Abstract:
OBJECTIVES:Autism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers. MATERIALS AND METHODS:Na+, K+, Ca2+, Mg2+, Na+/K+, Ca2+/Mg2+ together with IL6, TNFα as proinflammatory cytokines and caspase3 as proapoptotic biomarker were determined in plasma of 25 Saudi autistic male patients and compared to 16 age and gender matching control samples. RESULTS:The obtained data recorded that Saudi autistic patients have a remarkable lower plasma caspase3, IL6, TNFα, Ca2+ and a significantly higher K+ compared to age and gender matching controls. On the other hand both Mg2+ and Na+ were non-significantly altered in autistic patients. Pearson correlations revealed that plasma concentrations of the measured cytokines and caspase-3 were positively correlated with Ca2+ and Ca2+/K+ ratio. Reciever Operating Characteristics (ROC) analysis proved that the measured parameters recorded satisfactory levels of specificity and sensitivity. CONCLUSION:Alteration of the selected measured ions confirms that oxidative stress and defective mitochondrial energy production could be contributed in the pathogenesis of autism. Moreover, it highlights the relationship between the measured ions, IL6, TNFα and caspase3 as a set of signalling pathways that might have a role in generating this increasingly prevalent disorder. The role of ions in the possible proinflammation and proapoptic mechanisms of autistics' brains were hypothesized and explained.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
El-Ansary AK,Ben Bacha AG,Al-Ayadhi LYdoi
10.1186/1742-2094-8-142subject
Has Abstractpub_date
2011-10-15 00:00:00pages
142issn
1742-2094pii
1742-2094-8-142journal_volume
8pub_type
杂志文章abstract::Human immunodeficiency virus type 1 (HIV) continues to be one of the most prevalent global health afflictions to date. The advent and introduction of combined antiretroviral therapy (cART) has made a significant impact on the course of infection. However, as patients are living longer, many HIV-associated illnesses ar...
journal_title:Journal of neuroinflammation
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2019-02-12 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/1742-2094-10-54
更新日期:2013-05-01 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
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更新日期:2017-11-09 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/s12974-016-0666-8
更新日期:2016-08-26 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-07-06 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
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更新日期:2007-07-02 00:00:00
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