Inflammogenesis of Secondary Spinal Cord Injury.

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:To understand the potential role of enhanced hippocampal neurogenesis after pilocarpine-induced status epilepticus (SE) in the development of epilepsy, we quantitatively analyzed the geometry of apical dendrites, synaptic transmission, and activation levels of normotopically distributed mature newborn granule cells in...

journal_title：Frontiers in cellular neuroscience

authors： Gao F,Song X,Zhu D,Wang X,Hao A,Nadler JV,Zhan RZ

更新日期：2015-10-07 00:00:00

abstract：:Gamma aminobutric acid (GABA) is the major inhibitory neurotransmitter in the adult brain and mechanisms of GABAergic inhibition have been intensely investigated in the past decades. Recent studies provided evidence for an important role of astrocytes in shaping GABAergic currents. One of the most obvious, but yet poo...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor P,Rakus D,Mozrzymas JW

更新日期：2015-04-09 00:00:00

abstract：:Sensory perception is fundamental to everyday life, yet understanding of human sensory physiology at the molecular level is hindered due to constraints on tissue availability. Emerging strategies to study and characterize peripheral neuropathies in vitro involve the use of human pluripotent stem cells (hPSCs) differen...

journal_title：Frontiers in cellular neuroscience

authors： Hulme AJ,McArthur JR,Maksour S,Miellet S,Ooi L,Adams DJ,Finol-Urdaneta RK,Dottori M

更新日期：2020-12-04 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an important factor. The physical substrate for the regulation of the transc...

journal_title：Frontiers in cellular neuroscience

authors： Lazo-Gómez R,Ramírez-Jarquín UN,Tovar-Y-Romo LB,Tapia R

更新日期：2013-12-05 00:00:00

abstract：:In recent years several evidence demonstrated that some features of hippocampal biology, like neurogenesis, synaptic transmission, learning, and memory performances are deeply modulated by social, motor, and sensorial experiences. Fractalkine/CX(3)CL1 is a transmembrane chemokine abundantly expressed in the brain by n...

journal_title：Frontiers in cellular neuroscience

authors： Maggi L,Scianni M,Branchi I,D'Andrea I,Lauro C,Limatola C

更新日期：2011-10-19 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet. Therefore, responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the GLP-1 analog Exendin-4 and elucidation of molecular pathways acting downstre...

journal_title：Frontiers in cellular neuroscience

authors： Farkas I,Vastagh C,Farkas E,Bálint F,Skrapits K,Hrabovszky E,Fekete C,Liposits Z

更新日期：2016-09-12 00:00:00

abstract：:Rac1 is a major player of the Rho family of small GTPases that controls multiple cell signaling pathways, such as the organization of cytoskeleton (including adhesion and motility), cell proliferation, apoptosis and activation of immune cells. In the nervous system, in particular, Rac1 GTPase plays a key regulatory fu...

journal_title：Frontiers in cellular neuroscience

authors： D'Ambrosi N,Rossi S,Gerbino V,Cozzolino M

更新日期：2014-09-08 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:After an ischemic stroke, neural precursor cells (NPCs) proliferate within major germinal niches of the brain. Endogenous NPCs subsequently migrate toward the ischemic lesion where they promote tissue remodeling and neural repair. Unfortunately, this restorative process is generally insufficient and thus unable to sup...

journal_title：Frontiers in cellular neuroscience

authors： Hermann DM,Peruzzotti-Jametti L,Schlechter J,Bernstock JD,Doeppner TR,Pluchino S

更新日期：2014-09-16 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2017.00013.]. ...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2019-07-09 00:00:00

abstract：:The phase of firing of hippocampal neurons during theta oscillations encodes spatial information. Moreover, the spike phase response to synaptic inputs in individual cells depends on the expression of the hyperpolarization-activated mixed cation current (I h ), which differs between CA3 and CA1 pyramidal neurons. Here...

journal_title：Frontiers in cellular neuroscience

authors： Borel M,Guadagna S,Jang HJ,Kwag J,Paulsen O

更新日期：2013-12-25 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:It is well established that microglial form and function are inextricably linked. In recent years, the traditional view that microglial form ranges between "ramified resting" and "activated amoeboid" has been emphasized through advancing imaging techniques that point to microglial form being highly dynamic even within...

journal_title：Frontiers in cellular neuroscience

authors： Karperien A,Ahammer H,Jelinek HF

更新日期：2013-01-30 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT/mechani...

journal_title：Frontiers in cellular neuroscience

authors： Mecca C,Giambanco I,Bruscoli S,Bereshchenko O,Fioretti B,Riccardi C,Donato R,Arcuri C

更新日期：2018-04-10 00:00:00

abstract：:The mammalian olfactory bulb (OB) displays robust activity-dependent plasticity throughout life. Dopaminergic (DA) neurons in the glomerular layer (GL) of the OB are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (TH) expression and dopamine production, followed by a substantial...

journal_title：Frontiers in cellular neuroscience

authors： Grier BD,Belluscio L,Cheetham CE

更新日期：2016-07-15 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:Neurons typically receive synaptic input in their dendritic arbor, integrate inputs in their soma, and send output action potentials through their axon, following Cajal's law of dynamic polarization. Two notable exceptions are retinal amacrine cells and olfactory granule cells (GCs), which flout Cajal's edict by provi...

journal_title：Frontiers in cellular neuroscience

authors： Egger V,Diamond JS

更新日期：2020-11-05 00:00:00

abstract：:Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are believed to represent the different outcomes of a common pathogenic mechanism. However, while researchers have intensely studied the involvement of motor neurons in the ALS/FTD syndrome, very little is known about the function of hippocampal neu...

journal_title：Frontiers in cellular neuroscience

authors： Radzicki D,Liu E,Deng HX,Siddique T,Martina M

更新日期：2016-09-20 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs that might discriminate b...

journal_title：Frontiers in cellular neuroscience

authors： Osorio-Barrios F,Prado C,Contreras F,Pacheco R

更新日期：2018-07-10 00:00:00

abstract：:Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA therapy has become one of the highest priorities in the stroke field. This mini review article focuse...

journal_title：Frontiers in cellular neuroscience

authors： Jiang Y,Fan X,Yu Z,Liao Z,Wang XS,van Leyen K,Sun X,Lo EH,Wang X

更新日期：2015-10-14 00:00:00

abstract：:In recent years, P2X receptors have attracted increasing attention as regulators of exocytosis and cellular secretion. In various cell types, P2X receptors have been found to stimulate vesicle exocytosis directly via Ca(2+) influx and elevation of the intracellular Ca(2+) concentration. Recently, a new role for P2X4 r...

journal_title：Frontiers in cellular neuroscience

authors： Miklavc P,Thompson KE,Frick M

更新日期：2013-10-08 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:Current research indicates that the causes of autism spectrum disorders (ASDs) are multifactorial and include both genetic and environmental factors. To date, several works have associated ASDs with mutations in genes that encode proteins involved in neuronal synapses; however other factors and the way they can intera...

journal_title：Frontiers in cellular neuroscience

authors： Gámez-Del-Estal MM,Contreras I,Prieto-Pérez R,Ruiz-Rubio M

更新日期：2014-03-04 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2019.00150.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Chen Q,Qiao Y,Xu XJ,You X,Tao Y

更新日期：2019-08-22 00:00:00

abstract：:The second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) transduce many neuromodulatory signals from hormones and neurotransmitters into specific functional outputs. Their production, degradation and signaling are spatiotemporally regulated to achieve high specificity in si...

journal_title：Frontiers in cellular neuroscience

authors： Gorshkov K,Zhang J

更新日期：2014-12-04 00:00:00

abstract：:Neurons receive thousands of synaptic inputs that are distributed in space and time. The systematic study of how neurons process these inputs requires a technique to stimulate multiple yet highly targeted points of interest along the neuron's dendritic tree. Three-dimensional multi-focal patterns produced via holograp...

journal_title：Frontiers in cellular neuroscience

authors： Go MA,To MS,Stricker C,Redman S,Bachor HA,Stuart GJ,Daria VR

更新日期：2013-12-02 00:00:00

abstract：:The hippocampal mossy fibers (MFs), the axons of the granule cells (GCs) of the dentate gyrus, innervate mossy cells and interneurons in the hilus on their way to CA3 where they innervate interneurons and pyramidal cells. Synapses on each target cell have distinct anatomical and functional characteristics. In recent y...

journal_title：Frontiers in cellular neuroscience

authors： Münster-Wandowski A,Gómez-Lira G,Gutiérrez R

更新日期：2013-11-22 00:00:00