Interleukin 18 in the CNS.

abstract：:Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary infla...

journal_title：Journal of neuroinflammation

authors： Wang PF,Xiong XY,Chen J,Wang YC,Duan W,Yang QW

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:Leukocytes are believed to be involved in delayed cell death following traumatic brain injury (TBI). However, data demonstrating that blood-borne inflammatory cells are present in the injured brain prior to the onset of secondary brain damage have been inconclusive. We therefore investigated both the interac...

journal_title：Journal of neuroinflammation

authors： Schwarzmaier SM,Zimmermann R,McGarry NB,Trabold R,Kim SW,Plesnila N

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory reaction in response to bacterial brain invasion. Metformin-a biguanide...

journal_title：Journal of neuroinflammation

authors： Muri L,Le ND,Zemp J,Grandgirard D,Leib SL

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration w...

journal_title：Journal of neuroinflammation

authors： Vogel DY,Heijnen PD,Breur M,de Vries HE,Tool AT,Amor S,Dijkstra CD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Chu JMT,Yan T,Zhang Y,Chen Y,Chang RCC,Wong GTC

更新日期：2020-01-03 00:00:00

abstract：BACKGROUND:Human gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their a...

journal_title：Journal of neuroinflammation

authors： Feng E,Liang T,Wang X,Du J,Tang K,Wang X,Wang F,You G

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Low testosterone and obesity are independent risk factors for dysfunction of the nervous system including neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we investigate the independent and cooperative interactions of testosterone and diet-induced obesity on metabolic, inflammator...

journal_title：Journal of neuroinflammation

authors： Jayaraman A,Lent-Schochet D,Pike CJ

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...

journal_title：Journal of neuroinflammation

authors： Mezzapesa A,Orset C,Plawinski L,Doeuvre L,Martinez de Lizarrondo S,Chimienti G,Vivien D,Mansour A,Matà S,Pepe G,Anglés-Cano E

更新日期：2014-09-16 00:00:00

abstract：:BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays a significant role in th...

journal_title：Journal of neuroinflammation

authors： Kagitani-Shimono K,Mohri I,Fujitani Y,Suzuki K,Ozono K,Urade Y,Taniike M

更新日期：2005-04-06 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible factor which may contribute is interferon-γ (IFNγ). IFNγ h...

journal_title：Journal of neuroinflammation

authors： Lyons A,Murphy KJ,Clarke R,Lynch MA

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) gene delivery...

journal_title：Journal of neuroinflammation

authors： Hines-Beard J,Bond WS,Backstrom JR,Rex TS

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallmark of Parkinson's disease (PD). The pathogenesis of this type of neurological disorders often involv...

journal_title：Journal of neuroinflammation

authors： Liu RP,Zou M,Wang JY,Zhu JJ,Lai JM,Zhou LL,Chen SF,Zhang X,Zhu JH

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still unclear if the chemokine domain of the ligand CX3CL1 is essential in regulat...

journal_title：Journal of neuroinflammation

authors： Bemiller SM,Maphis NM,Formica SV,Wilson GN,Miller CM,Xu G,Kokiko-Cochran ON,Kim KW,Jung S,Cannon JL,Crish SD,Cardona AE,Lamb BT,Bhaskar K

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behavioural models of pain; however, the potential underlying spinal neuroph...

journal_title：Journal of neuroinflammation

authors： Meesawatsom P,Burston J,Hathway G,Bennett A,Chapman V

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

journal_title：Journal of neuroinflammation

authors： Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs) mitigate DAergic neurotoxicity in rodent models of PD. ...

journal_title：Journal of neuroinflammation

authors： L'Episcopo F,Tirolo C,Caniglia S,Testa N,Serra PA,Impagnatiello F,Morale MC,Marchetti B

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways is a useful therapeut...

journal_title：Journal of neuroinflammation

authors： Jiang M,Li J,Peng Q,Liu Y,Liu W,Luo C,Peng J,Li J,Yung KK,Mo Z

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) makes a great contribution to host defense and inflammation. In many settings, lipopolysaccharide (LPS) induces iNOS expression through activation of the inhibitor of κB-α (IκB-α)-nuclear factor-κB (NF-κB) cascade, whereas interferon-γ (IFN-γ) acts through Janus kinase ...

journal_title：Journal of neuroinflammation

authors： Huang C,Lu X,Tong L,Wang J,Zhang W,Jiang B,Yang R

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture (EA) is a complementary alternative medicine approach, applying an electrical current to acupuncture points. In clinical and animal studies, EA ...

journal_title：Journal of neuroinflammation

authors： Cai M,Lee JH,Yang EJ

更新日期：2019-12-13 00:00:00

abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

journal_title：Journal of neuroinflammation

authors： Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

更新日期：2016-10-04 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate immune sensing. Its activation leads to the maturation of caspase-1 and regulates the cleavage of interleukin (IL)-1β and IL-18. Various studies have shown t...

journal_title：Journal of neuroinflammation

authors： Zhang ZT,Du XM,Ma XJ,Zong Y,Chen JK,Yu CL,Liu YG,Chen YC,Zhao LJ,Lu GC

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...

journal_title：Journal of neuroinflammation

authors： Huang CY,Chen YL,Li AH,Lu JC,Wang HL

更新日期：2014-01-10 00:00:00

abstract：BACKGROUND:A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3...

journal_title：Journal of neuroinflammation

authors： Montague K,Simeoli R,Valente J,Malcangio M

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson's disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to neurodegeneration in P...

journal_title：Journal of neuroinflammation

authors： Hou L,Qu X,Qiu X,Huang R,Zhao X,Wang Q

更新日期：2020-05-06 00:00:00

abstract：:Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...

journal_title：Journal of neuroinflammation

authors： Doyle TM,Hutchinson MR,Braden K,Janes K,Staikopoulos V,Chen Z,Neumann WL,Spiegel S,Salvemini D

更新日期：2020-10-22 00:00:00

abstract：:Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated inflammation is associated with the pathogenesis of various neuronal disorders. Recently, many studies have shown that mesenchymal stem cells (MSCs) display a remarkable ability to modulate inflammatory and immune responses through ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Zhang R,Yan K,Chen F,Huang W,Lv B,Sun C,Xu L,Li F,Jiang X

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer's disease (AD), few have explored this in FTLD. We examined regional patterns of microglial burden, activation and dystrophy ...

journal_title：Journal of neuroinflammation

authors： Woollacott IOC,Toomey CE,Strand C,Courtney R,Benson BC,Rohrer JD,Lashley T

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...

journal_title：Journal of neuroinflammation

authors： Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PG

更新日期：2013-09-26 00:00:00