT

更新日期：2020-11-22 00:00:00

abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

journal_title：Journal of neuroinflammation

authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through its NK1 receptor. Incr...

journal_title：Journal of neuroinflammation

authors： Martinez AN,Ramesh G,Jacobs MB,Philipp MT

更新日期：2015-12-30 00:00:00

abstract：AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

journal_title：Journal of neuroinflammation

authors： Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Oxidative stress plays an important and causal role in the mechanisms by which ischemia/reperfusion (I/R) injury increases brain damage after stroke. Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for limiting damage in the brain after stroke. Myeloperoxidase (MPO) is a hi...

journal_title：Journal of neuroinflammation

authors： Yu G,Liang Y,Huang Z,Jones DW,Pritchard KA Jr,Zhang H

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely involves chronic imm...

journal_title：Journal of neuroinflammation

authors： Kim S,Hahn YK,Podhaizer EM,McLane VD,Zou S,Hauser KF,Knapp PE

更新日期：2018-10-10 00:00:00

abstract：BACKGROUND:Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental i...

journal_title：Journal of neuroinflammation

authors： Moidunny S,Matos M,Wesseling E,Banerjee S,Volsky DJ,Cunha RA,Agostinho P,Boddeke HW,Roy S

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model. METHODS:In both control and endotoxinemic (5 mg/kg li...

journal_title：Journal of neuroinflammation

authors： Mihaylova S,Killian A,Mayer K,Pullamsetti SS,Schermuly R,Rosengarten B

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:Recent studies described a critical role for microglia in Parkinson's disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra. Understanding the phenotype switch of microgl...

journal_title：Journal of neuroinflammation

authors： Lu J,Dou F,Yu Z

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer's disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharmacological antagonism ...

journal_title：Journal of neuroinflammation

authors： Ryu JK,Cho T,Choi HB,Jantaratnotai N,McLarnon JG

更新日期：2015-08-09 00:00:00

abstract：:Although neuroinflammation has been studied extensively in animal models of cerebral ischemia, their contrasting functions are still not completely understood. A major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine CX3CL1 (fractalkine) and its receptor, CX3CR...

journal_title：Journal of neuroinflammation

authors： Briones TL,Woods J,Wadowska M

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate immune sensing. Its activation leads to the maturation of caspase-1 and regulates the cleavage of interleukin (IL)-1β and IL-18. Various studies have shown t...

journal_title：Journal of neuroinflammation

authors： Zhang ZT,Du XM,Ma XJ,Zong Y,Chen JK,Yu CL,Liu YG,Chen YC,Zhao LJ,Lu GC

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Acute inflammation induced by reactive astrocytes after cerebral ischemia/reperfusion (I/R) injury is important for protecting the resultant lesion. Our previous study demonstrated that DJ-1 is abundantly expressed in reactive astrocytes after cerebral I/R injury. Here, we show that DJ-1 negatively regulates...

journal_title：Journal of neuroinflammation

authors： Peng L,Zhou Y,Jiang N,Wang T,Zhu J,Chen Y,Li L,Zhang J,Yu S,Zhao Y

更新日期：2020-03-09 00:00:00

abstract：:Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation. Several studies suggest that harmful immune/inflammatory responses may be the most impactful consequence of aberrant CN activity in glial cell...

journal_title：Journal of neuroinflammation

authors： Furman JL,Norris CM

更新日期：2014-09-10 00:00:00