IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation.

abstract：BACKGROUND:Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and anxiety. While neuroinflammation in the hypothalamic paraventricu...

journal_title：Journal of neuroinflammation

authors： Althammer F,Ferreira-Neto HC,Rubaharan M,Roy RK,Patel AA,Murphy A,Cox DN,Stern JE

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:It has recently become apparent that neuroinflammation may play a significant role in Parkinson's disease (PD). This is also the case in animal paradigms of the disease. The potential neuroprotective action of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 (EX-4), which is protective against...

journal_title：Journal of neuroinflammation

authors： Harkavyi A,Abuirmeileh A,Lever R,Kingsbury AE,Biggs CS,Whitton PS

更新日期：2008-05-21 00:00:00

abstract：BACKGROUND:Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apo...

journal_title：Journal of neuroinflammation

authors： Shrivastava P,Cabrera MA,Chastain LG,Boyadjieva NI,Jabbar S,Franklin T,Sarkar DK

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the centra...

journal_title：Journal of neuroinflammation

authors： Guillemot-Legris O,Masquelier J,Everard A,Cani PD,Alhouayek M,Muccioli GG

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who ha...

journal_title：Journal of neuroinflammation

authors： Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SH

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous ...

journal_title：Journal of neuroinflammation

authors： Singh N,Hopkins SJ,Hulme S,Galea JP,Hoadley M,Vail A,Hutchinson PJ,Grainger S,Rothwell NJ,King AT,Tyrrell PJ

更新日期：2014-01-03 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

journal_title：Journal of neuroinflammation

authors： Montague K,Simeoli R,Valente J,Malcangio M

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippoc...

journal_title：Journal of neuroinflammation

authors： Kelley MH,Wu WW,Lei J,McLane M,Xie H,Hart KD,Pereira L,Burd I,Maylie J

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke...

journal_title：Journal of neuroinflammation

authors： Gautier S,Ouk T,Tagzirt M,Lefebvre C,Laprais M,Pétrault O,Dupont A,Leys D,Bordet R

更新日期：2014-05-27 00:00:00

abstract：:The role of inflammation in Alzheimer's disease (AD) has been controversial since its first consideration. As with most instances of neuroinflammation, the possibility must be considered that activation of glia and cytokine networks in AD arises merely as a reaction to neurodegeneration. Active, healthy neurons produc...

journal_title：Journal of neuroinflammation

authors： Barger SW

更新日期：2005-01-11 00:00:00

abstract：BACKGROUND:Interleukin-1 beta converting enzyme (ICE, caspase 1) is a cysteine protease that processes immature pro-IL-1β into active mature IL-1β. IL-1β is a pro-inflammatory cytokine that mediates many of the physiological and behavioral responses to inflammation. Genetic deletion of ICE has previously been shown to ...

journal_title：Journal of neuroinflammation

authors： Lawson MA,McCusker RH,Kelley KW

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Activation of NADPH oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated the role of PHOX in methamphetamine (MA)-induced neurotoxic and inflammatory changes in mice. METHODS:We examined changes in mitogen-activated protein kinases (MAPKs), ...

journal_title：Journal of neuroinflammation

authors： Dang DK,Shin EJ,Nam Y,Ryoo S,Jeong JH,Jang CG,Nabeshima T,Hong JS,Kim HC

更新日期：2016-01-18 00:00:00

abstract：BACKGROUND:Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experi...

journal_title：Journal of neuroinflammation

authors： Contarini G,Franceschini D,Facci L,Barbierato M,Giusti P,Zusso M

更新日期：2019-06-20 00:00:00

abstract：BACKGROUND:The family of 14-3-3 proteins plays an important role in the regulation of cell survival and death. Here, we investigate the role of the 14-3-3 gamma (14-3-3 γ) subunit for glial responses in autoimmune demyelination. METHODS:Expression of 14-3-3 γ in glial cell culture was investigated by reverse transcrip...

journal_title：Journal of neuroinflammation

authors： Lee DH,Steinacker P,Seubert S,Turnescu T,Melms A,Manzel A,Otto M,Linker RA

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Synaptodendritic damage is a pathological hallmark of HIV-associated neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central nervous system. In this study, we aimed to determine the molecular mechanisms of Tat-induced neurite shortening, specifically the roles of miR-132,...

journal_title：Journal of neuroinflammation

authors： Rahimian P,He JJ

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely involves chronic imm...

journal_title：Journal of neuroinflammation

authors： Kim S,Hahn YK,Podhaizer EM,McLane VD,Zou S,Hauser KF,Knapp PE

更新日期：2018-10-10 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

journal_title：Journal of neuroinflammation

authors： Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta aggregations, neurofibrillary tangles, and prominent neuroinflammation. Recently, interference with neuroinflammation as a new therapeutic approach for AD treatment gained great interest. ...

journal_title：Journal of neuroinflammation

authors： Landlinger C,Oberleitner L,Gruber P,Noiges B,Yatsyk K,Santic R,Mandler M,Staffler G

更新日期：2015-08-16 00:00:00

abstract：BACKGROUND:Betaine (glycine betaine or trimethylglycine) plays important roles as an osmolyte and a methyl donor in animals. While betaine is reported to suppress expression of proinflammatory molecules and reduce oxidative stress in aged rat kidney, the effects of betaine on the central nervous system are not well kno...

journal_title：Journal of neuroinflammation

authors： Miwa M,Tsuboi M,Noguchi Y,Enokishima A,Nabeshima T,Hiramatsu M

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

journal_title：Journal of neuroinflammation

authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

更新日期：2017-06-06 00:00:00

abstract：:Although neuroinflammation has been studied extensively in animal models of cerebral ischemia, their contrasting functions are still not completely understood. A major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine CX3CL1 (fractalkine) and its receptor, CX3CR...

journal_title：Journal of neuroinflammation

authors： Briones TL,Woods J,Wadowska M

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addit...

journal_title：Journal of neuroinflammation

authors： Leardini-Tristão M,Andrade G,Garcia C,Reis PA,Lourenço M,Moreira ETS,Lima FRS,Castro-Faria-Neto HC,Tibirica E,Estato V

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...

journal_title：Journal of neuroinflammation

authors： Bahia El Idrissi N,Bosch S,Ramaglia V,Aronica E,Baas F,Troost D

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc- or...

journal_title：Journal of neuroinflammation

authors： Merckx E,Albertini G,Paterka M,Jensen C,Albrecht P,Dietrich M,Van Liefferinge J,Bentea E,Verbruggen L,Demuyser T,Deneyer L,Lewerenz J,van Loo G,De Keyser J,Sato H,Maher P,Methner A,Massie A

更新日期：2017-01-13 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation. Inflammation may be involved in the subsequent development of neurodegenerative diseases and post-injury seizures. The p75 neurot...

journal_title：Journal of neuroinflammation

authors： Lee S,Mattingly A,Lin A,Sacramento J,Mannent L,Castel MN,Canolle B,Delbary-Gossart S,Ferzaz B,Morganti JM,Rosi S,Ferguson AR,Manley GT,Bresnahan JC,Beattie MS

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad ...

journal_title：Journal of neuroinflammation

authors： Rutar M,Natoli R,Chia RX,Valter K,Provis JM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the cellular components within the...

journal_title：Journal of neuroinflammation

authors： Yoshizaki S,Tamaru T,Hara M,Kijima K,Tanaka M,Konno DJ,Matsumoto Y,Nakashima Y,Okada S

更新日期：2021-01-06 00:00:00