Abstract：
BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who had taken CYT (0.01 g/kg) 3 times a day after meals for 2 weeks by oral administration. For ex vivo experiments, peripheral blood mononuclear cells (PBMCs) were isolated from CI patients. We analyzed the effect of CYT and its main components on lipopolysaccharide (LPS)-induced cytokine production and mechanism on PBMCs of CI patients by using ELISA, western blot analysis, transcription factor enzyme-linked immunoassay, and caspase assay. RESULTS:Clinical signs of CI significantly disappeared about 2 weeks after oral administration of CYT to CI patients (P < 0.05). CYT and quercetin, an active compound of CYT, significantly inhibited LPS-induced interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α production and expression in PBMCs. CYT and quercetin also inhibited LPS-induced nuclear translocation and DNA binding activities of nuclear factor-κB and degradation of IκBα. In addition, CYT and quercetin inhibited LPS-induced IL-32 expression and caspase-1 activation. CONCLUSION:These results suggest a mechanism that might explain the beneficial effect of CYT in treating CI patients. Taken together, our findings indicate that inhibition of IL-32 expression and caspase-1 activation may be a novel biomarker and potential therapeutic target in CI.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SHdoi
10.1186/1742-2094-7-85subject
Has Abstractpub_date
2010-11-25 00:00:00pages
85issn
1742-2094pii
1742-2094-7-85journal_volume
7pub_type
杂志文章abstract：BACKGROUND:Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain. However, whether it contribu...
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-02009-7
更新日期：2020-11-12 00:00:00
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0452-z
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journal_title：Journal of neuroinflammation
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doi：10.1186/s12974-020-01907-0
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
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journal_title：Journal of neuroinflammation
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-014-0149-8
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1514-4
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0755-8
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journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01733-4
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pub_type： 杂志文章
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更新日期：2019-02-12 00:00:00
