Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease.

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer's disease (AD); however, VCID is commonly found as a co-morbidity with sporadic AD. We have previously established a mouse model of VCID by inducing hyperhomocysteinemia in both w...

journal_title：Journal of neuroinflammation

authors： Weekman EM,Sudduth TL,Price BR,Woolums AE,Hawthorne D,Seaks CE,Wilcock DM

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer's disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD:In this study, we investigated Aβ-effects on heat s...

journal_title：Journal of neuroinflammation

authors： Lamoke F,Mazzone V,Persichini T,Maraschi A,Harris MB,Venema RC,Colasanti M,Gliozzi M,Muscoli C,Bartoli M,Mollace V

更新日期：2015-05-03 00:00:00

abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...

journal_title：Journal of neuroinflammation

authors： Cheng Z,Wang L,Qu M,Liang H,Li W,Li Y,Deng L,Zhang Z,Yang GY

更新日期：2018-05-03 00:00:00

abstract：BACKGROUND:Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental i...

journal_title：Journal of neuroinflammation

authors： Moidunny S,Matos M,Wesseling E,Banerjee S,Volsky DJ,Cunha RA,Agostinho P,Boddeke HW,Roy S

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (statin-Dex) on EAMG are still unk...

journal_title：Journal of neuroinflammation

authors： Li XL,Li H,Zhang M,Xu H,Yue LT,Zhang XX,Wang S,Wang CC,Li YB,Dou YC,Duan RS

更新日期：2016-01-12 00:00:00

abstract：:Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric...

journal_title：Journal of neuroinflammation

authors： Najjar S,Pearlman DM,Alper K,Najjar A,Devinsky O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but are not a quickly measured serum inflammatory or neuronal biomarkers to rapidly a...

journal_title：Journal of neuroinflammation

authors： Borjini N,Sivilia S,Giuliani A,Fernandez M,Giardino L,Facchinetti F,Calzà L

更新日期：2019-10-28 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

journal_title：Journal of neuroinflammation

authors： Alabdali A,Al-Ayadhi L,El-Ansary A

更新日期：2014-01-08 00:00:00

abstract：BACKGROUND:Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternativ...

journal_title：Journal of neuroinflammation

authors： Xu S,Zhu W,Shao M,Zhang F,Guo J,Xu H,Jiang J,Ma X,Xia X,Zhi X,Zhou P,Lu F

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer's disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharmacological antagonism ...

journal_title：Journal of neuroinflammation

authors： Ryu JK,Cho T,Choi HB,Jantaratnotai N,McLarnon JG

更新日期：2015-08-09 00:00:00

abstract：BACKGROUND:Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underl...

journal_title：Journal of neuroinflammation

authors： Yasui M,Menjyo Y,Tokizane K,Shiozawa A,Tsuda M,Inoue K,Kiyama H

更新日期：2019-03-30 00:00:00

abstract：:Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unknown how synaptic ac...

journal_title：Journal of neuroinflammation

authors： Yan X,Jiang E,Weng HR

更新日期：2015-01-09 00:00:00

abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...

journal_title：Journal of neuroinflammation

authors： Mayado A,Torres E,Gutierrez-Lopez MD,Colado MI,O'Shea E

更新日期：2011-11-24 00:00:00

abstract：:The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome is a member of the NLR family of innate immune cell sensors. These are crucial regulators of cytokine secretions, which promote ischemic cell death and insulin resistance. This review summarizes rece...

journal_title：Journal of neuroinflammation

authors： Hong P,Gu RN,Li FX,Xiong XX,Liang WB,You ZJ,Zhang HF

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:Human marrow stromal cells (hMSCs) injected intrathecally can effectively increase the lifespan and protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis. However, how the transplanted cells exert a neuroprotective effect is still unclear. More recently, the anti-inflammation eff...

journal_title：Journal of neuroinflammation

authors： Zhou C,Zhang C,Zhao R,Chi S,Ge P,Zhang C

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:In brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the initial events triggered by inflammation or oxidative stress that provoke axonal damage is critical for the development of neuroprotective therapies. Energy...

journal_title：Journal of neuroinflammation

authors： Errea O,Moreno B,Gonzalez-Franquesa A,Garcia-Roves PM,Villoslada P

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines...

journal_title：Journal of neuroinflammation

authors： Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in...

journal_title：Journal of neuroinflammation

authors： Dukay B,Walter FR,Vigh JP,Barabási B,Hajdu P,Balassa T,Migh E,Kincses A,Hoyk Z,Szögi T,Borbély E,Csoboz B,Horváth P,Fülöp L,Penke B,Vígh L,Deli MA,Sántha M,Tóth ME

更新日期：2021-01-10 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such as neuroinflammation, in vivo. The second generation PET radioligand [18F]DPA714 binds with hi...

journal_title：Journal of neuroinflammation

authors： Hagens MHJ,Golla SV,Wijburg MT,Yaqub M,Heijtel D,Steenwijk MD,Schober P,Brevé JJP,Schuit RC,Reekie TA,Kassiou M,van Dam AM,Windhorst AD,Killestein J,Barkhof F,van Berckel BNM,Lammertsma AA

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (AS...

journal_title：Journal of neuroinflammation

authors： Jyonouchi H,Geng L,Davidow AL

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:A key feature of the inflammatory response after cerebral ischemia is the brain infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood: CCR2+Ly6Chi "inflammatory" monocytes involved in acute inflammation, and CX3CR1+Ly6Clo "patrolling" monocytes, which may play a role in repa...

journal_title：Journal of neuroinflammation

authors： Garcia-Bonilla L,Faraco G,Moore J,Murphy M,Racchumi G,Srinivasan J,Brea D,Iadecola C,Anrather J

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induction of depression-like behaviors in animal models. Several studies hav...

journal_title：Journal of neuroinflammation

authors： Brooks AK,Lawson MA,Smith RA,Janda TM,Kelley KW,McCusker RH

更新日期：2016-05-03 00:00:00

abstract：:Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balance between the adverse effects of medication and the need to pr...

journal_title：Journal of neuroinflammation

authors： Liu CH,Zhang GZ,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, IL-1β, and N-methyl D-aspartate receptor subunit 2B (NR2B) genes in cochlea and inferior colliculus (...

journal_title：Journal of neuroinflammation

authors： Hwang JH,Chen JC,Yang SY,Wang MF,Chan YC

更新日期：2011-04-09 00:00:00

abstract：BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

journal_title：Journal of neuroinflammation

authors： Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

更新日期：2017-12-12 00:00:00