Abstract：
BACKGROUND:Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO). In a previous study, we showed that the PKO mice were grossly normal under homeostatic condition, but developed blood-brain barrier (BBB) breakdown with advanced age (> 8 months), suggesting that these mutants are intrinsically weak. Based on these findings, we hypothesized that PKO mice have exacerbated injuries in pathological conditions. METHODS:Using collagenase-induced intracerebral hemorrhage (ICH) as an injury model, we examined various stroke outcomes, including hematoma volume, neurological function, neuronal death, BBB integrity, paracellular/transcellular transport, inflammatory cell infiltration, and brain water content, in PKO mice and their wildtype littermates at young age (6-8 weeks). In addition, transmission electron microscopy (TEM) analysis and an in vitro ICH model were used to investigate the underlying molecular mechanisms. RESULTS:Compared to age-matched wildtype littermates, PKO mice display aggravated stroke outcomes, including larger hematoma size, worse neurological function, increased neuronal cell death, enhanced BBB permeability, increased transcytosis, and elevated inflammatory cell infiltration. These mutants also exhibit high baseline brain water content independent of aquaporin-4 (AQP4). In addition, mural cell-derived laminin significantly reduced caveolin-1 without affecting tight junction proteins in the in vitro ICH model. CONCLUSIONS:These results suggest that mural cell-derived laminin attenuates BBB damage in ICH via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Ydoi
10.1186/s12974-020-01788-3subject
Has Abstractpub_date
2020-04-06 00:00:00pages
103issue
1issn
1742-2094pii
10.1186/s12974-020-01788-3journal_volume
17pub_type
杂志文章abstract：BACKGROUND:The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely involves chronic imm...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1320-4
更新日期：2018-10-10 00:00:00
abstract：BACKGROUND:Recent studies described a critical role for microglia in Parkinson's disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra. Understanding the phenotype switch of microgl...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1682-2
更新日期：2019-12-26 00:00:00
abstract：BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-gal...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01989-w
更新日期：2020-10-15 00:00:00
abstract：BACKGROUND:Kainic acid (KA)-induced status epilepticus (SE) was involved with release of free radicals. Sesamin is a well-known antioxidant from sesame seeds and it scavenges free radicals in several brain injury models. However the neuroprotective mechanism of sesamin to KA-induced seizure has not been studied. METHO...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-8-57
更新日期：2011-05-24 00:00:00
abstract：BACKGROUND:It has recently become apparent that neuroinflammation may play a significant role in Parkinson's disease (PD). This is also the case in animal paradigms of the disease. The potential neuroprotective action of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 (EX-4), which is protective against...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-5-19
更新日期：2008-05-21 00:00:00
abstract：BACKGROUND:Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-017-0923-5
更新日期：2017-07-21 00:00:00
abstract：BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-63
更新日期：2014-03-29 00:00:00
abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0611-x
更新日期：2016-06-22 00:00:00
abstract：:Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic pain accelerates AD pathogenesis. In this review, we provide evidence th...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-019-1608-z
更新日期：2019-11-06 00:00:00
abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1153-1
更新日期：2018-05-03 00:00:00
abstract：BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cel...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-53
更新日期：2014-03-22 00:00:00
abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-10-119
更新日期：2013-09-26 00:00:00
abstract：BACKGROUND:Ischemic stroke is a main cause of mortality. Blood-brain barrier (BBB) breakdown appears to play a critical role in inflammation in patients with ischemic stroke and acceleration of brain injury. The BBB has a protective function and is composed of endothelial cells, pericytes, and astrocytes. In ischemic s...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-1727-6
更新日期：2020-02-04 00:00:00
abstract：OBJECTIVES:Autism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and p...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-8-142
更新日期：2011-10-15 00:00:00
abstract：BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severit...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01733-4
更新日期：2020-02-12 00:00:00
abstract：BACKGROUND:The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to discover novel L-type voltag...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01801-9
更新日期：2020-04-25 00:00:00
abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0680-x
更新日期：2016-08-26 00:00:00
abstract：BACKGROUND:In meningitis, the cerebrospinal fluid contains high levels of innate immune molecules (e.g. complement) which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes (neutrophils, monocytes). However, epithelial cells of either the ependymal layer, one of the establi...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-3-22
更新日期：2006-09-02 00:00:00
abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways is a useful therapeut...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-014-0167-6
更新日期：2014-09-26 00:00:00
abstract：BACKGROUND:Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-1720-0
更新日期：2020-01-31 00:00:00
abstract：BACKGROUND:Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic hemichannels and gap junction...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1127-3
更新日期：2018-03-27 00:00:00
abstract：BACKGROUND:The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the present study, we focused on the ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-9-34
更新日期：2012-02-18 00:00:00
abstract：BACKGROUND:Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor,...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-6-14
更新日期：2009-04-28 00:00:00
abstract：BACKGROUND:Andrographolide is the major bioactive compound isolated from Andrographis paniculata, a native South Asian herb used medicinally for its anti-inflammatory properties. In this study, we aimed to assess andrographolide's potential utility as an anti-neuroinflammatory therapeutic. METHODS:The effects of andro...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0498-6
更新日期：2016-02-09 00:00:00
abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-7
更新日期：2014-01-10 00:00:00
abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-132
更新日期：2014-07-28 00:00:00
abstract：BACKGROUND:Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but are not a quickly measured serum inflammatory or neuronal biomarkers to rapidly a...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1595-0
更新日期：2019-10-28 00:00:00
abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-017-0891-9
更新日期：2017-06-06 00:00:00
abstract：BACKGROUND:Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility of the SN a...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1181-x
更新日期：2018-05-11 00:00:00
abstract：BACKGROUND:Neuroinflammation is considered a risk factor for impairments in neuronal function and cognition that arise with trauma, infection, and/or disease. IL-17A has been determined to be involved in neurodegenerative diseases such as multiple sclerosis. Recently, IL-17A has been shown to be upregulated in lipopoly...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0394-5
更新日期：2015-09-15 00:00:00
