NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms.

abstract：:Recent research has revealed that uncontrolled chronic neuroinflammation is closely associated with diverse neurodegenerative diseases, by impairing blood-brain barrier (BBB) function and astrocytic reaction. Endoplasmic reticulum (ER) stress is conventionally linked to the loss of neuronal structure and function and ...

journal_title：Frontiers in cellular neuroscience

authors： Wang Y,Chen Y,Zhou Q,Xu J,Qian Q,Ni P,Qian Y

更新日期：2018-07-27 00:00:00

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:Outer Hair Cells (OHCs) in the mammalian cochlea display a unique type of voltage-induced mechanical movement termed electromotility, which amplifies auditory signals and contributes to the sensitivity and frequency selectivity of mammalian hearing. Electromotility occurs in the OHC lateral wall, but it is not fully u...

journal_title：Frontiers in cellular neuroscience

authors： Triffo WJ,Palsdottir H,Song J,Morgan DG,McDonald KL,Auer M,Raphael RM

更新日期：2019-12-20 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Neuroinflammation, characterized by chronic activation of the myeloid-derived microglia, is a hallmark of Alzheimer's disease (AD). Systemic inflammation, typically resulting from infection, has been linked to the progression of AD due to exacerbation of the chronic microglial reaction. However, the mechanism and the ...

journal_title：Frontiers in cellular neuroscience

authors： Thygesen C,Ilkjær L,Kempf SJ,Hemdrup AL,von Linstow CU,Babcock AA,Darvesh S,Larsen MR,Finsen B

更新日期：2018-11-06 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination itself. In this mini-review article, we summarize some of those obse...

journal_title：Frontiers in cellular neuroscience

authors： Bouçanova F,Chrast R

更新日期：2020-05-29 00:00:00

abstract：:Objective: DL-3n-butylphthalide (NBP) has beneficial effects in different stages of ischemic stroke. Our previous studies have demonstrated that NBP promoted angiogenesis in the perifocal region of the ischemic brain. However, the molecular mechanism of NBP for blood-brain barrier protection in acute ischemic stroke w...

journal_title：Frontiers in cellular neuroscience

authors： Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY

更新日期：2021-01-12 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding of SCI has certainly increased during the last decade, but remains far from clear. SCI consists ...

journal_title：Frontiers in cellular neuroscience

authors： Anwar MA,Al Shehabi TS,Eid AH

更新日期：2016-04-13 00:00:00

abstract：:Meningioma expressed antigen 6 (MEA6), also called cutaneous T cell lymphoma-associated antigen 5 (cTAGE5), was initially found in tumor tissues. MEA6 is located in endoplasmic reticulum (ER) exit sites and regulates the transport of collagen, very low density lipoprotein, and insulin. It is also reported that MEA6 mi...

journal_title：Frontiers in cellular neuroscience

authors： Wang XT,Cai XY,Xu FX,Zhou L,Zheng R,Ma KY,Xu ZH,Shen Y

更新日期：2019-06-11 00:00:00

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:The axon provides a sole output of the neuron which propagates action potentials reliably to the axon terminal and transmits neuronal information to the postsynaptic neuron across the synapse. A classical view of neuronal signaling is based on these two processes, namely binary (all or none) signaling along the axon a...

journal_title：Frontiers in cellular neuroscience

authors： Kamiya H

更新日期：2019-09-06 00:00:00

abstract：:In this review, we discuss molecular and cellular mechanisms important for the function of neuronal progenitors during development, revealed by their perturbation in different cortical malformations. We focus on a class of neuronal progenitors, radial glial cells (RGCs), which are renowned for their unique morphologic...

journal_title：Frontiers in cellular neuroscience

authors： Bizzotto S,Francis F

更新日期：2015-02-12 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Accumulation of proteins in aberrant conformation occurs in many neurodegenerative diseases. Furthermore, dysfunctions in protein handling in endoplasmic reticulum (ER) and the following ER stress have been implicated in a vast number of diseases, such as amyotrophic lateral sclerosis (ALS). During excessive ER stress...

journal_title：Frontiers in cellular neuroscience

authors： Jaronen M,Goldsteins G,Koistinaho J

更新日期：2014-12-02 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expressed in the CA2 region...

journal_title：Frontiers in cellular neuroscience

authors： Hayani H,Song I,Dityatev A

更新日期：2018-05-30 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, affecting two-thirds of people with dementia in the world. To date, no disease-modifying treatments are available to stop or delay the progression of AD. This chronic neurodegenerative disease is dominated by a strong innate immune response, whereby microgl...

journal_title：Frontiers in cellular neuroscience

authors： Martin-Estebane M,Gomez-Nicola D

更新日期：2020-06-05 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:Neurons typically receive synaptic input in their dendritic arbor, integrate inputs in their soma, and send output action potentials through their axon, following Cajal's law of dynamic polarization. Two notable exceptions are retinal amacrine cells and olfactory granule cells (GCs), which flout Cajal's edict by provi...

journal_title：Frontiers in cellular neuroscience

authors： Egger V,Diamond JS

更新日期：2020-11-05 00:00:00

abstract：:There is evidence for both neurotoxic and neuroprotective roles of nitric oxide (NO) in the brain and changes in the expression of the neuronal isoform of NO synthase (nNOS) gene occur during aging. The current studies have investigated potential support for either a neurotoxic or neuroprotective role of NO derived fr...

journal_title：Frontiers in cellular neuroscience

authors： James BM,Li Q,Luo L,Kendrick KM

更新日期：2015-03-27 00:00:00

abstract：:Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and e...

journal_title：Frontiers in cellular neuroscience

authors： Gelderblom M,Arunachalam P,Magnus T

更新日期：2014-11-05 00:00:00

abstract：:Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of which are in turn ...

journal_title：Frontiers in cellular neuroscience

authors： Verstraelen P,Detrez JR,Verschuuren M,Kuijlaars J,Nuydens R,Timmermans JP,De Vos WH

更新日期：2017-06-22 00:00:00

abstract：:Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the key active regions of sAPPα is the central APP domain (E2) that conta...

journal_title：Frontiers in cellular neuroscience

authors： Morrissey JA,Bigus E,Necarsulmer JC,Srinivasan V,Peppercorn K,O'Leary DJ,Mockett BG,Tate WP,Hughes SM,Parfitt KD,Abraham WC

更新日期：2019-10-18 00:00:00

abstract：:Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during developm...

journal_title：Frontiers in cellular neuroscience

authors： Coppi E,Cellai L,Maraula G,Dettori I,Melani A,Pugliese AM,Pedata F

更新日期：2015-04-24 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals. However, the mechanism underlying these protective effects remains unclear. We aimed to assess the effects ...

journal_title：Frontiers in cellular neuroscience

authors： Zhu W,Zhu J,Zhao S,Li J,Hou D,Zhang Y,Sun H

更新日期：2020-10-06 00:00:00