Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats.

abstract：BACKGROUND:Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been associated recently with a series of neurological syndromes, including encephalitis. In this work, we ev...

journal_title：Journal of neuroinflammation

authors： Amaral DC,Rachid MA,Vilela MC,Campos RD,Ferreira GP,Rodrigues DH,Lacerda-Queiroz N,Miranda AS,Costa VV,Campos MA,Kroon EG,Teixeira MM,Teixeira AL

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-gal...

journal_title：Journal of neuroinflammation

authors： Ullah R,Jo MH,Riaz M,Alam SI,Saeed K,Ali W,Rehman IU,Ikram M,Kim MO

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission o...

journal_title：Journal of neuroinflammation

authors： Yang S,Gao L,Lu F,Wang B,Gao F,Zhu G,Cai Z,Lai J,Yang Q

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs) mitigate DAergic neurotoxicity in rodent models of PD. ...

journal_title：Journal of neuroinflammation

authors： L'Episcopo F,Tirolo C,Caniglia S,Testa N,Serra PA,Impagnatiello F,Morale MC,Marchetti B

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...

journal_title：Journal of neuroinflammation

authors： Levesque S,Surace MJ,McDonald J,Block ML

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:While it is clear that inbred strains of mice have variations in immunological responsiveness, the influence of genetic background following tissue damage in the central nervous system is not fully understood. A cortical explant system was employed as a model for injury to determine whether the immediate tra...

journal_title：Journal of neuroinflammation

authors： Graber DJ,Harris BT,Hickey WF

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS:We studied the HLA-B & C a...

journal_title：Journal of neuroinflammation

authors： Lehmann DJ,Barnardo MC,Fuggle S,Quiroga I,Sutherland A,Warden DR,Barnetson L,Horton R,Beck S,Smith AD

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Neuroinflammation is considered a risk factor for impairments in neuronal function and cognition that arise with trauma, infection, and/or disease. IL-17A has been determined to be involved in neurodegenerative diseases such as multiple sclerosis. Recently, IL-17A has been shown to be upregulated in lipopoly...

journal_title：Journal of neuroinflammation

authors： Sun J,Zhang S,Zhang X,Zhang X,Dong H,Qian Y

更新日期：2015-09-15 00:00:00

abstract：:Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

journal_title：Journal of neuroinflammation

authors： Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. Studies in the SOD1(G93A) mouse show deposition of C1q and C3/C3b at the motor en...

journal_title：Journal of neuroinflammation

authors： Bahia El Idrissi N,Bosch S,Ramaglia V,Aronica E,Baas F,Troost D

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...

journal_title：Journal of neuroinflammation

authors： Li J,Fang L,Meyer P,Killer HE,Flammer J,Neutzner A

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

journal_title：Journal of neuroinflammation

authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well understood. To help determine these pathways, we previously used micr...

journal_title：Journal of neuroinflammation

authors： Spradling KD,Lumley LA,Robison CL,Meyerhoff JL,Dillman JF 3rd

更新日期：2011-07-21 00:00:00

abstract：BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...

journal_title：Journal of neuroinflammation

authors： Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Osteopontin (OPN, SPP1) is upregulated in response to acute brain injury, and based on its immunoreactivity, two distinct forms have been identified: intracellular OPN within brain macrophages and small granular OPN, identified as OPN-coated degenerated neurites. This study investigates the spatiotemporal re...

journal_title：Journal of neuroinflammation

authors： Riew TR,Kim S,Jin X,Kim HL,Lee JH,Lee MY

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and their role in inflammatory response after SCI remained unclear. This study aimed to investigate the ...

journal_title：Journal of neuroinflammation

authors： Liu Z,Yao X,Jiang W,Li W,Zhu S,Liao C,Zou L,Ding R,Chen J

更新日期：2020-03-20 00:00:00

abstract：:Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric...

journal_title：Journal of neuroinflammation

authors： Najjar S,Pearlman DM,Alper K,Najjar A,Devinsky O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels ...

journal_title：Journal of neuroinflammation

authors： Bajnok A,Berta L,Orbán C,Veres G,Zádori D,Barta H,Méder Ü,Vécsei L,Tulassay T,Szabó M,Toldi G

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

journal_title：Journal of neuroinflammation

authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE:This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reactive oxygen species (...

journal_title：Journal of neuroinflammation

authors： Chen M,Yang LL,Hu ZW,Qin C,Zhou LQ,Duan YL,Bosco DB,Wu LJ,Zhan KB,Xu SB,Tian DS

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroinflammation after ischemic stroke; however, its effect on modulating microglial polarization is larg...

journal_title：Journal of neuroinflammation

authors： Song D,Zhang X,Chen J,Liu X,Xue J,Zhang L,Lan X

更新日期：2019-12-06 00:00:00

abstract：BACKGROUND:In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macrophages infiltrate the CNS dur...

journal_title：Journal of neuroinflammation

authors： DePaula-Silva AB,Gorbea C,Doty DJ,Libbey JE,Sanchez JMS,Hanak TJ,Cazalla D,Fujinami RS

更新日期：2019-07-20 00:00:00

abstract：BACKGROUND:Bacterial meningitis is associated with high mortality and long-term neurological sequelae. Increasing the phagocytic activity of microglia could improve the resistance of the CNS against infections. We studied the influence of activin A, a member of the TGF-β family with known immunoregulatory and neuroprot...

journal_title：Journal of neuroinflammation

authors： Diesselberg C,Ribes S,Seele J,Kaufmann A,Redlich S,Bunkowski S,Hanisch UK,Michel U,Nau R,Schütze S

更新日期：2018-06-07 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is a neurological emergency with limited pharmacological treatment options. Inflammation is increasingly recognized as a key pathogenic contributor to brain injury in this condition. In the present study, we examined the neuroprotective effects of the immunomodulatory agent, fin...

journal_title：Journal of neuroinflammation

authors： Xu HL,Pelligrino DA,Paisansathan C,Testai FD

更新日期：2015-01-27 00:00:00

abstract：:The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome is a member of the NLR family of innate immune cell sensors. These are crucial regulators of cytokine secretions, which promote ischemic cell death and insulin resistance. This review summarizes rece...

journal_title：Journal of neuroinflammation

authors： Hong P,Gu RN,Li FX,Xiong XX,Liang WB,You ZJ,Zhang HF

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer's disease. Although IL-1β-induced impairments in long-term potentiation (LTP) in acute hippocampal slices and memory functions in vivo have been well documented,...

journal_title：Journal of neuroinflammation

authors： Tong L,Prieto GA,Cotman CW

更新日期：2018-04-30 00:00:00

abstract：:Oral atorvastatin has prevented or reversed paralysis in the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE), and reduced development of new MS lesions in clinical trials. Besides inhibiting development of encephalitogenic T cells, atorvastatin treatment of EAE has been associated with an...

journal_title：Journal of neuroinflammation

authors： Weber MS,Prod'homme T,Youssef S,Dunn SE,Steinman L,Zamvil SS

更新日期：2014-02-06 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ is more toxic to OPCs ...

journal_title：Journal of neuroinflammation

authors： Horiuchi M,Itoh A,Pleasure D,Ozato K,Itoh T

更新日期：2011-01-24 00:00:00