Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases.

abstract：:Behavioral and electrophysiological studies of Alzheimer's disease (AD) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. Re...

journal_title：Frontiers in cellular neuroscience

authors： Erez H,Shemesh OA,Spira ME

更新日期：2014-02-10 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2019.00150.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Chen Q,Qiao Y,Xu XJ,You X,Tao Y

更新日期：2019-08-22 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Microglia are the resident immune cells of the brain and react quickly to changes in their environment with transcriptional regulation and morphological changes. Brain tissue injury such as ischemic stroke induces a local inflammatory response encompassing microglial activation. The change in activation status of a mi...

journal_title：Frontiers in cellular neuroscience

authors： Heindl S,Gesierich B,Benakis C,Llovera G,Duering M,Liesz A

更新日期：2018-04-19 00:00:00

abstract：:The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neuro...

journal_title：Frontiers in cellular neuroscience

authors： Atluri VS,Hidalgo M,Samikkannu T,Kurapati KR,Jayant RD,Sagar V,Nair MP

更新日期：2015-06-10 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, affecting two-thirds of people with dementia in the world. To date, no disease-modifying treatments are available to stop or delay the progression of AD. This chronic neurodegenerative disease is dominated by a strong innate immune response, whereby microgl...

journal_title：Frontiers in cellular neuroscience

authors： Martin-Estebane M,Gomez-Nicola D

更新日期：2020-06-05 00:00:00

abstract：:Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the symptoms of epilepsy without providing disease-modifying benefits. Ion...

journal_title：Frontiers in cellular neuroscience

authors： Wilson SM,Ki Yeon S,Yang XF,Park KD,Khanna R

更新日期：2014-05-28 00:00:00

abstract：:Spontaneous calcium transients are present during early postnatal development in the mouse retina and cochlea, and play an important role in maturation of the sensory organs and neural circuits in the central nervous system (CNS). It is not known whether similar calcium transients occur during postnatal development in...

journal_title：Frontiers in cellular neuroscience

authors： Holman HA,Poppi LA,Frerck M,Rabbitt RD

更新日期：2019-05-07 00:00:00

abstract：:The blood-brain barrier (BBB) is a physical and biochemical barrier that maintains cerebral homeostasis. BBB dysfunction in an ischemic stroke, results in brain injury and subsequent neurological impairment. The aim of this study was to determine the possible protective effects of 1, 25-dihydroxyvitamin D3 [1, 25(OH)2...

journal_title：Frontiers in cellular neuroscience

authors： Guo T,Wang Y,Guo Y,Wu S,Chen W,Liu N,Wang Y,Geng D

更新日期：2018-12-17 00:00:00

abstract：:Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are not well understood. Propofol (30 or 60 mg/kg) was administered to mice on pos...

journal_title：Frontiers in cellular neuroscience

authors： Xiao R,Yu D,Li X,Huang J,Jing S,Bao X,Yang T,Fan X

更新日期：2017-11-22 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal ...

journal_title：Frontiers in cellular neuroscience

authors： Mottahedin A,Ardalan M,Chumak T,Riebe I,Ek J,Mallard C

更新日期：2017-07-11 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly pleasurable experience initially associated with the consumption of the drug. We have recently found that members of the CPEB family of proteins (Cytoplasmic Polyade...

journal_title：Frontiers in cellular neuroscience

authors： Drisaldi B,Colnaghi L,Levine A,Huang Y,Snyder AM,Metzger DJ,Theis M,Kandel DB,Kandel ER,Fioriti L

更新日期：2020-07-09 00:00:00

abstract：:Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions of people worldwide. The alarming estimated rates of prevalence and relapse make it a global public health concern. Moreover, the current setback of available antidepressants in the clinical setting is discouraging. Therefor...

journal_title：Frontiers in cellular neuroscience

authors： Jo WK,Zhang Y,Emrich HM,Dietrich DE

更新日期：2015-07-10 00:00:00

abstract：:Calcium transients in thin astrocytic processes can be important in synaptic plasticity, but their mechanism is not completely understood. Clearance of synaptic glutamate leads to increase in astrocytic sodium. This can electrochemically favor the reverse mode of the Na/Ca-exchanger (NCX) and allow calcium into the ce...

journal_title：Frontiers in cellular neuroscience

authors： Brazhe AR,Verisokin AY,Verveyko DV,Postnov DE

更新日期：2018-08-14 00:00:00

abstract：:Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which account for 55% of all neurological diseases, are the leading cause of permanent disability, cognitive and motor disorders and dementia. Stroke affects the function and structure of blood-brain barrier, the loss of cerebral blood fl...

journal_title：Frontiers in cellular neuroscience

authors： Posada-Duque RA,Barreto GE,Cardona-Gomez GP

更新日期：2014-08-14 00:00:00

abstract：:Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer, and integrate into neural networks encoding spatial and contextu...

journal_title：Frontiers in cellular neuroscience

authors： Belarbi K,Rosi S

更新日期：2013-09-06 00:00:00

abstract：:The GABAB receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in a number of disorders including multiple sclerosis (MS), but its precise mechanism of action is unknown. Neuroinflammation drives the central pathology in MS and is mediated by both immunoreactive glial cells a...

journal_title：Frontiers in cellular neuroscience

authors： Crowley T,Fitzpatrick JM,Kuijper T,Cryan JF,O'Toole O,O'Leary OF,Downer EJ

更新日期：2015-07-28 00:00:00

abstract：:There is growing recognition that fast mitochondrial transport in neurons is disrupted in multiple neurological diseases and psychiatric disorders. However, a major constraint in identifying novel therapeutics based on mitochondrial transport is that the large-scale analysis of fast transport is time consuming. Here w...

journal_title：Frontiers in cellular neuroscience

authors： Miller KE,Liu XA,Puthanveettil SV

更新日期：2015-11-03 00:00:00

abstract：:Synaptic transmission and its activity-dependent modulation, known as synaptic plasticity, are fundamental processes in nervous system function. Neurons may receive thousands of synaptic contacts, but synaptic regulation may occur only at individual or discrete subsets of synapses, which may have important consequence...

journal_title：Frontiers in cellular neuroscience

authors： Lines J,Covelo A,Gómez R,Liu L,Araque A

更新日期：2017-11-23 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:The cerebral cortical tissue of murine embryo and pluripotent stem cell (PSC)-derived neurons can survive in the brain and extend axons to the spinal cord. For efficient cell integration to the corticospinal tract (CST) after transplantation, the induction or selection of cortical motor neurons is important. However, ...

journal_title：Frontiers in cellular neuroscience

authors： Sano N,Shimogawa T,Sakaguchi H,Ioroi Y,Miyawaki Y,Morizane A,Miyamoto S,Takahashi J

更新日期：2017-05-01 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:The mammalian olfactory bulb (OB) displays robust activity-dependent plasticity throughout life. Dopaminergic (DA) neurons in the glomerular layer (GL) of the OB are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (TH) expression and dopamine production, followed by a substantial...

journal_title：Frontiers in cellular neuroscience

authors： Grier BD,Belluscio L,Cheetham CE

更新日期：2016-07-15 00:00:00

abstract：Background:The functional aspects of mast cell-microglia interactions are important in neuroinflammation. Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation. However, the role of mast cells in Lipopolysaccharide (LPS)-induced microglia activation, neuroinflammat...

journal_title：Frontiers in cellular neuroscience

authors： Dong H,Wang Y,Zhang X,Zhang X,Qian Y,Ding H,Zhang S

更新日期：2019-05-03 00:00:00

abstract：:The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer's disease (AD). In the present work ...

journal_title：Frontiers in cellular neuroscience

authors： Toniolo S,Serra L,Olivito G,Marra C,Bozzali M,Cercignani M

更新日期：2018-11-20 00:00:00

abstract：:Maturation of neuronal and synaptic functions during early life is essential for the development of neuronal circuits and behaviors. In newborns synaptic transmission at excitatory synapses is primarily mediated by N-methyl-D-aspartate receptors (NMDARs), and NMDAR-mediated signaling plays an important role in synapti...

journal_title：Frontiers in cellular neuroscience

authors： Hou G,Zhang ZW

更新日期：2017-11-07 00:00:00

abstract：:Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3' untranslated region (3'UTR). Variations in length and sequence of the 3'UTR may underlie changes of post-transcriptional processing, localization, miRNA targeting and stabilit...

journal_title：Frontiers in cellular neuroscience

authors： Grassi E,Santoro R,Umbach A,Grosso A,Oliviero S,Neri F,Conti L,Ala U,Provero P,DiCunto F,Merlo GR

更新日期：2019-01-10 00:00:00

abstract：:The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity. Glial cells can produce and release neurotransmitter-like molec...

journal_title：Frontiers in cellular neuroscience

authors： Van Horn MR,Sild M,Ruthazer ES

更新日期：2013-04-23 00:00:00