Abstract:
BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement components (C1qB, C4, factor B, C3/C3b, C5 and CD88) and regulators (CD55 and CD59a) in the lumbar spinal cord of hSOD1(G93A) mice during defined disease stages. METHODS:hSOD1(G93A) and wild-type mice were examined at four different ages of disease progression. mRNA and protein expression of complement components and regulators were examined using quantitative PCR, western blotting and ELISA. Localisation of complement components within lumbar spinal cord was investigated using immunohistochemistry. Statistical differences between hSOD1(G93A) and wild-type mice were analysed using a two-tailed t-test at each stage of disease progression. RESULTS:We found several early complement factors increased as disease progressed, whilst complement regulators decreased; suggesting overall increased complement activation through the classical or alternative pathways in hSOD1(G93A) mice. CD88 was also increased during disease progression, with immunolocalisation demonstrating expression on motor neurons and increasing expression on microglia surrounding the regions of motor neuron death. CONCLUSIONS:These results indicate that local complement activation and increased expression of CD88 may contribute to motor neuron death and ALS pathology in the hSOD1(G93A) mouse. Hence, reducing complement-induced inflammation could be an important therapeutic strategy to treat ALS.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PGdoi
10.1186/1742-2094-10-119subject
Has Abstractpub_date
2013-09-26 00:00:00pages
119issn
1742-2094pii
1742-2094-10-119journal_volume
10pub_type
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journal_title:Journal of neuroinflammation
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/1742-2094-9-42
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pub_type: 杂志文章
doi:10.1186/s12974-020-01870-w
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pub_type: 杂志文章
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章,评审
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更新日期:2014-08-28 00:00:00
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1186/1742-2094-8-165
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/s12974-020-02059-x
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journal_title:Journal of neuroinflammation
pub_type: 已发布勘误
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/s12974-020-01805-5
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
doi:10.1186/1742-2094-7-83
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journal_title:Journal of neuroinflammation
pub_type: 杂志文章
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