Neutrophil contribution to spinal cord injury and repair.

abstract：BACKGROUND:Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential for the treatment of this syndrome, possibly through regenerative actions on peripheral nerves. Here,...

journal_title：Journal of neuroinflammation

authors： Evangelista AF,Vannier-Santos MA,de Assis Silva GS,Silva DN,Juiz PJL,Nonaka CKV,Dos Santos RR,Soares MBP,Villarreal CF

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of b...

journal_title：Journal of neuroinflammation

authors： Wijenayake S,Rahman MF,Lum CMW,De Vega WC,Sasaki A,McGowan PO

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...

journal_title：Journal of neuroinflammation

authors： Das Sarma J,Ciric B,Marek R,Sadhukhan S,Caruso ML,Shafagh J,Fitzgerald DC,Shindler KS,Rostami A

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Fenofibrate, a PPAR-α activator, has shown promising results as a neuroprotective therapy, with proposed anti-inflammatory and anti-oxidant effects. However, it displays poor blood-brain barrier permeability leading to some ambiguity over its mechanism of action. Experimentally induced brain injury has been ...

journal_title：Journal of neuroinflammation

authors： Losey P,Ladds E,Laprais M,Guevel B,Burns L,Bordet R,Anthony DC

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory reaction plays a crucial role in cerebral ischemia reperfusion (IR) injury. It has been shown that activated microglia long-term existed in cerebral ischemia and induced second injury. Therefore, we hypothesize that prepared phosphatidylserine (PS)-modified microbubbles (PS-MBs) comb...

journal_title：Journal of neuroinflammation

authors： Zhao R,Jiang J,Li H,Chen M,Liu R,Sun S,Ma,Liang X,Wang S

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between t...

journal_title：Journal of neuroinflammation

authors： Haile Y,Deng X,Ortiz-Sandoval C,Tahbaz N,Janowicz A,Lu JQ,Kerr BJ,Gutowski NJ,Holley JE,Eggleton P,Giuliani F,Simmen T

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

journal_title：Journal of neuroinflammation

authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic hemichannels and gap junction...

journal_title：Journal of neuroinflammation

authors： Yin X,Feng L,Ma D,Yin P,Wang X,Hou S,Hao Y,Zhang J,Xin M,Feng J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Neuroinflammation is considered a risk factor for impairments in neuronal function and cognition that arise with trauma, infection, and/or disease. IL-17A has been determined to be involved in neurodegenerative diseases such as multiple sclerosis. Recently, IL-17A has been shown to be upregulated in lipopoly...

journal_title：Journal of neuroinflammation

authors： Sun J,Zhang S,Zhang X,Zhang X,Dong H,Qian Y

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflammation, in vivo. The second generation PET radioligand [18F]DPA714 binds with hi...

journal_title：Journal of neuroinflammation

authors： Hagens MHJ,Golla SV,Wijburg MT,Yaqub M,Heijtel D,Steenwijk MD,Schober P,Brevé JJP,Schuit RC,Reekie TA,Kassiou M,van Dam AM,Windhorst AD,Killestein J,Barkhof F,van Berckel BNM,Lammertsma AA

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

journal_title：Journal of neuroinflammation

authors： Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer's disease (AD); however, VCID is commonly found as a co-morbidity with sporadic AD. We have previously established a mouse model of VCID by inducing hyperhomocysteinemia in both w...

journal_title：Journal of neuroinflammation

authors： Weekman EM,Sudduth TL,Price BR,Woolums AE,Hawthorne D,Seaks CE,Wilcock DM

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) makes a great contribution to host defense and inflammation. In many settings, lipopolysaccharide (LPS) induces iNOS expression through activation of the inhibitor of κB-α (IκB-α)-nuclear factor-κB (NF-κB) cascade, whereas interferon-γ (IFN-γ) acts through Janus kinase ...

journal_title：Journal of neuroinflammation

authors： Huang C,Lu X,Tong L,Wang J,Zhang W,Jiang B,Yang R

更新日期：2015-10-14 00:00:00

abstract：:Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary infla...

journal_title：Journal of neuroinflammation

authors： Wang PF,Xiong XY,Chen J,Wang YC,Duan W,Yang QW

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...

journal_title：Journal of neuroinflammation

authors： Dong T,Zhi L,Bhayana B,Wu MX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Both dysfunctional neuropeptide signaling and immune system activation are characteristic of complex regional pain syndrome (CRPS). Unknown is whether substance P (SP) or calcitonin gene-related peptide (CGRP) support autoantibody production and, consequently, nociceptive sensitization. METHODS:These experi...

journal_title：Journal of neuroinflammation

authors： Li WW,Guo TZ,Shi X,Birklein F,Schlereth T,Kingery WS,Clark JD

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration w...

journal_title：Journal of neuroinflammation

authors： Vogel DY,Heijnen PD,Breur M,de Vries HE,Tool AT,Amor S,Dijkstra CD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potentia...

journal_title：Journal of neuroinflammation

authors： Cho H,Hartsock MJ,Xu Z,He M,Duh EJ

更新日期：2015-12-21 00:00:00

abstract：BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

journal_title：Journal of neuroinflammation

authors： Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...

journal_title：Journal of neuroinflammation

authors： Hinojosa AE,Caso JR,García-Bueno B,Leza JC,Madrigal JL

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

journal_title：Journal of neuroinflammation

authors： Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:The mechanism of leukocyte transendothelial migration (TEM) across the highly restrictive blood-brain barrier (BBB) remains enigmatic, with paracellular TEM thought to require leukocytes to somehow navigate the obstructive endothelial tight junctions (TJs). Transient interactions between TJ proteins on the r...

journal_title：Journal of neuroinflammation

authors： Paul D,Baena V,Ge S,Jiang X,Jellison ER,Kiprono T,Agalliu D,Pachter JS

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

journal_title：Journal of neuroinflammation

authors： Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS:We studied the HLA-B & C a...

journal_title：Journal of neuroinflammation

authors： Lehmann DJ,Barnardo MC,Fuggle S,Quiroga I,Sutherland A,Warden DR,Barnetson L,Horton R,Beck S,Smith AD

更新日期：2006-12-18 00:00:00

abstract：:The role of inflammation in Alzheimer's disease (AD) has been controversial since its first consideration. As with most instances of neuroinflammation, the possibility must be considered that activation of glia and cytokine networks in AD arises merely as a reaction to neurodegeneration. Active, healthy neurons produc...

journal_title：Journal of neuroinflammation

authors： Barger SW

更新日期：2005-01-11 00:00:00

abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...

journal_title：Journal of neuroinflammation

authors： Guo Z,Yu S,Xiao L,Chen X,Ye R,Zheng P,Dai Q,Sun W,Zhou C,Wang S,Zhu W,Liu X

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inhibitor approved in th...

journal_title：Journal of neuroinflammation

authors： Gavegnano C,Haile WB,Hurwitz S,Tao S,Jiang Y,Schinazi RF,Tyor WR

更新日期：2019-09-27 00:00:00

abstract：:Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

journal_title：Journal of neuroinflammation

authors： Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2020-02-12 00:00:00