Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease mice.

abstract：BACKGROUND:Microglia/macrophages (MG/MΦ) are found in the subretinal space in both mice and humans. Our goal was to study the spatial and temporal distribution, the phenotype, and gene expression of subretinal MG/MΦ in mice with normal retinas and compare them to mice with known retinal pathology. METHODS:We studied C...

journal_title：Journal of neuroinflammation

authors： Aredo B,Zhang K,Chen X,Wang CX,Li T,Ufret-Vincenty RL

更新日期：2015-01-15 00:00:00

abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

journal_title：Journal of neuroinflammation

authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (AS...

journal_title：Journal of neuroinflammation

authors： Jyonouchi H,Geng L,Davidow AL

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response and demonstrated that pharmacol...

journal_title：Journal of neuroinflammation

authors： Tang Y,Soroush F,Sun S,Liverani E,Langston JC,Yang Q,Kilpatrick LE,Kiani MF

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...

journal_title：Journal of neuroinflammation

authors： Watkins LM,Neal JW,Loveless S,Michailidou I,Ramaglia V,Rees MI,Reynolds R,Robertson NP,Morgan BP,Howell OW

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) gene delivery...

journal_title：Journal of neuroinflammation

authors： Hines-Beard J,Bond WS,Backstrom JR,Rex TS

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

journal_title：Journal of neuroinflammation

authors： Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

journal_title：Journal of neuroinflammation

authors： Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospin...

journal_title：Journal of neuroinflammation

authors： Wuhrer M,Selman MH,McDonnell LA,Kümpfel T,Derfuss T,Khademi M,Olsson T,Hohlfeld R,Meinl E,Krumbholz M

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-gal...

journal_title：Journal of neuroinflammation

authors： Ullah R,Jo MH,Riaz M,Alam SI,Saeed K,Ali W,Rehman IU,Ikram M,Kim MO

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their a...

journal_title：Journal of neuroinflammation

authors： Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofilament light chain (NFL) in cerebrospinal fluid (CSF) and serum and the relationship between NFL and...

journal_title：Journal of neuroinflammation

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:FTY720 (fingolimod, Gilenya) is a daily oral therapy for multiple sclerosis that readily accesses the central nervous system (CNS). FTY720 is a structural analog to the sphingolipid sphingosine-1-phosphate (S1P) and is a cognate ligand for the S1P G-protein coupled receptors (S1PR). Studies in experimental a...

journal_title：Journal of neuroinflammation

authors： Wu C,Leong SY,Moore CS,Cui QL,Gris P,Bernier LP,Johnson TA,Séguéla P,Kennedy TE,Bar-Or A,Antel JP

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domai...

journal_title：Journal of neuroinflammation

authors： Zhu X,Li X,Zhu M,Xu K,Yang L,Han B,Huang R,Zhang A,Yao H

更新日期：2018-08-04 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others n...

journal_title：Journal of neuroinflammation

authors： Virgili N,Espinosa-Parrilla JF,Mancera P,Pastén-Zamorano A,Gimeno-Bayon J,Rodríguez MJ,Mahy N,Pugliese M

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophages ...

journal_title：Journal of neuroinflammation

authors： Chu T,Zhang YP,Tian Z,Ye C,Zhu M,Shields LBE,Kong M,Barnes GN,Shields CB,Cai J

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is...

journal_title：Journal of neuroinflammation

authors： Yamamoto S,Yamashina K,Ishikawa M,Gotoh M,Yagishita S,Iwasa K,Maruyama K,Murakami-Murofushi K,Yoshikawa K

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Spinal cord ischemia-reperfusion (I/R) involves two-phase injury, including an initial acute ischemic insult and subsequent inflammatory reperfusion injury, resulting in blood-spinal cord barrier (BSCB) dysfunction involving the TLR₄ pathway. However, the correlation between TLR₄/MyD₈₈-dependent and TLR₄/TRI...

journal_title：Journal of neuroinflammation

authors： Li XQ,Lv HW,Tan WF,Fang B,Wang H,Ma H

更新日期：2014-03-28 00:00:00

abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

journal_title：Journal of neuroinflammation

authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has been shown that during chronic inflammation, neuronal integrity i...

journal_title：Journal of neuroinflammation

authors： Benusa SD,George NM,Sword BA,DeVries GH,Dupree JL

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

journal_title：Journal of neuroinflammation

authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

journal_title：Journal of neuroinflammation

authors： Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

journal_title：Journal of neuroinflammation

authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

journal_title：Journal of neuroinflammation

authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

更新日期：2007-02-26 00:00:00

abstract：BACKGROUND:Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is an important regulator of g...

journal_title：Journal of neuroinflammation

authors： Straccia M,Gresa-Arribas N,Dentesano G,Ejarque-Ortiz A,Tusell JM,Serratosa J,Solà C,Saura J

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS:We studied the HLA-B & C a...

journal_title：Journal of neuroinflammation

authors： Lehmann DJ,Barnardo MC,Fuggle S,Quiroga I,Sutherland A,Warden DR,Barnetson L,Horton R,Beck S,Smith AD

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Human marrow stromal cells (hMSCs) injected intrathecally can effectively increase the lifespan and protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis. However, how the transplanted cells exert a neuroprotective effect is still unclear. More recently, the anti-inflammation eff...

journal_title：Journal of neuroinflammation

authors： Zhou C,Zhang C,Zhao R,Chi S,Ge P,Zhang C

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cel...

journal_title：Journal of neuroinflammation

authors： Torres L,Noel RJ Jr

更新日期：2014-03-22 00:00:00

abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Buttmann M,Glaser K

更新日期：2018-05-23 00:00:00