当前位置： SCI文献检索 > Journal of Neuroinflammation期刊下所有文献 > Astrocytic expression of HIV-1 viral protein R in the hippocampus causes chromatolysis, synaptic loss and memory impairment.

Astrocytic expression of HIV-1 viral protein R in the hippocampus causes chromatolysis, synaptic loss and memory impairment.

Abstract：

BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cell death of cultured rat hippocampal neurons and suppresses axonal growth. Behavioral studies are limited and suggest hyperactivity in the presence of Vpr. Thus Vpr may play a role in hippocampal loss of function. The purpose of this study is to determine the ability of HIV-1 Vpr production by astrocytes in the hippocampus to cause neurological deficits and memory impairments. METHODS:We tested the performance of rats in novel object and novel location tasks after hippocampal infusion with astrocytes expressing HIV-1 Vpr. Synaptic injury and morphological changes were measured by synaptophysin immunoreactivity and Nissl staining. RESULTS:Vpr-infused rats showed impaired novel location and novel object recognition compared with control rats expressing green fluorescent protein (GFP). This impairment was correlated with a significant decrease in synaptophysin immunoreactivity in the hippocampal CA3 region, suggesting synaptic injury in HIV-1 Vpr-treated animals. In addition, Nissl staining showed morphological changes indicative of neuronal chromatolysis in the Vpr group. The Vpr-induced neuronal damage and synaptic loss suggest that neuronal dysfunction caused the spatial and recognition memory deficits found in the Vpr-infused animals. CONCLUSIONS:In this study, we demonstrate that HIV-1 Vpr produced by astrocytes in the hippocampus impairs hippocampal-dependent learning. The data suggest Vpr is a neurotoxin with the potential to cause learning impairment in HIV-1 infected individuals even under conditions of limited viral replication.

journal_name

J Neuroinflammation

journal_title

Journal of neuroinflammation

authors

Torres L,Noel RJ Jr

doi

10.1186/1742-2094-11-53

subject

Has Abstract

pub_date

2014-03-22 00:00:00

pages

53

issn

1742-2094

pii

1742-2094-11-53

journal_volume

11

pub_type

杂志文章

相关文献

Journal of Neuroinflammation文献大全
  • Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury.

    abstract：BACKGROUND:Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-02070-2

    authors： Dukay B,Walter FR,Vigh JP,Barabási B,Hajdu P,Balassa T,Migh E,Kincses A,Hoyk Z,Szögi T,Borbély E,Csoboz B,Horváth P,Fülöp L,Penke B,Vígh L,Deli MA,Sántha M,Tóth ME

    更新日期：2021-01-10 00:00:00

  • A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experi...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1514-4

    authors： Contarini G,Franceschini D,Facci L,Barbierato M,Giusti P,Zusso M

    更新日期：2019-06-20 00:00:00

  • Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model.

    abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture (EA) is a complementary alternative medicine approach, applying an electrical current to acupuncture points. In clinical and animal studies, EA ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1665-3

    authors： Cai M,Lee JH,Yang EJ

    更新日期：2019-12-13 00:00:00

  • A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma.

    abstract：BACKGROUND:Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and in...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1576-3

    authors： Krishnan A,Kocab AJ,Zacks DN,Marshak-Rothstein A,Gregory-Ksander M

    更新日期：2019-09-30 00:00:00

  • Neutrophil contribution to spinal cord injury and repair.

    abstract：:Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant importance in regulating the damage/repair balance after injury. The role of macrophages in such nervous system lesi...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/s12974-014-0150-2

    authors： Neirinckx V,Coste C,Franzen R,Gothot A,Rogister B,Wislet S

    更新日期：2014-08-28 00:00:00

  • Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes.

    abstract：BACKGROUND:Andrographolide is the major bioactive compound isolated from Andrographis paniculata, a native South Asian herb used medicinally for its anti-inflammatory properties. In this study, we aimed to assess andrographolide's potential utility as an anti-neuroinflammatory therapeutic. METHODS:The effects of andro...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0498-6

    authors： Wong SY,Tan MG,Banks WA,Wong WS,Wong PT,Lai MK

    更新日期：2016-02-09 00:00:00

  • Osteopontin and its spatiotemporal relationship with glial cells in the striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: possible involvement in phagocytosis.

    abstract：BACKGROUND:Osteopontin (OPN, SPP1) is upregulated in response to acute brain injury, and based on its immunoreactivity, two distinct forms have been identified: intracellular OPN within brain macrophages and small granular OPN, identified as OPN-coated degenerated neurites. This study investigates the spatiotemporal re...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1489-1

    authors： Riew TR,Kim S,Jin X,Kim HL,Lee JH,Lee MY

    更新日期：2019-05-14 00:00:00

  • Neuroinflammation and psychiatric illness.

    abstract：:Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/1742-2094-10-43

    authors： Najjar S,Pearlman DM,Alper K,Najjar A,Devinsky O

    更新日期：2013-04-01 00:00:00

  • Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

    abstract：BACKGROUND:Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC has projections to brain ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-4-8

    authors： Pugh PL,Vidgeon-Hart MP,Ashmeade T,Culbert AA,Seymour Z,Perren MJ,Joyce F,Bate ST,Babin A,Virley DJ,Richardson JC,Upton N,Sunter D

    更新日期：2007-02-26 00:00:00

  • Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.

    abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0390-9

    authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

    更新日期：2015-09-17 00:00:00

  • IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation.

    abstract：BACKGROUND:Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS:In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital mic...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1169-6

    authors： Cao K,Liao X,Lu J,Yao S,Wu F,Zhu X,Shi D,Wen S,Liu L,Zhou H

    更新日期：2018-05-04 00:00:00

  • Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1(G93A) mice.

    abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disorder characterized by selective motor neuron death in the spinal cord, brainstem, and motor cortex. Neuroinflammation is one of several pathological causes of degenerating motor neurons and is induced by activated microgl...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-131

    authors： Cai M,Choi SM,Song BK,Son I,Kim S,Yang EJ

    更新日期：2013-10-29 00:00:00

  • Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia.

    abstract：OBJECTIVES:Autism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and p...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-8-142

    authors： El-Ansary AK,Ben Bacha AG,Al-Ayadhi LY

    更新日期：2011-10-15 00:00:00

  • Immunological classification of gliomas based on immunogenomic profiling.

    abstract：BACKGROUND:Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking. METHODS:We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-02030-w

    authors： Feng Q,Li L,Li M,Wang X

    更新日期：2020-11-27 00:00:00

  • Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-α levels.

    abstract：BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-014-0149-8

    authors： Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

    更新日期：2014-09-03 00:00:00

  • Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.

    abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-119

    authors： Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PG

    更新日期：2013-09-26 00:00:00

  • Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage.

    abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is a neurological emergency with limited pharmacological treatment options. Inflammation is increasingly recognized as a key pathogenic contributor to brain injury in this condition. In the present study, we examined the neuroprotective effects of the immunomodulatory agent, fin...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0234-7

    authors： Xu HL,Pelligrino DA,Paisansathan C,Testai FD

    更新日期：2015-01-27 00:00:00

  • Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after stroke.

    abstract：BACKGROUND:The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pa...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0622-7

    authors： Hao XZ,Yin LK,Zhang XX,Tian JQ,Li CC,Feng XY,Jiang M,Yang YM

    更新日期：2016-06-18 00:00:00

  • CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis.

    abstract：BACKGROUND:The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of C/EBPδ durin...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0309-5

    authors： Valls Serón M,Duitman J,Geldhoff M,Engelen-Lee J,Havik SR,Brouwer MC,van de Beek D,Spek CA

    更新日期：2015-05-10 00:00:00

  • Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs.

    abstract：BACKGROUND:Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-1720-0

    authors： Grovola MR,Paleologos N,Wofford KL,Harris JP,Browne KD,Johnson V,Duda JE,Wolf JA,Cullen DK

    更新日期：2020-01-31 00:00:00

  • Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer's disease.

    abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles, and prominent neuroinflammation. Recently, interference with neuroinflammation as a new therapeutic approach for AD treatment gained great interest. ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0369-6

    authors： Landlinger C,Oberleitner L,Gruber P,Noiges B,Yatsyk K,Santic R,Mandler M,Staffler G

    更新日期：2015-08-16 00:00:00

  • The good, the bad, and the opportunities of the complement system in neurodegenerative disease.

    abstract：:The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response. In addition, some of the early components of this cascade have been clea...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/s12974-020-02024-8

    authors： Schartz ND,Tenner AJ

    更新日期：2020-11-25 00:00:00

  • Interleukin-17 impedes Schwann cell-mediated myelination.

    abstract：BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-63

    authors： Stettner M,Lohmann B,Wolffram K,Weinberger JP,Dehmel T,Hartung HP,Mausberg AK,Kieseier BC

    更新日期：2014-03-29 00:00:00

  • Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity.

    abstract：:Oral atorvastatin has prevented or reversed paralysis in the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE), and reduced development of new MS lesions in clinical trials. Besides inhibiting development of encephalitogenic T cells, atorvastatin treatment of EAE has been associated with an...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-29

    authors： Weber MS,Prod'homme T,Youssef S,Dunn SE,Steinman L,Zamvil SS

    更新日期：2014-02-06 00:00:00

  • DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

    abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0991-6

    authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

    更新日期：2017-11-07 00:00:00

  • 5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.

    abstract：BACKGROUND:The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the present study, we focused on the ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-34

    authors： Lee JH,Kim H,Woo JH,Joe EH,Jou I

    更新日期：2012-02-18 00:00:00

  • LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

    abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0879-5

    authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

    更新日期：2017-05-22 00:00:00

  • Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples.

    abstract：BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their a...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1418-3

    authors： Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G

    更新日期：2019-02-12 00:00:00

  • Association of social and cognitive impairment and biomarkers in autism spectrum disorders.

    abstract：OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-4

    authors： Alabdali A,Al-Ayadhi L,El-Ansary A

    更新日期：2014-01-08 00:00:00

  • Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome.

    abstract：BACKGROUND:Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underl...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1456-x

    authors： Yasui M,Menjyo Y,Tokizane K,Shiozawa A,Tsuda M,Inoue K,Kiyama H

    更新日期：2019-03-30 00:00:00