Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis.

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery. Key steps to the creation of a permissive environment for axonal regrowth are the tra...

journal_title：Frontiers in cellular neuroscience

authors： Pellegatta M,Taveggia C

更新日期：2019-03-20 00:00:00

abstract：:Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes. However, mild strokes have a better prospect for functional recovery. Recently, anatomic and behavioral changes have been reported for distal...

journal_title：Frontiers in cellular neuroscience

authors： Minassian A,Green C,Diedenhofen M,Vogel S,Hess S,Stoeber M,Radmilovic MD,Wiedermann D,Kloppenburg P,Hoehn M

更新日期：2020-04-07 00:00:00

abstract：:Brain injuries of different etiologies lead to irreversible neuronal loss and persisting neuronal deficits. New therapeutic strategies are emerging to compensate neuronal damage upon brain injury. Some of these strategies focus on enhancing endogenous generation of neurons from neural stem cells (NSCs) to substitute t...

journal_title：Frontiers in cellular neuroscience

authors： García-Bernal F,Geribaldi-Doldán N,Domínguez-García S,Carrasco M,Murillo-Carretero M,Delgado-Ariza A,Díez-Salguero M,Verástegui C,Castro C

更新日期：2018-11-27 00:00:00

abstract：:Increased expression of S100B and its specific receptor for advanced glycation end products (RAGE) has been described in patients with multiple sclerosis (MS), being associated with an active demyelinating process. We previously showed that a direct neutralization of S100B reduces lysophosphatidylcholine (LPC)-induced...

journal_title：Frontiers in cellular neuroscience

authors： Santos G,Barateiro A,Brites D,Fernandes A

更新日期：2020-09-04 00:00:00

abstract：:The postnatal development of cerebellar climbing fiber (CF) to Purkinje neuron (PN) synapses is characterized by a substantial pruning during the first 3 weeks after birth, switching from multiple- to single-CF innervation. Previous studies suggested that CF maturation is governed by bidirectional changes of synaptic ...

journal_title：Frontiers in cellular neuroscience

authors： Pätz C,Brachtendorf S,Eilers J

更新日期：2019-05-01 00:00:00

abstract：:The adult hypothalamus regulates many physiological functions and homeostatic loops, including growth, feeding and reproduction. In mammals, the hypothalamus derives from the ventral diencephalon where two distinct ventricular proliferative zones have been described. Although a set of transcription factors regulating ...

journal_title：Frontiers in cellular neuroscience

authors： Maggi R,Zasso J,Conti L

更新日期：2015-01-06 00:00:00

abstract：:Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse popula...

journal_title：Frontiers in cellular neuroscience

authors： Ernst C,Morton CC

更新日期：2013-10-02 00:00:00

abstract：:The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1's rol...

journal_title：Frontiers in cellular neuroscience

authors： Ng F,Wijaya L,Tang BL

更新日期：2015-03-09 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of NO depend on its local concentrations, as well as its availability and the nature of downstream t...

journal_title：Frontiers in cellular neuroscience

authors： Yuste JE,Tarragon E,Campuzano CM,Ros-Bernal F

更新日期：2015-08-17 00:00:00

abstract：:Nonlinear dendritic integration is thought to increase the computational ability of neurons. Most studies focus on how supralinear summation of excitatory synaptic responses arising from clustered inputs within single dendrites result in the enhancement of neuronal firing, enabling simple computations such as feature ...

journal_title：Frontiers in cellular neuroscience

authors： Tran-Van-Minh A,Cazé RD,Abrahamsson T,Cathala L,Gutkin BS,DiGregorio DA

更新日期：2015-03-24 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Nitric oxide exerts important regulatory functions in various brain processes. Its synthesis in neurons has been most commonly ascribed to the neuronal nitric oxide synthase (nNOS) isoform. However, the endothelial isoform (eNOS), which is significantly associated with caveolae in different cell types, has been implic...

journal_title：Frontiers in cellular neuroscience

authors： Caviedes A,Varas-Godoy M,Lafourcade C,Sandoval S,Bravo-Alegria J,Kaehne T,Massmann A,Figueroa JP,Nualart F,Wyneken U

更新日期：2017-07-04 00:00:00

abstract：:Synaptic transmission and its activity-dependent modulation, known as synaptic plasticity, are fundamental processes in nervous system function. Neurons may receive thousands of synaptic contacts, but synaptic regulation may occur only at individual or discrete subsets of synapses, which may have important consequence...

journal_title：Frontiers in cellular neuroscience

authors： Lines J,Covelo A,Gómez R,Liu L,Araque A

更新日期：2017-11-23 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) result from striatal dopamine (DA) deficiency due to a progressive degeneration of nigral dopaminergic cells. Although DA replacement therapy is the mainstay to treat parkinsonian symptoms, a long-term daily administration of levodopa often develops levodopa-induced dyski...

journal_title：Frontiers in cellular neuroscience

authors： Goto S

更新日期：2017-11-21 00:00:00

abstract：:Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such as dendrites, axons and somas, in th...

journal_title：Frontiers in cellular neuroscience

authors： Tominaga Y,Taketoshi M,Tominaga T

更新日期：2018-10-24 00:00:00

abstract：:Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during developm...

journal_title：Frontiers in cellular neuroscience

authors： Coppi E,Cellai L,Maraula G,Dettori I,Melani A,Pugliese AM,Pedata F

更新日期：2015-04-24 00:00:00

abstract：:The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived cells contribute to...

journal_title：Frontiers in cellular neuroscience

authors： Capilla-Gonzalez V,Cebrian-Silla A,Guerrero-Cazares H,Garcia-Verdugo JM,Quiñones-Hinojosa A

更新日期：2013-09-11 00:00:00

abstract：:Axon growth inhibitors generated by reactive glial scars play an important role in failure of axon regeneration after CNS injury in mature mammals. Among the inhibitory factors, chondroitin sulfate proteoglycans (CSPGs) are potent suppressors of axon regeneration and are important molecular targets for designing effec...

journal_title：Frontiers in cellular neuroscience

authors： Sami A,Selzer ME,Li S

更新日期：2020-07-02 00:00:00

abstract：:Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression. These effects have been linked to glial cell activation, glutamate release and changes in neuronal plasticity and survival including atrophy of hippoc...

journal_title：Frontiers in cellular neuroscience

authors： Orellana JA,Moraga-Amaro R,Díaz-Galarce R,Rojas S,Maturana CJ,Stehberg J,Sáez JC

更新日期：2015-04-02 00:00:00

abstract：:Spatially localized proteolysis represents an elegant means by which neuronal activity dependent changes in synaptic structure, and thus experience dependent learning and memory, can be achieved. In vitro and in vivo studies suggest that matrix metalloproteinase and adamalysin activity is concentrated at the cell surf...

journal_title：Frontiers in cellular neuroscience

authors： Conant K,Allen M,Lim ST

更新日期：2015-08-11 00:00:00

abstract：:Glaucoma is a multifactorial disease and especially mechanisms occurring independently from an elevated intraocular pressure (IOP) are still unknown. Likely, the immune system contributes to the glaucoma pathogenesis. Previously, IgG antibody depositions and retinal ganglion cell (RGC) loss were found in an IOP-indepe...

journal_title：Frontiers in cellular neuroscience

authors： Reinehr S,Reinhard J,Gandej M,Kuehn S,Noristani R,Faissner A,Dick HB,Joachim SC

更新日期：2016-06-01 00:00:00

abstract：:Recent advances in single-cell technologies are paving the way to a comprehensive understanding of the cellular complexity in the brain. Protocols for single-cell transcriptomics combine a variety of sophisticated methods for the purpose of isolating the heavily interconnected and heterogeneous neuronal cell types in ...

journal_title：Frontiers in cellular neuroscience

authors： Ho H,Both M,Siniard A,Sharma S,Notwell JH,Wallace M,Leone DP,Nguyen A,Zhao E,Lee H,Zwilling D,Thompson KR,Braithwaite SP,Huentelman M,Portmann T

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local...

journal_title：Frontiers in cellular neuroscience

authors： Skardelly M,Gaber K,Burdack S,Scheidt F,Schuhmann MU,Hilbig H,Meixensberger J,Boltze J

更新日期：2014-10-14 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00

abstract：:Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

journal_title：Frontiers in cellular neuroscience

authors： Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

更新日期：2019-04-24 00:00:00

abstract：:The early auditory pathway processes information at high rates and with utmost temporal fidelity. Consequently, the synapses in the auditory pathway are highly specialized to meet the extraordinary requirements on signal transmission. The calyceal synapses in the auditory brainstem feature more than a hundred active z...

journal_title：Frontiers in cellular neuroscience

authors： Huang CH,Moser T

更新日期：2018-10-17 00:00:00

abstract：:Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes mortality and long-term neurological impairments. Our previous study demonstrated activation of CD11b+ myeloid cells, including residential microglial cells (MGs) and infiltrating monocyte-derived macrophages (MDMs) in a murine mo...

journal_title：Frontiers in cellular neuroscience

authors： Min Y,Yan L,Wang Q,Wang F,Hua H,Yuan Y,Jin H,Zhang M,Zhao Y,Yang J,Jiang X,Yang Y,Li F

更新日期：2020-08-10 00:00:00

abstract：:Ion channel receptors are a vital component of nervous system signaling, allowing rapid and direct conversion of a chemical neurotransmitter message to an electrical current. In recent decades, it has become apparent that ionotropic receptors are regulated by protein-protein interactions with other ion channels, G-pro...

journal_title：Frontiers in cellular neuroscience

authors： Li S,Wong AH,Liu F

更新日期：2014-05-09 00:00:00