Abstract:
:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it remains poorly understood whether and how NAFLD affects the outcome of hemorrhagic brain injury. Here, we examined the effects of diet-induce NAFLD on ICH injury and neuroinflammation in mice. Methods: NAFLD was induced in C57BL/6 mice by feeding with a methionine-choline deficient (MCD) diet for 4 weeks. Collagenase and autologous blood models were used to evaluate the effects of NAFLD on ICH injury and neuroinflammation. Results: MCD diet for 4 weeks induces NAFLD and hyperlipidemia in mice. Mice receiving the MCD diet have aggravated neurological deficits and brain edema after ICH. The augmentation of ICH injury was accompanied by brain infiltration of neutrophils and monocytes and increased production of pro-inflammatory factors. Before ICH, MCD diet-induced mobilization of neutrophils and monocytes in the periphery. Notably, the detrimental effects of NAFLD on ICH injury was ablated in mice receiving antibody depletion of neutrophils and monocytes. Conclusions: These results suggest that NAFLD exacerbates neuroinflammation and ICH injury.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Li X,Cheng X,Wang X,Liu Q,Ma H,Li Mdoi
10.3389/fncel.2020.00154subject
Has Abstractpub_date
2020-06-08 00:00:00pages
154issn
1662-5102journal_volume
14pub_type
杂志文章abstract::Neuron-glia interactions contribute to tissue homeostasis and functional plasticity in the mammalian brain, but it remains unclear how this is achieved. The potential of central auditory brain tissue for stimulation-dependent cellular remodeling was studied in hearing-experienced and neonatally deafened rats. At adult...
journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2018.00043
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abstract::The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711-729). Four main currents were shown to be involved, namely a persistent sodium current (I(Na-p)), an h current (I(h)), an SK-type calcium-dependent potassium current (I(K-AHP)), and a slow M-like potassium cur...
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abstract::The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disord...
journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
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abstract::Prenatal immune challenge has been associated with alteration in brain development and plasticity that last into adulthood. We have previously shown that prenatal activation of toll-like receptor 4 by lipopolysaccharide (LPS) induces IL-6-dependent STAT-3 signaling pathway in the fetal brain. Whether this IL-6-depende...
journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
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abstract::Dyneins are a small class of molecular motors that bind to microtubules and walk toward their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements. In addition dyneins generate forces on microtubule arrays that power the beating of cilia and fla...
journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2014.00146
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journal_title:Frontiers in cellular neuroscience
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abstract::Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is primarily localized in the nucleus and is involved in cellular processes s...
journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fncel.2014.00231
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fncel.2016.00129
更新日期:2016-05-13 00:00:00
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2013.00091
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2020.581907
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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abstract::To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...
journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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