The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease.

Abstract:

BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors into the brain. To our knowledge, this is the first study to examine microbiome alteration prior to the induction of a PD murine model. METHODS:We presently assessed whether pre-treatment with the probiotic, VSL #3, or the inflammatory inducer, dextran sodium sulphate (DSS), would influence the PD-like pathology provoked by a dual hit toxin model using lipopolysaccharide (LPS) and paraquat exposure. RESULTS:While VSL #3 has been reported to have anti-inflammatory effects, DSS is often used as a model of colitis because of the gut inflammation and the breach of the intestinal barrier that it induces. We found that VSL#3 did not have any significant effects (beyond a blunting of LPS paraquat-induced weight loss). However, the DSS treatment caused marked changes in the gut microbiome and was also associated with augmented behavioral and inflammatory outcomes. In fact, DSS markedly increased taxa belonging to the Bacteroidaceae and Porphyromonadaceae families but reduced those from Rikencellaceae and S24-7, as well as provoking colonic pro-inflammatory cytokine expression, consistent with an inflamed gut. The DSS also increased the impact of LPS plus paraquat upon microglial morphology, along with circulating lipocalin-2 (neutrophil marker) and IL-6. Yet, neither DSS nor VSL#3 influenced the loss of substantia nigra dopamine neurons or the astrocytic and cytoskeleton remodeling protein changes that were provoked by the LPS followed by paraquat treatment. CONCLUSIONS:These data suggest that disruption of the intestinal integrity and the associated microbiome can interact with systemic inflammatory events to promote widespread brain-gut changes that could be relevant for PD and at the very least, suggestive of novel neuro-immune communication.

journal_name

J Neuroinflammation

authors

Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

doi

10.1186/s12974-020-02062-2

subject

Has Abstract

pub_date

2021-01-09 00:00:00

pages

20

issue

1

issn

1742-2094

pii

10.1186/s12974-020-02062-2

journal_volume

18

pub_type

杂志文章
  • High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects.

    abstract:BACKGROUND:Transforming growth factor β (TGF-β) is a cytokine having multiple functions in the central nervous system such as promoting repair mechanisms in degenerative diseases and stroke. To date, however, its neuroprotective effects in non-disease conditions have not been studied METHODS:With the aim of exploring ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-42

    authors: Piras F,Salani F,Bossù P,Caltagirone C,Spalletta G

    更新日期:2012-02-28 00:00:00

  • Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells.

    abstract:BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-8-8

    authors: Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

    更新日期:2011-01-24 00:00:00

  • Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.

    abstract:BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0412-7

    authors: Yshii LM,Denadai-Souza A,Vasconcelos AR,Avellar MC,Scavone C

    更新日期:2015-10-26 00:00:00

  • 5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.

    abstract:BACKGROUND:The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the present study, we focused on the ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-34

    authors: Lee JH,Kim H,Woo JH,Joe EH,Jou I

    更新日期:2012-02-18 00:00:00

  • Increased frequency of IL-6-producing non-classical monocytes in neuromyelitis optica spectrum disorder.

    abstract:BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-017-0961-z

    authors: Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

    更新日期:2017-09-25 00:00:00

  • The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism.

    abstract:BACKGROUND:Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases. Autoimmunity may have a role in the pathogenesis of autism in ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-8-180

    authors: Mostafa GA,Al-Ayadhi LY

    更新日期:2011-12-21 00:00:00

  • Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro.

    abstract:BACKGROUND:Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inhibitor approved in th...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-019-1565-6

    authors: Gavegnano C,Haile WB,Hurwitz S,Tao S,Jiang Y,Schinazi RF,Tyor WR

    更新日期:2019-09-27 00:00:00

  • Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats.

    abstract:BACKGROUND:Spinal cord ischemia-reperfusion (I/R) involves two-phase injury, including an initial acute ischemic insult and subsequent inflammatory reperfusion injury, resulting in blood-spinal cord barrier (BSCB) dysfunction involving the TLR₄ pathway. However, the correlation between TLR₄/MyD₈₈-dependent and TLR₄/TRI...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-11-62

    authors: Li XQ,Lv HW,Tan WF,Fang B,Wang H,Ma H

    更新日期:2014-03-28 00:00:00

  • Correction to: Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Journal of neuroinflammation

    pub_type: 已发布勘误

    doi:10.1186/s12974-020-01990-3

    authors: Wang YW,Zhou Q,Zhang X,Qian QQ,Xu JW,Ni PF,Qian YN

    更新日期:2020-11-24 00:00:00

  • Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome.

    abstract:BACKGROUND:The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate immune sensing. Its activation leads to the maturation of caspase-1 and regulates the cleavage of interleukin (IL)-1β and IL-18. Various studies have shown t...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0539-1

    authors: Zhang ZT,Du XM,Ma XJ,Zong Y,Chen JK,Yu CL,Liu YG,Chen YC,Zhao LJ,Lu GC

    更新日期:2016-04-05 00:00:00

  • Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1.

    abstract:BACKGROUND:Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contributions of each of the ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0684-6

    authors: Orsini F,Chrysanthou E,Dudler T,Cummings WJ,Takahashi M,Fujita T,Demopulos G,De Simoni MG,Schwaeble W

    更新日期:2016-08-30 00:00:00

  • A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain.

    abstract:BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1116-6

    authors: Montague K,Simeoli R,Valente J,Malcangio M

    更新日期:2018-04-06 00:00:00

  • Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood-brain barrier.

    abstract:BACKGROUND AND PURPOSE:Inflammatory reaction plays a crucial role in cerebral ischemia reperfusion (IR) injury. It has been shown that activated microglia long-term existed in cerebral ischemia and induced second injury. Therefore, we hypothesize that prepared phosphatidylserine (PS)-modified microbubbles (PS-MBs) comb...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1368-1

    authors: Zhao R,Jiang J,Li H,Chen M,Liu R,Sun S,Ma,Liang X,Wang S

    更新日期:2018-11-30 00:00:00

  • Ecto-5'-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice.

    abstract:BACKGROUND:Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternativ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1183-8

    authors: Xu S,Zhu W,Shao M,Zhang F,Guo J,Xu H,Jiang J,Ma X,Xia X,Zhi X,Zhou P,Lu F

    更新日期:2018-05-22 00:00:00

  • Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

    abstract:BACKGROUND:There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS:We studied the HLA-B & C a...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-3-33

    authors: Lehmann DJ,Barnardo MC,Fuggle S,Quiroga I,Sutherland A,Warden DR,Barnetson L,Horton R,Beck S,Smith AD

    更新日期:2006-12-18 00:00:00

  • Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

    abstract:BACKGROUND:Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs) mitigate DAergic neurotoxicity in rodent models of PD. ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-7-83

    authors: L'Episcopo F,Tirolo C,Caniglia S,Testa N,Serra PA,Impagnatiello F,Morale MC,Marchetti B

    更新日期:2010-11-23 00:00:00

  • Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

    abstract:BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged inflammatory response via its recognition by micr...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-019-1473-9

    authors: El Hajj H,Savage JC,Bisht K,Parent M,Vallières L,Rivest S,Tremblay MÈ

    更新日期:2019-04-16 00:00:00

  • Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).

    abstract:BACKGROUND:Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known to decrease neuronal cell death and inflammatory response after ischemia, SCI, ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0252-5

    authors: Tsumuraya T,Ohtaki H,Song D,Sato A,Watanabe J,Hiraizumi Y,Nakamachi T,Xu Z,Dohi K,Hashimoto H,Atsumi T,Shioda S

    更新日期:2015-02-22 00:00:00

  • Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide.

    abstract:BACKGROUND:Brain microvascular pericytes are important constituents of the neurovascular unit. These cells are physically the closest cells to the microvascular endothelial cells in brain capillaries. They significantly contribute to the induction and maintenance of the barrier functions of the blood-brain barrier. How...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-8-139

    authors: Kovac A,Erickson MA,Banks WA

    更新日期:2011-10-13 00:00:00

  • Association of social and cognitive impairment and biomarkers in autism spectrum disorders.

    abstract:OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-11-4

    authors: Alabdali A,Al-Ayadhi L,El-Ansary A

    更新日期:2014-01-08 00:00:00

  • Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.

    abstract:BACKGROUND:In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was to gain more insight into the frequency, distribution and cellular architecture...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-9-156

    authors: van Horssen J,Singh S,van der Pol S,Kipp M,Lim JL,Peferoen L,Gerritsen W,Kooi EJ,Witte ME,Geurts JJ,de Vries HE,Peferoen-Baert R,van den Elsen PJ,van der Valk P,Amor S

    更新日期:2012-07-02 00:00:00

  • Compound 49b protects against blast-induced retinal injury.

    abstract:AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/1742-2094-10-96

    authors: Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

    更新日期:2013-07-30 00:00:00

  • PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study.

    abstract:BACKGROUND:Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-01804-6

    authors: Shrestha S,Kim MJ,Eldridge M,Lehmann ML,Frankland M,Liow JS,Yu ZX,Cortes-Salva M,Telu S,Henter ID,Gallagher E,Lee JH,Fredericks JM,Poffenberger C,Tye G,Ruiz-Perdomo Y,Anaya FJ,Montero Santamaria JA,Gladding RL,Zoghb

    更新日期:2020-05-02 00:00:00

  • The disruption of mitochondrial axonal transport is an early event in neuroinflammation.

    abstract:BACKGROUND:In brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the initial events triggered by inflammation or oxidative stress that provoke axonal damage is critical for the development of neuroprotective therapies. Energy...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-015-0375-8

    authors: Errea O,Moreno B,Gonzalez-Franquesa A,Garcia-Roves PM,Villoslada P

    更新日期:2015-08-28 00:00:00

  • CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation.

    abstract:BACKGROUND:The small population of glioma stem-like cells (GSCs) contributes to tumor initiation, malignancy, and recurrence in glioblastoma. However, the maintenance of GSC properties in the tumor microenvironment remains unclear. In glioma, non-neoplastic cells create an inflammatory environment and subsequently medi...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-019-1535-z

    authors: Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ,Ko CY

    更新日期:2019-07-12 00:00:00

  • Necrotizing enterocolitis is associated with acute brain responses in preterm pigs.

    abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-018-1201-x

    authors: Sun J,Pan X,Christiansen LI,Yuan XL,Skovgaard K,Chatterton DEW,Kaalund SS,Gao F,Sangild PT,Pankratova S

    更新日期:2018-06-09 00:00:00

  • Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress.

    abstract:BACKGROUND:Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) gene delivery...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0499-5

    authors: Hines-Beard J,Bond WS,Backstrom JR,Rex TS

    更新日期:2016-02-15 00:00:00

  • Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model.

    abstract:BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-016-0632-5

    authors: Sommer A,Fadler T,Dorfmeister E,Hoffmann AC,Xiang W,Winner B,Prots I

    更新日期:2016-06-30 00:00:00

  • Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner.

    abstract:BACKGROUND:Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity i...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-017-0889-3

    authors: Benusa SD,George NM,Sword BA,DeVries GH,Dupree JL

    更新日期:2017-06-08 00:00:00

  • Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring.

    abstract:BACKGROUND:Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of b...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章

    doi:10.1186/s12974-020-01798-1

    authors: Wijenayake S,Rahman MF,Lum CMW,De Vega WC,Sasaki A,McGowan PO

    更新日期:2020-04-15 00:00:00