NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflammation, in vivo. The second generation PET radioligand [18F]DPA714 binds with hi...

journal_title：Journal of neuroinflammation

authors： Hagens MHJ,Golla SV,Wijburg MT,Yaqub M,Heijtel D,Steenwijk MD,Schober P,Brevé JJP,Schuit RC,Reekie TA,Kassiou M,van Dam AM,Windhorst AD,Killestein J,Barkhof F,van Berckel BNM,Lammertsma AA

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer's disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD:In this study, we investigated Aβ-effects on heat s...

journal_title：Journal of neuroinflammation

authors： Lamoke F,Mazzone V,Persichini T,Maraschi A,Harris MB,Venema RC,Colasanti M,Gliozzi M,Muscoli C,Bartoli M,Mollace V

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experi...

journal_title：Journal of neuroinflammation

authors： Contarini G,Franceschini D,Facci L,Barbierato M,Giusti P,Zusso M

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

journal_title：Journal of neuroinflammation

authors： Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...

journal_title：Journal of neuroinflammation

authors： Hinojosa AE,Caso JR,García-Bueno B,Leza JC,Madrigal JL

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:More than 50% of patients undergoing lifelong suppressive antiviral treatment for HIV-1 infection develop minor HIV-1-associated neurocognitive disorders. Neurological complications during HIV-1 infection are the result of direct neuronal damage by proinflammatory products released from HIV-1-infected or -un...

journal_title：Journal of neuroinflammation

authors： Mehla R,Bivalkar-Mehla S,Nagarkatti M,Chauhan A

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. ...

journal_title：Journal of neuroinflammation

authors： Grovola MR,Paleologos N,Wofford KL,Harris JP,Browne KD,Johnson V,Duda JE,Wolf JA,Cullen DK

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:A key feature of the inflammatory response after cerebral ischemia is the brain infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood: CCR2+Ly6Chi "inflammatory" monocytes involved in acute inflammation, and CX3CR1+Ly6Clo "patrolling" monocytes, which may play a role in repa...

journal_title：Journal of neuroinflammation

authors： Garcia-Bonilla L,Faraco G,Moore J,Murphy M,Racchumi G,Srinivasan J,Brea D,Iadecola C,Anrather J

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

journal_title：Journal of neuroinflammation

authors： Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

更新日期：2020-08-10 00:00:00

abstract：:BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respon...

journal_title：Journal of neuroinflammation

authors： Wu SZ,Bodles AM,Porter MM,Griffin WS,Basile AS,Barger SW

更新日期：2004-04-20 00:00:00

abstract：BACKGROUND:The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Microglia and astrocytes are likely to play a significant role in viral encephalitis pathophysiology as they are ideally positioned to respond to invading central nervous system (CNS) pathogens by producing k...

journal_title：Journal of neuroinflammation

authors： Furr SR,Chauhan VS,Moerdyk-Schauwecker MJ,Marriott I

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potentia...

journal_title：Journal of neuroinflammation

authors： Cho H,Hartsock MJ,Xu Z,He M,Duh EJ

更新日期：2015-12-21 00:00:00

abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

journal_title：Journal of neuroinflammation

authors： Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

更新日期：2017-09-25 00:00:00

abstract：BACKGROUND:The CD133(+) stem cell population in recurrent gliomas is associated with clinical features such as therapy resistance, blood-brain barrier disruption and, hence, tumor infiltration. Screening of a large panel of glioma samples increasing histological grade demonstrated frequencies of CD133(+) cells which co...

journal_title：Journal of neuroinflammation

authors： Annabi B,Laflamme C,Sina A,Lachambre MP,Béliveau R

更新日期：2009-03-09 00:00:00

abstract：BACKGROUND:Cranial radiotherapy is used to treat tumors of the central nervous system (CNS), as well as non-neoplastic conditions such as arterio-venous malformations; however, its use is limited by the tolerance of adjacent normal CNS tissue, which can lead to devastating long-term sequelae for patients. Despite decad...

journal_title：Journal of neuroinflammation

authors： Moravan MJ,Olschowka JA,Williams JP,O'Banion MK

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. with host defense mechanisms are poorly understood. This study addressed Ureaplasma-driven...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Haarmann A,Fehrholz M,Claus H,Speer CP,Glaser K

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

journal_title：Journal of neuroinflammation

authors： Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophages ...

journal_title：Journal of neuroinflammation

authors： Chu T,Zhang YP,Tian Z,Ye C,Zhu M,Shields LBE,Kong M,Barnes GN,Shields CB,Cai J

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00

abstract：:Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balance between the adverse effects of medication and the need to pr...

journal_title：Journal of neuroinflammation

authors： Liu CH,Zhang GZ,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer's disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharmacological antagonism ...

journal_title：Journal of neuroinflammation

authors： Ryu JK,Cho T,Choi HB,Jantaratnotai N,McLarnon JG

更新日期：2015-08-09 00:00:00

abstract：BACKGROUND:The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. METHODS:Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients...

journal_title：Journal of neuroinflammation

authors： Martinez-Martinez L,Lleixà MC,Boera-Carnicero G,Cortese A,Devaux J,Siles A,Rajabally Y,Martinez-Piñeiro A,Carvajal A,Pardo J,Delmont E,Attarian S,Diaz-Manera J,Callegari I,Marchioni E,Franciotta D,Benedetti L,Lauria G,

更新日期：2017-11-16 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00

abstract：:The role of inflammation in Alzheimer's disease (AD) has been controversial since its first consideration. As with most instances of neuroinflammation, the possibility must be considered that activation of glia and cytokine networks in AD arises merely as a reaction to neurodegeneration. Active, healthy neurons produc...

journal_title：Journal of neuroinflammation

authors： Barger SW

更新日期：2005-01-11 00:00:00

abstract：BACKGROUND:Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallmark of Parkinson's disease (PD). The pathogenesis of this type of neurological disorders often involv...

journal_title：Journal of neuroinflammation

authors： Liu RP,Zou M,Wang JY,Zhu JJ,Lai JM,Zhou LL,Chen SF,Zhang X,Zhu JH

更新日期：2014-03-12 00:00:00

abstract：AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

journal_title：Journal of neuroinflammation

authors： Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

更新日期：2020-01-24 00:00:00