Cerebral ischemic damage in diabetes: an inflammatory perspective.

abstract：BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

journal_title：Journal of neuroinflammation

authors： Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model. METHODS:In both control and endotoxinemic (5 mg/kg li...

journal_title：Journal of neuroinflammation

authors： Mihaylova S,Killian A,Mayer K,Pullamsetti SS,Schermuly R,Rosengarten B

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration w...

journal_title：Journal of neuroinflammation

authors： Vogel DY,Heijnen PD,Breur M,de Vries HE,Tool AT,Amor S,Dijkstra CD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. METHODS:Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients...

journal_title：Journal of neuroinflammation

authors： Martinez-Martinez L,Lleixà MC,Boera-Carnicero G,Cortese A,Devaux J,Siles A,Rajabally Y,Martinez-Piñeiro A,Carvajal A,Pardo J,Delmont E,Attarian S,Diaz-Manera J,Callegari I,Marchioni E,Franciotta D,Benedetti L,Lauria G,

更新日期：2017-11-16 00:00:00

abstract：:Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain disorder characterized by recurrent seizures originating from the hippocampus. The pathogenic mechanisms underlying mTLE remain largely unknown. Recent clinical and experimental evidence supports a role of various inflammatory media...

journal_title：Journal of neuroinflammation

authors： Kan AA,de Jager W,de Wit M,Heijnen C,van Zuiden M,Ferrier C,van Rijen P,Gosselaar P,Hessel E,van Nieuwenhuizen O,de Graan PN

更新日期：2012-08-30 00:00:00

abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...

journal_title：Journal of neuroinflammation

authors： Watkins LM,Neal JW,Loveless S,Michailidou I,Ramaglia V,Rees MI,Reynolds R,Robertson NP,Morgan BP,Howell OW

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. METHODS:We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: ...

journal_title：Journal of neuroinflammation

authors： Feng Q,Li L,Li M,Wang X

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who ha...

journal_title：Journal of neuroinflammation

authors： Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SH

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role in this process. In addition, cytokines and chemokines influence the phenotype of infiltrating imm...

journal_title：Journal of neuroinflammation

authors： Li L,Ni L,Heary RF,Elkabes S

更新日期：2020-02-25 00:00:00

abstract：BACKGROUND:This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. METHODS:Expression levels of proinflammatory cytokines were tested by QT-PCR and ELISA, levels of IDOs were...

journal_title：Journal of neuroinflammation

authors： Jiang X,Xu L,Tang L,Liu F,Chen Z,Zhang J,Chen L,Pang C,Yu X

更新日期：2018-01-04 00:00:00

abstract：:Oral atorvastatin has prevented or reversed paralysis in the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE), and reduced development of new MS lesions in clinical trials. Besides inhibiting development of encephalitogenic T cells, atorvastatin treatment of EAE has been associated with an...

journal_title：Journal of neuroinflammation

authors： Weber MS,Prod'homme T,Youssef S,Dunn SE,Steinman L,Zamvil SS

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimmune encephalomyelitis (EAE), ...

journal_title：Journal of neuroinflammation

authors： Serguera C,Stimmer L,Fovet CM,Horellou P,Contreras V,Tchitchek N,Massonneau J,Leroy C,Perrin A,Flament J,Hantraye P,Demilly J,Marignier R,Chrétien P,Hart B,Boutonnat J,Adam C,Le-Grand R,Deiva K

更新日期：2019-11-30 00:00:00

abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...

journal_title：Journal of neuroinflammation

authors： Yang F,Sun W,Yang Y,Wang Y,Li CL,Fu H,Wang XL,Yang F,He T,Chen J

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS). The aim of the present study was to apprai...

journal_title：Journal of neuroinflammation

authors： Teixeira NB,Picolo G,Giardini AC,Boumezbeur F,Pottier G,Kuhnast B,Servent D,Benoit E

更新日期：2020-09-07 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. METHODS:A perioperative neurocognitive disorders (PND) mouse model was generated...

journal_title：Journal of neuroinflammation

authors： Li D,Chen M,Meng T,Fei J

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

journal_title：Journal of neuroinflammation

authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer's disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD:In this study, we investigated Aβ-effects on heat s...

journal_title：Journal of neuroinflammation

authors： Lamoke F,Mazzone V,Persichini T,Maraschi A,Harris MB,Venema RC,Colasanti M,Gliozzi M,Muscoli C,Bartoli M,Mollace V

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophages ...

journal_title：Journal of neuroinflammation

authors： Chu T,Zhang YP,Tian Z,Ye C,Zhu M,Shields LBE,Kong M,Barnes GN,Shields CB,Cai J

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apo...

journal_title：Journal of neuroinflammation

authors： Shrivastava P,Cabrera MA,Chastain LG,Boyadjieva NI,Jabbar S,Franklin T,Sarkar DK

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instruc...

journal_title：Journal of neuroinflammation

authors： Welser JV,Halder SK,Kant R,Boroujerdi A,Milner R

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of b...

journal_title：Journal of neuroinflammation

authors： Wijenayake S,Rahman MF,Lum CMW,De Vega WC,Sasaki A,McGowan PO

更新日期：2020-04-15 00:00:00

abstract：:BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respon...

journal_title：Journal of neuroinflammation

authors： Wu SZ,Bodles AM,Porter MM,Griffin WS,Basile AS,Barger SW

更新日期：2004-04-20 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for ...

journal_title：Journal of neuroinflammation

authors： Chen X,Wu S,Chen C,Xie B,Fang Z,Hu W,Chen J,Fu H,He H

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Pharmaceutical treatment with probable anti-inflammatory substances that attack cells in various ways including receptors, ion channels, or transporter systems may slow down the progression of inflammatory conditions. Astrocytes and microglia are the most prominent target cells for inflammation in the centra...

journal_title：Journal of neuroinflammation

authors： Hansson E,Björklund U,Skiöldebrand E,Rönnbäck L

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is an important regulator of g...

journal_title：Journal of neuroinflammation

authors： Straccia M,Gresa-Arribas N,Dentesano G,Ejarque-Ortiz A,Tusell JM,Serratosa J,Solà C,Saura J

更新日期：2011-11-10 00:00:00

abstract：:Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic pain accelerates AD pathogenesis. In this review, we provide evidence th...

journal_title：Journal of neuroinflammation

authors： Cao S,Fisher DW,Yu T,Dong H

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:Interleukin-1 beta converting enzyme (ICE, caspase 1) is a cysteine protease that processes immature pro-IL-1β into active mature IL-1β. IL-1β is a pro-inflammatory cytokine that mediates many of the physiological and behavioral responses to inflammation. Genetic deletion of ICE has previously been shown to ...

journal_title：Journal of neuroinflammation

authors： Lawson MA,McCusker RH,Kelley KW

更新日期：2013-05-01 00:00:00