5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.

abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

journal_title：Journal of neuroinflammation

authors： Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Persistent systemic infection results in excessive trafficking of peripheral immune cells into the central nervous system (CNS), thereby contributing to sustained neuroinflammation that leads to neurocognitive deficits. In this study, we explored the role of opportunistic systemic infection with Streptococcu...

journal_title：Journal of neuroinflammation

authors： Dutta R,Roy S

更新日期：2015-06-20 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

journal_title：Journal of neuroinflammation

authors： Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory reaction plays a crucial role in cerebral ischemia reperfusion (IR) injury. It has been shown that activated microglia long-term existed in cerebral ischemia and induced second injury. Therefore, we hypothesize that prepared phosphatidylserine (PS)-modified microbubbles (PS-MBs) comb...

journal_title：Journal of neuroinflammation

authors： Zhao R,Jiang J,Li H,Chen M,Liu R,Sun S,Ma,Liang X,Wang S

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain. However, whether it contribu...

journal_title：Journal of neuroinflammation

authors： Jing F,Zhang Y,Long T,He W,Qin G,Zhang D,Chen L,Zhou J

更新日期：2019-11-13 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles, and prominent neuroinflammation. Recently, interference with neuroinflammation as a new therapeutic approach for AD treatment gained great interest. ...

journal_title：Journal of neuroinflammation

authors： Landlinger C,Oberleitner L,Gruber P,Noiges B,Yatsyk K,Santic R,Mandler M,Staffler G

更新日期：2015-08-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of neuroinflammation

authors： Wang YW,Zhou Q,Zhang X,Qian QQ,Xu JW,Ni PF,Qian YN

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cel...

journal_title：Journal of neuroinflammation

authors： Torres L,Noel RJ Jr

更新日期：2014-03-22 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...

journal_title：Journal of neuroinflammation

authors： Huang CY,Chen YL,Li AH,Lu JC,Wang HL

更新日期：2014-01-10 00:00:00

abstract：:Nerve injury-induced chronic pain has been an urgent problem for both public health and clinical practice. While transition to chronic pain is not an inevitable consequence of nerve injuries, the susceptibility/resilience factors and mechanisms for chronic neuropathic pain after nerve injuries still remain unknown. Cu...

journal_title：Journal of neuroinflammation

authors： Ding YQ,Luo H,Qi JG

更新日期：2020-01-03 00:00:00

abstract：BACKGROUND:Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, IL-1β, and N-methyl D-aspartate receptor subunit 2B (NR2B) genes in cochlea and inferior colliculus (...

journal_title：Journal of neuroinflammation

authors： Hwang JH,Chen JC,Yang SY,Wang MF,Chan YC

更新日期：2011-04-09 00:00:00

abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...

journal_title：Journal of neuroinflammation

authors： Dong T,Zhi L,Bhayana B,Wu MX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence from stroke and inflammatory disease models suggests that adenosine s...

journal_title：Journal of neuroinflammation

authors： Farr SA,Cuzzocrea S,Esposito E,Campolo M,Niehoff ML,Doyle TM,Salvemini D

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Chu JMT,Yan T,Zhang Y,Chen Y,Chang RCC,Wong GTC

更新日期：2020-01-03 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae meningitis is a serious inflammatory disease of the central nervous system (CNS) and is associated with high morbidity and mortality rates. The inflammatory processes initiated by recognition of bacterial components contribute to apoptosis in the hippocampal dentate gyrus. Brain-deri...

journal_title：Journal of neuroinflammation

authors： Xu D,Lian D,Wu J,Liu Y,Zhu M,Sun J,He D,Li L

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

journal_title：Journal of neuroinflammation

authors： Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

更新日期：2015-04-18 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), l...

journal_title：Journal of neuroinflammation

authors： Liu X,Ma Y,Ouyang R,Zeng Z,Zhan Z,Lu H,Cui Y,Dai Z,Luo L,He C,Li H,Zong D,Chen Y

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

journal_title：Journal of neuroinflammation

authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Low testosterone and obesity are independent risk factors for dysfunction of the nervous system including neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we investigate the independent and cooperative interactions of testosterone and diet-induced obesity on metabolic, inflammator...

journal_title：Journal of neuroinflammation

authors： Jayaraman A,Lent-Schochet D,Pike CJ

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Acute inflammation induced by reactive astrocytes after cerebral ischemia/reperfusion (I/R) injury is important for protecting the resultant lesion. Our previous study demonstrated that DJ-1 is abundantly expressed in reactive astrocytes after cerebral I/R injury. Here, we show that DJ-1 negatively regulates...

journal_title：Journal of neuroinflammation

authors： Peng L,Zhou Y,Jiang N,Wang T,Zhu J,Chen Y,Li L,Zhang J,Yu S,Zhao Y

更新日期：2020-03-09 00:00:00

abstract：BACKGROUND:Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. METHODS:We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: ...

journal_title：Journal of neuroinflammation

authors： Feng Q,Li L,Li M,Wang X

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

journal_title：Journal of neuroinflammation

authors： Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and their role in inflammatory response after SCI remained unclear. This study aimed to investigate the ...

journal_title：Journal of neuroinflammation

authors： Liu Z,Yao X,Jiang W,Li W,Zhu S,Liao C,Zou L,Ding R,Chen J

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：:Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...

journal_title：Journal of neuroinflammation

authors： Doyle TM,Hutchinson MR,Braden K,Janes K,Staikopoulos V,Chen Z,Neumann WL,Spiegel S,Salvemini D

更新日期：2020-10-22 00:00:00

abstract：:Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation. Several studies suggest that harmful immune/inflammatory responses may be the most impactful consequence of aberrant CN activity in glial cell...

journal_title：Journal of neuroinflammation

authors： Furman JL,Norris CM

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:While it is clear that inbred strains of mice have variations in immunological responsiveness, the influence of genetic background following tissue damage in the central nervous system is not fully understood. A cortical explant system was employed as a model for injury to determine whether the immediate tra...

journal_title：Journal of neuroinflammation

authors： Graber DJ,Harris BT,Hickey WF

更新日期：2011-09-26 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00