Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model.

abstract：BACKGROUND:Although evidence suggests that the prevalence of Parkinson's disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying the anti-inflamma...

journal_title：Journal of neuroinflammation

authors： Liu Y,Hu J,Wu J,Zhu C,Hui Y,Han Y,Huang Z,Ellsworth K,Fan W

更新日期：2012-05-24 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...

journal_title：Journal of neuroinflammation

authors： Shi X,Chen Y,Nadeem L,Xu G

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...

journal_title：Journal of neuroinflammation

authors： Yang F,Sun W,Yang Y,Wang Y,Li CL,Fu H,Wang XL,Yang F,He T,Chen J

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others n...

journal_title：Journal of neuroinflammation

authors： Virgili N,Espinosa-Parrilla JF,Mancera P,Pastén-Zamorano A,Gimeno-Bayon J,Rodríguez MJ,Mahy N,Pugliese M

更新日期：2011-11-02 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired neurodevelopment. The mechanisms linking NEC lesions with later neurodevelopment are poorly understood but may include proinflammatory...

journal_title：Journal of neuroinflammation

authors： Sun J,Pan X,Christiansen LI,Yuan XL,Skovgaard K,Chatterton DEW,Kaalund SS,Gao F,Sangild PT,Pankratova S

更新日期：2018-06-09 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects of oligodendrocytes in neurodegenerative diseases, it remains unknown whether ol...

journal_title：Journal of neuroinflammation

authors： Yue Y,Stanojlovic M,Lin Y,Karsenty G,Lin W

更新日期：2019-02-01 00:00:00

abstract：:BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respon...

journal_title：Journal of neuroinflammation

authors： Wu SZ,Bodles AM,Porter MM,Griffin WS,Basile AS,Barger SW

更新日期：2004-04-20 00:00:00

abstract：BACKGROUND:Cranial radiotherapy is used to treat tumors of the central nervous system (CNS), as well as non-neoplastic conditions such as arterio-venous malformations; however, its use is limited by the tolerance of adjacent normal CNS tissue, which can lead to devastating long-term sequelae for patients. Despite decad...

journal_title：Journal of neuroinflammation

authors： Moravan MJ,Olschowka JA,Williams JP,O'Banion MK

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Neuroinflammation has long been considered a driver of Alzheimer's disease progression. However, experiments developed to explore the interaction between neuroinflammation and Alzheimer's disease (AD) pathology showed a surprising reduction in amyloid beta (Aβ) plaque deposition. We sought to understand this...

journal_title：Journal of neuroinflammation

authors： Cherry JD,Olschowka JA,O'Banion MK

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission o...

journal_title：Journal of neuroinflammation

authors： Yang S,Gao L,Lu F,Wang B,Gao F,Zhu G,Cai Z,Lai J,Yang Q

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturate...

journal_title：Journal of neuroinflammation

authors： Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addit...

journal_title：Journal of neuroinflammation

authors： Leardini-Tristão M,Andrade G,Garcia C,Reis PA,Lourenço M,Moreira ETS,Lima FRS,Castro-Faria-Neto HC,Tibirica E,Estato V

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Recent studies described a critical role for microglia in Parkinson's disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra. Understanding the phenotype switch of microgl...

journal_title：Journal of neuroinflammation

authors： Lu J,Dou F,Yu Z

更新日期：2019-12-26 00:00:00

abstract：INTRODUCTION:We have demonstrated previously that the intravenous delivery of multipotent adult progenitor cells (MAPC) after traumatic brain injury affords neuroprotection via interaction with splenocytes, leading to an increase in systemic anti-inflammatory cytokines. We hypothesize that the observed modulation of th...

journal_title：Journal of neuroinflammation

authors： Walker PA,Bedi SS,Shah SK,Jimenez F,Xue H,Hamilton JA,Smith P,Thomas CP,Mays RW,Pati S,Cox CS Jr

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternativ...

journal_title：Journal of neuroinflammation

authors： Xu S,Zhu W,Shao M,Zhang F,Guo J,Xu H,Jiang J,Ma X,Xia X,Zhi X,Zhou P,Lu F

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:Pharmaceutical treatment with probable anti-inflammatory substances that attack cells in various ways including receptors, ion channels, or transporter systems may slow down the progression of inflammatory conditions. Astrocytes and microglia are the most prominent target cells for inflammation in the centra...

journal_title：Journal of neuroinflammation

authors： Hansson E,Björklund U,Skiöldebrand E,Rönnbäck L

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

journal_title：Journal of neuroinflammation

authors： Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

journal_title：Journal of neuroinflammation

authors： Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes with the immunomodulatory drug fingolimod has proven effective in the treatment of multiple scleros...

journal_title：Journal of neuroinflammation

authors： Szepanowski F,Derksen A,Steiner I,Meyer Zu Hörste G,Daldrup T,Hartung HP,Kieseier BC

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

journal_title：Journal of neuroinflammation

authors： Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been performed. This study theref...

journal_title：Journal of neuroinflammation

authors： Lee JD,Levin SC,Willis EF,Li R,Woodruff TM,Noakes PG

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. with host defense mechanisms are poorly understood. This study addressed Ureaplasma-driven...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Haarmann A,Fehrholz M,Claus H,Speer CP,Glaser K

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity's cognitive effects. We have seen that, in the rat, ov...

journal_title：Journal of neuroinflammation

authors： De Luca SN,Ziko I,Sominsky L,Nguyen JC,Dinan T,Miller AA,Jenkins TA,Spencer SJ

更新日期：2016-05-18 00:00:00

abstract：BACKGROUND:Repetitive mild traumatic brain injuries (rmTBI) are associated with cognitive deficits, inflammation, and stress-related events. We tested the effect of nutrient intake on the impact of rmTBI in an animal model of chronic traumatic encephalopathy (CTE) to study the pathophysiological mechanisms underlying t...

journal_title：Journal of neuroinflammation

authors： Yu J,Zhu H,Taheri S,Mondy W,Perry S,Kindy MS

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

journal_title：Journal of neuroinflammation

authors： Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:Persistent systemic infection results in excessive trafficking of peripheral immune cells into the central nervous system (CNS), thereby contributing to sustained neuroinflammation that leads to neurocognitive deficits. In this study, we explored the role of opportunistic systemic infection with Streptococcu...

journal_title：Journal of neuroinflammation

authors： Dutta R,Roy S

更新日期：2015-06-20 00:00:00

abstract：BACKGROUND:The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS:Surface immunocytochemistry directly vis...

journal_title：Journal of neuroinflammation

authors： Lee PR,Johnson TP,Gnanapavan S,Giovannoni G,Wang T,Steiner JP,Medynets M,Vaal MJ,Gartner V,Nath A

更新日期：2017-06-27 00:00:00