The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson's disease.

abstract：BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

journal_title：Journal of neuroinflammation

authors： Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

journal_title：Journal of neuroinflammation

authors： Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) gene delivery...

journal_title：Journal of neuroinflammation

authors： Hines-Beard J,Bond WS,Backstrom JR,Rex TS

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:In sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model. METHODS:In both control and endotoxinemic (5 mg/kg li...

journal_title：Journal of neuroinflammation

authors： Mihaylova S,Killian A,Mayer K,Pullamsetti SS,Schermuly R,Rosengarten B

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:Synaptodendritic damage is a pathological hallmark of HIV-associated neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central nervous system. In this study, we aimed to determine the molecular mechanisms of Tat-induced neurite shortening, specifically the roles of miR-132,...

journal_title：Journal of neuroinflammation

authors： Rahimian P,He JJ

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:Mural cells synthesize and deposit laminin to the basement membrane. To investigate the function of mural cell-derived laminin, we generated a mutant mouse line lacking mural cell-derived laminin (termed PKO). In a previous study, we showed that the PKO mice were grossly normal under homeostatic condition, b...

journal_title：Journal of neuroinflammation

authors： Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility of the SN a...

journal_title：Journal of neuroinflammation

authors： Kostuk EW,Cai J,Iacovitti L

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-supporting microglia environment. Our aim was to identify a dataset of intracellular m...

journal_title：Journal of neuroinflammation

authors： Neubrand VE,Forte-Lago I,Caro M,Delgado M

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instruc...

journal_title：Journal of neuroinflammation

authors： Welser JV,Halder SK,Kant R,Boroujerdi A,Milner R

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

journal_title：Journal of neuroinflammation

authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

更新日期：2018-09-19 00:00:00

abstract：:Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant importance in regulating the damage/repair balance after injury. The role of macrophages in such nervous system lesi...

journal_title：Journal of neuroinflammation

authors： Neirinckx V,Coste C,Franzen R,Gothot A,Rogister B,Wislet S

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...

journal_title：Journal of neuroinflammation

authors： Sheean RK,Weston RH,Perera ND,D'Amico A,Nutt SL,Turner BJ

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through its NK1 receptor. Incr...

journal_title：Journal of neuroinflammation

authors： Martinez AN,Ramesh G,Jacobs MB,Philipp MT

更新日期：2015-12-30 00:00:00

abstract：:Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

journal_title：Journal of neuroinflammation

authors： Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...

journal_title：Journal of neuroinflammation

authors： Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PG

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

journal_title：Journal of neuroinflammation

authors： Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation. Inflammation may be involved in the subsequent development of neurodegenerative diseases and post-injury seizures. The p75 neurot...

journal_title：Journal of neuroinflammation

authors： Lee S,Mattingly A,Lin A,Sacramento J,Mannent L,Castel MN,Canolle B,Delbary-Gossart S,Ferzaz B,Morganti JM,Rosi S,Ferguson AR,Manley GT,Bresnahan JC,Beattie MS

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Betaine (glycine betaine or trimethylglycine) plays important roles as an osmolyte and a methyl donor in animals. While betaine is reported to suppress expression of proinflammatory molecules and reduce oxidative stress in aged rat kidney, the effects of betaine on the central nervous system are not well kno...

journal_title：Journal of neuroinflammation

authors： Miwa M,Tsuboi M,Noguchi Y,Enokishima A,Nabeshima T,Hiramatsu M

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:Both dysfunctional neuropeptide signaling and immune system activation are characteristic of complex regional pain syndrome (CRPS). Unknown is whether substance P (SP) or calcitonin gene-related peptide (CGRP) support autoantibody production and, consequently, nociceptive sensitization. METHODS:These experi...

journal_title：Journal of neuroinflammation

authors： Li WW,Guo TZ,Shi X,Birklein F,Schlereth T,Kingery WS,Clark JD

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neu...

journal_title：Journal of neuroinflammation

authors： Yshii LM,Denadai-Souza A,Vasconcelos AR,Avellar MC,Scavone C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could make a significant contribution to Aβ burden in AD. Moreover, act...

journal_title：Journal of neuroinflammation

authors： Zhao J,O'Connor T,Vassar R

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which may be related to the pathophysiology of this disease. In addition to glutamate transporters, level...

journal_title：Journal of neuroinflammation

authors： Pampliega O,Domercq M,Soria FN,Villoslada P,Rodríguez-Antigüedad A,Matute C

更新日期：2011-06-03 00:00:00

abstract：:The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS). Quinolinic acid levels are elevated in experimental autoimmune encephalomyelitis rodents, the widely used animal model of MS. Our group has also found pat...

journal_title：Journal of neuroinflammation

authors： Sundaram G,Brew BJ,Jones SP,Adams S,Lim CK,Guillemin GJ

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-gamma)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of inducible nitric oxide synthase (iNOS); however, the underlying molecular mechanisms have not yet b...

journal_title：Journal of neuroinflammation

authors： Xing B,Xin T,Hunter RL,Bing G

更新日期：2008-01-18 00:00:00

abstract：BACKGROUND:There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury. METHODS:We conducted a repeated measures, case-control study, examining associations of serum levels of pro- and...

journal_title：Journal of neuroinflammation

authors： Rusiecki J,Levin LI,Wang L,Byrne C,Krishnamurthy J,Chen L,Galdzicki Z,French LM

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

journal_title：Journal of neuroinflammation

authors： Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines...

journal_title：Journal of neuroinflammation

authors： Zhang X,Zheng Z,Liu X,Shu B,Mao P,Bai B,Hu Q,Luo M,Ma X,Cui Z,Wang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...

journal_title：Journal of neuroinflammation

authors： Levesque S,Surace MJ,McDonald J,Block ML

更新日期：2011-08-24 00:00:00