Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat.

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

journal_title：Journal of neuroinflammation

authors： Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but are not a quickly measured serum inflammatory or neuronal biomarkers to rapidly a...

journal_title：Journal of neuroinflammation

authors： Borjini N,Sivilia S,Giuliani A,Fernandez M,Giardino L,Facchinetti F,Calzà L

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimmune encephalomyelitis (EAE), ...

journal_title：Journal of neuroinflammation

authors： Serguera C,Stimmer L,Fovet CM,Horellou P,Contreras V,Tchitchek N,Massonneau J,Leroy C,Perrin A,Flament J,Hantraye P,Demilly J,Marignier R,Chrétien P,Hart B,Boutonnat J,Adam C,Le-Grand R,Deiva K

更新日期：2019-11-30 00:00:00

abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...

journal_title：Journal of neuroinflammation

authors： Dong T,Zhi L,Bhayana B,Wu MX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Inflammation is a critical process for the progression of neuronal death in neurodegenerative disorders. Microglia play a central role in neuroinflammation and may affect neuron vulnerability. Next generation sequencing has shown the molecular heterogeneity of microglial cells; however, the variability in th...

journal_title：Journal of neuroinflammation

authors： Abellanas MA,Zamarbide M,Basurco L,Luquin E,Garcia-Granero M,Clavero P,San Martin-Uriz P,Vilas A,Mengual E,Hervas-Stubbs S,Aymerich MS

更新日期：2019-11-22 00:00:00

abstract：BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

journal_title：Journal of neuroinflammation

authors： Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between t...

journal_title：Journal of neuroinflammation

authors： Haile Y,Deng X,Ortiz-Sandoval C,Tahbaz N,Janowicz A,Lu JQ,Kerr BJ,Gutowski NJ,Holley JE,Eggleton P,Giuliani F,Simmen T

更新日期：2017-01-23 00:00:00

abstract：OBJECTIVE:Converging lines of evidence point to the existence of immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key neurodevelopmental processes. Previous studies have shown higher cytokine levels in patients with autism compared with matched controls or subjects with other de...

journal_title：Journal of neuroinflammation

authors： Napolioni V,Ober-Reynolds B,Szelinger S,Corneveaux JJ,Pawlowski T,Ober-Reynolds S,Kirwan J,Persico AM,Melmed RD,Craig DW,Smith CJ,Huentelman MJ

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke...

journal_title：Journal of neuroinflammation

authors： Gautier S,Ouk T,Tagzirt M,Lefebvre C,Laprais M,Pétrault O,Dupont A,Leys D,Bordet R

更新日期：2014-05-27 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...

journal_title：Journal of neuroinflammation

authors： Guo Z,Yu S,Xiao L,Chen X,Ye R,Zheng P,Dai Q,Sun W,Zhou C,Wang S,Zhu W,Liu X

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. ...

journal_title：Journal of neuroinflammation

authors： Grovola MR,Paleologos N,Wofford KL,Harris JP,Browne KD,Johnson V,Duda JE,Wolf JA,Cullen DK

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

journal_title：Journal of neuroinflammation

authors： Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Activation of inflammation pathways in the brain occurs in Alzheimer's disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute to tau protein accumulation an...

journal_title：Journal of neuroinflammation

authors： Bennett RE,Bryant A,Hu M,Robbins AB,Hopp SC,Hyman BT

更新日期：2018-11-09 00:00:00

abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

journal_title：Journal of neuroinflammation

authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

更新日期：2007-02-26 00:00:00

abstract：BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

journal_title：Journal of neuroinflammation

authors： Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Buttmann M,Glaser K

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Chu JMT,Yan T,Zhang Y,Chen Y,Chang RCC,Wong GTC

更新日期：2020-01-03 00:00:00

abstract：BACKGROUND:Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO). In a previous study, we showed that the PKO mice were grossly normal under homeostatic condition, b...

journal_title：Journal of neuroinflammation

authors： Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Betaine (glycine betaine or trimethylglycine) plays important roles as an osmolyte and a methyl donor in animals. While betaine is reported to suppress expression of proinflammatory molecules and reduce oxidative stress in aged rat kidney, the effects of betaine on the central nervous system are not well kno...

journal_title：Journal of neuroinflammation

authors： Miwa M,Tsuboi M,Noguchi Y,Enokishima A,Nabeshima T,Hiramatsu M

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...

journal_title：Journal of neuroinflammation

authors： Das Sarma J,Ciric B,Marek R,Sadhukhan S,Caruso ML,Shafagh J,Fitzgerald DC,Shindler KS,Rostami A

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

journal_title：Journal of neuroinflammation

authors： Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the present study, we focused on the ...

journal_title：Journal of neuroinflammation

authors： Lee JH,Kim H,Woo JH,Joe EH,Jou I

更新日期：2012-02-18 00:00:00

abstract：BACKGROUND:The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role in this process. In addition, cytokines and chemokines influence the phenotype of infiltrating imm...

journal_title：Journal of neuroinflammation

authors： Li L,Ni L,Heary RF,Elkabes S

更新日期：2020-02-25 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects of oligodendrocytes in neurodegenerative diseases, it remains unknown whether ol...

journal_title：Journal of neuroinflammation

authors： Yue Y,Stanojlovic M,Lin Y,Karsenty G,Lin W

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways is a useful therapeut...

journal_title：Journal of neuroinflammation

authors： Jiang M,Li J,Peng Q,Liu Y,Liu W,Luo C,Peng J,Li J,Yung KK,Mo Z

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inhibitor approved in th...

journal_title：Journal of neuroinflammation

authors： Gavegnano C,Haile WB,Hurwitz S,Tao S,Jiang Y,Schinazi RF,Tyor WR

更新日期：2019-09-27 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00