Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples.


BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their associated immunotherapy was increased exponentially in recent years. Gliomas provide clinical targets for immunotherapy during the search of key regulators of immune response. Our study focused on the human leukocyte antigen (HLA) system that is responsible for regulating the immune system, and discovered the relationship between HLA-F expression and clinical prognosis in gliomas. METHODS:A total of 593 patients with gliomas were included in our research. Of these, 325 patients were from the Chinese Glioma Genome Atlas (CGGA) and 268 were from the GSE 16011 set. Kaplan-Meier (KM) analysis was performed to explore the prognostic value of HLA-F. t test analysis was used to find the distribution difference in various groups. R language packages are used for other statistical computations and figure drawing. RESULTS:HLA-F was negatively correlated with overall survival (OS) in all grades of glioma and glioblastoma (GBM). Moreover, HLA-F was enriched in GBM and isocitrate dehydrogenase 1 wild-type (IDH1 wt) group and considered HLA-F as a mesenchymal subtype marker. Pearson correlation test showed that HLA-F was correlated with other HLA-I molecules. CONCLUSION:HLA-F expression was positively correlated with malignant phenotype and negatively correlated with OS, indicating that HLA-F could predict the immune state of gliomas and might be a clinical target of glioma immunotherapy.


J Neuroinflammation


Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G




Has Abstract


2019-02-12 00:00:00












  • Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients.

    abstract:BACKGROUND:Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an imbalance between pro- and anti-inflammatory mediators in the brain. We examined whether hip fracture patients who develop postoperative delirium have altered...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Westhoff D,Witlox J,Koenderman L,Kalisvaart KJ,de Jonghe JF,van Stijn MF,Houdijk AP,Hoogland IC,Maclullich AM,van Westerloo DJ,van de Beek D,Eikelenboom P,van Gool WA

    更新日期:2013-10-07 00:00:00

  • Differential neurovirulence of Usutu virus lineages in mice and neuronal cells.

    abstract:BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

    更新日期:2021-01-06 00:00:00

  • The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial.

    abstract:BACKGROUND:Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Singh N,Hopkins SJ,Hulme S,Galea JP,Hoadley M,Vail A,Hutchinson PJ,Grainger S,Rothwell NJ,King AT,Tyrrell PJ

    更新日期:2014-01-03 00:00:00

  • All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.

    abstract:BACKGROUND AND PURPOSE:Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neuroprotection remain elusive. ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Cai W,Wang J,Hu M,Chen X,Lu Z,Bellanti JA,Zheng SG

    更新日期:2019-08-31 00:00:00

  • Thalamocortical-auditory network alterations following cuprizone-induced demyelination.

    abstract:BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

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  • Association of brain immune genes with social behavior of inbred mouse strains.

    abstract:BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

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  • Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population.

    abstract:INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

    更新日期:2012-09-28 00:00:00

  • Increased frequency of IL-6-producing non-classical monocytes in neuromyelitis optica spectrum disorder.

    abstract:BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

    更新日期:2017-09-25 00:00:00

  • Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning.

    abstract:BACKGROUND:Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, ov...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: De Luca SN,Ziko I,Sominsky L,Nguyen JC,Dinan T,Miller AA,Jenkins TA,Spencer SJ

    更新日期:2016-05-18 00:00:00

  • Anti-inflammatory response following uptake of apoptotic bodies by meningothelial cells.

    abstract:BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Li J,Fang L,Meyer P,Killer HE,Flammer J,Neutzner A

    更新日期:2014-02-24 00:00:00

  • Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.

    abstract:BACKGROUND:Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adap...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Kurhade C,Zegenhagen L,Weber E,Nair S,Michaelsen-Preusse K,Spanier J,Gekara NO,Kröger A,Överby AK

    更新日期:2016-01-27 00:00:00

  • Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats.

    abstract:BACKGROUND:Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective treatment to inhibit the...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Jiang L,Pan CL,Wang CY,Liu BQ,Han Y,Hu L,Liu L,Yang Y,Qu JW,Liu WT

    更新日期:2017-08-31 00:00:00

  • Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1.

    abstract:BACKGROUND:Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of ischemic disease. This work defines the contributions of each of the ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Orsini F,Chrysanthou E,Dudler T,Cummings WJ,Takahashi M,Fujita T,Demopulos G,De Simoni MG,Schwaeble W

    更新日期:2016-08-30 00:00:00

  • Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.

    abstract:BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

    更新日期:2018-09-25 00:00:00

  • LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

    abstract:BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

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  • Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

    abstract:BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged inflammatory response via its recognition by micr...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: El Hajj H,Savage JC,Bisht K,Parent M,Vallières L,Rivest S,Tremblay MÈ

    更新日期:2019-04-16 00:00:00

  • Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway.

    abstract:BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

    更新日期:2021-01-06 00:00:00

  • Cerebral ischemic damage in diabetes: an inflammatory perspective.

    abstract::Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,评审


    authors: Shukla V,Shakya AK,Perez-Pinzon MA,Dave KR

    更新日期:2017-01-23 00:00:00

  • The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.

    abstract::Multiple sclerosis (MS) is thought to be a CD4+ T cell mediated autoimmune demyelinating disease of the central nervous system (CNS) that is rarely diagnosed during infancy. Cellular and molecular mechanisms that confer disease resistance in this age group are unknown. We tested the hypothesis that a differential comp...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Cravens PD,Kieseier BC,Hussain R,Herndon E,Arellano B,Ben LH,Timmons BC,Castro-Rojas C,Hartung HP,Hemmer B,Weber MS,Zamvil SS,Stüve O

    更新日期:2013-05-24 00:00:00

  • Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study.

    abstract:BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

    更新日期:2010-11-17 00:00:00

  • Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-α levels.

    abstract:BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

    更新日期:2014-09-03 00:00:00

  • Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients.

    abstract:BACKGROUND:Activation of hyaluronic acid (HA) and associated enzyme synthesis has been demonstrated in experimental stroke animal models. Our study aimed to investigate the plasma levels of HA in acute stroke patients and the associations between HA levels and functional outcome. METHODS:This was a multicenter case-co...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章,多中心研究


    authors: Tang SC,Yeh SJ,Tsai LK,Hu CJ,Lien LM,Peng GS,Yang WS,Chiou HY,Jeng JS

    更新日期:2014-06-10 00:00:00

  • Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling.

    abstract:BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

    更新日期:2014-07-28 00:00:00

  • Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators.

    abstract:BACKGROUND:Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammat...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Hinojosa AE,Caso JR,García-Bueno B,Leza JC,Madrigal JL

    更新日期:2013-07-09 00:00:00

  • Neuroinflammation in autism spectrum disorders.

    abstract:OBJECTIVES:The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, C...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: El-Ansary A,Al-Ayadhi L

    更新日期:2012-12-11 00:00:00

  • Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.

    abstract:BACKGROUND:Therapeutic modalities effective in patients with progressive forms of multiple sclerosis (MS) are limited. In a murine model of progressive MS, the sustained disability during the chronic phase of experimental autoimmune encephalomyelitis (EAE) correlated with elevated expression of interleukin (IL)-6, a cy...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Savarin C,Hinton DR,Valentin-Torres A,Chen Z,Trapp BD,Bergmann CC,Stohlman SA

    更新日期:2015-04-22 00:00:00

  • In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study.

    abstract:BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

    更新日期:2017-03-29 00:00:00

  • Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?

    abstract:BACKGROUND:Neuroinflammation in utero may contribute to brain injury resulting in life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) in controlling inflammation, e.g., by inhibiting the HMGB1 release, via the macrophages' α7 nicotinic acetylcholine receptor...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Frasch MG,Szynkaruk M,Prout AP,Nygard K,Cao M,Veldhuizen R,Hammond R,Richardson BS

    更新日期:2016-05-10 00:00:00

  • Interleukin-17 impedes Schwann cell-mediated myelination.

    abstract:BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Stettner M,Lohmann B,Wolffram K,Weinberger JP,Dehmel T,Hartung HP,Mausberg AK,Kieseier BC

    更新日期:2014-03-29 00:00:00

  • CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis.

    abstract:BACKGROUND:The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of C/EBPδ durin...

    journal_title:Journal of neuroinflammation

    pub_type: 杂志文章


    authors: Valls Serón M,Duitman J,Geldhoff M,Engelen-Lee J,Havik SR,Brouwer MC,van de Beek D,Spek CA

    更新日期:2015-05-10 00:00:00