CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis.

abstract：BACKGROUND:Activation of inflammation pathways in the brain occurs in Alzheimer's disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute to tau protein accumulation an...

journal_title：Journal of neuroinflammation

authors： Bennett RE,Bryant A,Hu M,Robbins AB,Hopp SC,Hyman BT

更新日期：2018-11-09 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae meningitis is a serious inflammatory disease of the central nervous system (CNS) and is associated with high morbidity and mortality rates. The inflammatory processes initiated by recognition of bacterial components contribute to apoptosis in the hippocampal dentate gyrus. Brain-deri...

journal_title：Journal of neuroinflammation

authors： Xu D,Lian D,Wu J,Liu Y,Zhu M,Sun J,He D,Li L

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macrophages infiltrate the CNS dur...

journal_title：Journal of neuroinflammation

authors： DePaula-Silva AB,Gorbea C,Doty DJ,Libbey JE,Sanchez JMS,Hanak TJ,Cazalla D,Fujinami RS

更新日期：2019-07-20 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

journal_title：Journal of neuroinflammation

authors： Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Neuroinflammation is considered a risk factor for impairments in neuronal function and cognition that arise with trauma, infection, and/or disease. IL-17A has been determined to be involved in neurodegenerative diseases such as multiple sclerosis. Recently, IL-17A has been shown to be upregulated in lipopoly...

journal_title：Journal of neuroinflammation

authors： Sun J,Zhang S,Zhang X,Zhang X,Dong H,Qian Y

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:CD8+ T lymphocytes are critical mediators of neuroinflammatory diseases. Understanding the mechanisms that govern the function of this T cell population is crucial to better understanding central nervous system autoimmune disease pathology. We recently identified a novel population of highly cytotoxic c-Met-...

journal_title：Journal of neuroinflammation

authors： Benkhoucha M,Senoner I,Lalive PH

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Recently, many studies indicate that ECT affects the immune-related cells, such as microglia, astrocytes, and lymphocytes. Moreov...

journal_title：Journal of neuroinflammation

authors： Limoa E,Hashioka S,Miyaoka T,Tsuchie K,Arauchi R,Azis IA,Wake R,Hayashida M,Araki T,Furuya M,Liaury K,Tanra AJ,Horiguchi J

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully unde...

journal_title：Journal of neuroinflammation

authors： Coelho-Santos V,Gonçalves J,Fontes-Ribeiro C,Silva AP

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating pathology remains poorly characterized. OBJECTIVE:The objective of this study is to investigate whether...

journal_title：Journal of neuroinflammation

authors： Berg CT,Khorooshi R,Asgari N,Owens T

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cel...

journal_title：Journal of neuroinflammation

authors： Torres L,Noel RJ Jr

更新日期：2014-03-22 00:00:00

abstract：BACKGROUND:Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response and demonstrated that pharmacol...

journal_title：Journal of neuroinflammation

authors： Tang Y,Soroush F,Sun S,Liverani E,Langston JC,Yang Q,Kilpatrick LE,Kiani MF

更新日期：2018-11-06 00:00:00

abstract：AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies suc...

journal_title：Journal of neuroinflammation

authors： Heras-Garvin A,Refolo V,Reindl M,Wenning GK,Stefanova N

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others n...

journal_title：Journal of neuroinflammation

authors： Virgili N,Espinosa-Parrilla JF,Mancera P,Pastén-Zamorano A,Gimeno-Bayon J,Rodríguez MJ,Mahy N,Pugliese M

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model. METHODS:In both control and endotoxinemic (5 mg/kg li...

journal_title：Journal of neuroinflammation

authors： Mihaylova S,Killian A,Mayer K,Pullamsetti SS,Schermuly R,Rosengarten B

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

journal_title：Journal of neuroinflammation

authors： Montague K,Simeoli R,Valente J,Malcangio M

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Cytokines and chemokines play an important role in the neuroinflammatory response to an initial precipitating injury such as status epilepticus (SE). These signaling molecules participate in recruitment of immune cells, including brain macrophages (microglia), as well as neuroplastic changes, deterioration o...

journal_title：Journal of neuroinflammation

authors： Arisi GM,Foresti ML,Katki K,Shapiro LA

更新日期：2015-07-02 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the resistance of the CNS against infections. We studied the influence of activin A, a member of the TGF-β family with known immunoregulatory and neuroprot...

journal_title：Journal of neuroinflammation

authors： Diesselberg C,Ribes S,Seele J,Kaufmann A,Redlich S,Bunkowski S,Hanisch UK,Michel U,Nau R,Schütze S

更新日期：2018-06-07 00:00:00

abstract：:Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic pain accelerates AD pathogenesis. In this review, we provide evidence th...

journal_title：Journal of neuroinflammation

authors： Cao S,Fisher DW,Yu T,Dong H

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation ...

journal_title：Journal of neuroinflammation

authors： Davis SM,Collier LA,Winford ED,Leonardo CC,Ajmo CT Jr,Foran EA,Kopper TJ,Gensel JC,Pennypacker KR

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

journal_title：Journal of neuroinflammation

authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

journal_title：Journal of neuroinflammation

authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

journal_title：Journal of neuroinflammation

authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and in...

journal_title：Journal of neuroinflammation

authors： Krishnan A,Kocab AJ,Zacks DN,Marshak-Rothstein A,Gregory-Ksander M

更新日期：2019-09-30 00:00:00

abstract：BACKGROUND:Brain microvascular pericytes are important constituents of the neurovascular unit. These cells are physically the closest cells to the microvascular endothelial cells in brain capillaries. They significantly contribute to the induction and maintenance of the barrier functions of the blood-brain barrier. How...

journal_title：Journal of neuroinflammation

authors： Kovac A,Erickson MA,Banks WA

更新日期：2011-10-13 00:00:00

abstract：BACKGROUND:Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (...

journal_title：Journal of neuroinflammation

authors： Byrnes KR,Loane DJ,Stoica BA,Zhang J,Faden AI

更新日期：2012-02-28 00:00:00

abstract：BACKGROUND:Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interface between the brain and the peripheral internal organs. We set out to identify mechanisms compensa...

journal_title：Journal of neuroinflammation

authors： Kobrzycka A,Napora P,Pearson BL,Pierzchała-Koziec K,Szewczyk R,Wieczorek M

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inhibitor approved in th...

journal_title：Journal of neuroinflammation

authors： Gavegnano C,Haile WB,Hurwitz S,Tao S,Jiang Y,Schinazi RF,Tyor WR

更新日期：2019-09-27 00:00:00