Abstract：
BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 protects neurons against inflammation-induced neuronal death using co-cultures of mouse embryonic primary cortical neurons and BV2 microglial cells upon acute neuroinflammation. Moreover, the effects of DHCR24 overexpression on dendritic spine density and morphology in cultured mature mouse hippocampal neurons and on the outcome measures of ischemia-induced brain damage in vivo in mice were assessed. RESULTS:Overexpression of DHCR24 reduced the loss of neurons under inflammation elicited by LPS and IFN-γ treatment in co-cultures of mouse neurons and BV2 microglial cells but did not affect the production of neuroinflammatory mediators, total cellular cholesterol levels, or the activity of proteins linked with neuroprotective signaling. Conversely, the levels of post-synaptic cell adhesion protein neuroligin-1 were significantly increased upon the overexpression of DHCR24 in basal growth conditions. Augmentation of DHCR24 also increased the total number of dendritic spines and the proportion of mushroom spines in mature mouse hippocampal neurons. In vivo, overexpression of DHCR24 in striatum reduced the lesion size measured by MRI in a mouse model of transient focal ischemia. CONCLUSIONS:These results suggest that the augmentation of DHCR24 levels provides neuroprotection in acute stress conditions, which lead to neuronal loss in vitro and in vivo.
journal_name
J Neuroinflammationjournal_title
Journal of neuroinflammationauthors
Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen Mdoi
10.1186/s12974-017-0991-6subject
Has Abstractpub_date
2017-11-07 00:00:00pages
215issue
1issn
1742-2094pii
10.1186/s12974-017-0991-6journal_volume
14pub_type
杂志文章abstract：:Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unknown how synaptic ac...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-014-0222-3
更新日期：2015-01-09 00:00:00
abstract：:BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays a significant role in th...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-2-10
更新日期：2005-04-06 00:00:00
abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0441-2
更新日期：2015-11-24 00:00:00
abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is a neurological emergency with limited pharmacological treatment options. Inflammation is increasingly recognized as a key pathogenic contributor to brain injury in this condition. In the present study, we examined the neuroprotective effects of the immunomodulatory agent, fin...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0234-7
更新日期：2015-01-27 00:00:00
abstract：BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-11-35
更新日期：2014-02-24 00:00:00
abstract：BACKGROUND:Traumatic brain injury (TBI) is a major cause of death and disability in the USA and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill Summ 66:1-16, 2017). Contact sports athletes often experience repetitive TBI (rTBI), which exerts a cumulative effect later in life. Visual...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1499-z
更新日期：2019-05-31 00:00:00
abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-014-0154-y
更新日期：2014-09-16 00:00:00
abstract：BACKGROUND AND PURPOSE:Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neuroprotection remain elusive. ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1557-6
更新日期：2019-08-31 00:00:00
abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-10-69
更新日期：2013-06-04 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged inflammatory response via its recognition by micr...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1473-9
更新日期：2019-04-16 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc- or...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0787-0
更新日期：2017-01-13 00:00:00
abstract：:BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respon...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-1-2
更新日期：2004-04-20 00:00:00
abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1170-0
更新日期：2018-05-23 00:00:00
abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01907-0
更新日期：2020-08-10 00:00:00
abstract：BACKGROUND:Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (AS...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-014-0187-2
更新日期：2014-10-27 00:00:00
abstract：BACKGROUND:Acute traumatic brain injury (TBI) represents one of major causes of mortality and disability in the USA. Neuroinflammation has been regarded both beneficial and detrimental, probably in a time-dependent fashion. METHODS:To address a role for neuroinflammation in brain injury, C57BL/6 mice were subjected to...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0663-y
更新日期：2016-08-25 00:00:00
abstract：BACKGROUND:Activation of hyaluronic acid (HA) and associated enzyme synthesis has been demonstrated in experimental stroke animal models. Our study aimed to investigate the plasma levels of HA in acute stroke patients and the associations between HA levels and functional outcome. METHODS:This was a multicenter case-co...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,多中心研究
doi：10.1186/1742-2094-11-101
更新日期：2014-06-10 00:00:00
abstract：BACKGROUND:Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a subsequent neurotoxic dose of the drug. We have explored the mechanism...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/1742-2094-8-165
更新日期：2011-11-24 00:00:00
abstract：BACKGROUND:Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and in...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1576-3
更新日期：2019-09-30 00:00:00
abstract：:Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant importance in regulating the damage/repair balance after injury. The role of macrophages in such nervous system lesi...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章,评审
doi：10.1186/s12974-014-0150-2
更新日期：2014-08-28 00:00:00
abstract：BACKGROUND:The chemokine interleukin-8 (IL-8) and its receptor CXCR2 contribute to chemotactic responses in Alzheimer's disease (AD); however, properties of the ligand and receptor have not been characterized in animal models of disease. The primary aim of our study was to examine effects of pharmacological antagonism ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0339-z
更新日期：2015-08-09 00:00:00
abstract：BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-02062-2
更新日期：2021-01-09 00:00:00
abstract：BACKGROUND:Chorioamnionitis is associated with an increased risk of brain injury in preterm neonates. Inflammatory changes in brain could underlie this injury. Here, we evaluated whether neuroinflammation is induced by chorioamnionitis in a clinically relevant model. METHODS:Rhesus macaque fetuses were exposed to eith...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-016-0706-4
更新日期：2016-09-06 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cyclohexene-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanami...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-02022-w
更新日期：2020-11-22 00:00:00
abstract：BACKGROUND:Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer's disease (AD); however, VCID is commonly found as a co-morbidity with sporadic AD. We have previously established a mouse model of VCID by inducing hyperhomocysteinemia in both w...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1685-z
更新日期：2019-12-30 00:00:00
abstract：:Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-020-01975-2
更新日期：2020-10-22 00:00:00
abstract：BACKGROUND:The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismutase 1 (SOD1) mice, w...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0254-3
更新日期：2015-02-27 00:00:00
abstract：BACKGROUND:In brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the initial events triggered by inflammation or oxidative stress that provoke axonal damage is critical for the development of neuroprotective therapies. Energy...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-015-0375-8
更新日期：2015-08-28 00:00:00
abstract：BACKGROUND:Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the ...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-019-1653-7
更新日期：2020-01-03 00:00:00
abstract：BACKGROUND:Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unkn...
journal_title：Journal of neuroinflammation
pub_type： 杂志文章
doi：10.1186/s12974-018-1153-1
更新日期：2018-05-03 00:00:00
