Rac1 Impairs Forgetting-Induced Cellular Plasticity in Mushroom Body Output Neurons.

abstract：:Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3' untranslated region (3'UTR). Variations in length and sequence of the 3'UTR may underlie changes of post-transcriptional processing, localization, miRNA targeting and stabilit...

journal_title：Frontiers in cellular neuroscience

authors： Grassi E,Santoro R,Umbach A,Grosso A,Oliviero S,Neri F,Conti L,Ala U,Provero P,DiCunto F,Merlo GR

更新日期：2019-01-10 00:00:00

abstract：:Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is still unclear. Based on our previous clinical stu...

journal_title：Frontiers in cellular neuroscience

authors： Yu S,Yu M,Bu Z,He P,Feng J

更新日期：2020-07-15 00:00:00

abstract：:Early odor preference learning in rodents occurs within a sensitive period [≤postnatal day (P)10-12], during which pups show a heightened ability to form an odor preference when a novel odor is paired with a tactile stimulation (e.g., stroking). Norepinephrine (NE) release from the locus coeruleus during stroking medi...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh A,Purchase NC,Chen X,Yuan Q

更新日期：2015-11-19 00:00:00

abstract：:An experience-driven increase in oligodendrocytes and myelin in the somatosensory cortex (S1) has emerged as a new marker of adult cortical plasticity. That finding contrasts with the view that myelin is a structural brake on plasticity, and that contributes to ending the critical period (CP) in the visual cortex (V1)...

journal_title：Frontiers in cellular neuroscience

authors： Murphy KM,Mancini SJ,Clayworth KV,Arbabi K,Beshara S

更新日期：2020-03-17 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is primarily localized in the nucleus and is involved in cellular processes s...

journal_title：Frontiers in cellular neuroscience

authors： Higelin J,Demestre M,Putz S,Delling JP,Jacob C,Lutz AK,Bausinger J,Huber AK,Klingenstein M,Barbi G,Speit G,Huebers A,Weishaupt JH,Hermann A,Liebau S,Ludolph AC,Boeckers TM

更新日期：2016-12-26 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:In vitro approaches have suggested that neuropsin (or kallikrein 8/KLK8), which controls gamma-aminobutyric acid (GABA) neurotransmission through neuregulin-1 (NRG-1) and its receptor (ErbB4), is involved in neural plasticity (Tamura et al., 2012, 2013). In the present study, we examined whether parvalbumin (PV)-posit...

journal_title：Frontiers in cellular neuroscience

authors： Suzuki H,Kanagawa D,Nakazawa H,Tawara-Hirata Y,Kogure Y,Shimizu-Okabe C,Takayama C,Ishikawa Y,Shiosaka S

更新日期：2014-12-10 00:00:00

abstract：:Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer's disease (AD), continually fail clinical trials. We investigated whether this was due to the change in the e...

journal_title：Frontiers in cellular neuroscience

authors： Petrache AL,Khan AA,Nicholson MW,Monaco A,Kuta-Siejkowska M,Haider S,Hilton S,Jovanovic JN,Ali AB

更新日期：2020-11-11 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding of SCI has certainly increased during the last decade, but remains far from clear. SCI consists ...

journal_title：Frontiers in cellular neuroscience

authors： Anwar MA,Al Shehabi TS,Eid AH

更新日期：2016-04-13 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Stem cell research depends on extensive in vitro research. Poly-D-lysine (PDL) and polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although, PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its conc...

journal_title：Frontiers in cellular neuroscience

authors： Sanchez-Mendoza EH,Schlechter J,Hermann DM,Doeppner TR

更新日期：2016-03-07 00:00:00

abstract：:The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

journal_title：Frontiers in cellular neuroscience

authors： Magalhães AC,Rivera C

更新日期：2016-08-17 00:00:00

abstract：:Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ...

journal_title：Frontiers in cellular neuroscience

authors： Juzekaeva E,Nasretdinov A,Gainutdinov A,Sintsov M,Mukhtarov M,Khazipov R

更新日期：2017-12-15 00:00:00

abstract：:The remarkable ability of the nervous system to modify its structure and function is mostly experience and activity modulated. The molecular basis of neuronal plasticity has been studied in higher behavioral processes, such as learning and memory formation. However, neuronal plasticity is not restricted to higher brai...

journal_title：Frontiers in cellular neuroscience

authors： Farca-Luna AJ,Sprecher SG

更新日期：2013-07-04 00:00:00

abstract：:Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...

journal_title：Frontiers in cellular neuroscience

authors： Chen C,Chencheng Z,Cuiying L,Xiaokun G

更新日期：2020-01-31 00:00:00

abstract：:Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms. The interpretation of these findings is generally based on the...

journal_title：Frontiers in cellular neuroscience

authors： Bragina L,Fattorini G,Giovedì S,Bosco F,Benfenati F,Conti F

更新日期：2013-02-04 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:The hippocampal mossy fibers (MFs), the axons of the granule cells (GCs) of the dentate gyrus, innervate mossy cells and interneurons in the hilus on their way to CA3 where they innervate interneurons and pyramidal cells. Synapses on each target cell have distinct anatomical and functional characteristics. In recent y...

journal_title：Frontiers in cellular neuroscience

authors： Münster-Wandowski A,Gómez-Lira G,Gutiérrez R

更新日期：2013-11-22 00:00:00

abstract：:Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses. At synaptic sites Shanks serve as scaffolding molecules that cluster neurotransmitter receptors as well as cell adhesion molecules attaching them to the actin c...

journal_title：Frontiers in cellular neuroscience

authors： Heise C,Schroeder JC,Schoen M,Halbedl S,Reim D,Woelfle S,Kreutz MR,Schmeisser MJ,Boeckers TM

更新日期：2016-04-26 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00

abstract：:The cerebellar cortex is remarkable for its organizational regularity, out of which task-related neural networks should emerge. In Purkinje cells, both complex and simple spike network patterns are evident in sensorimotor behavior. However, task-related patterns of activity in the granule cell layer (GCL) have been le...

journal_title：Frontiers in cellular neuroscience

authors： Courtemanche R,Chabaud P,Lamarre Y

更新日期：2009-07-20 00:00:00

abstract：:Recent research has revealed that uncontrolled chronic neuroinflammation is closely associated with diverse neurodegenerative diseases, by impairing blood-brain barrier (BBB) function and astrocytic reaction. Endoplasmic reticulum (ER) stress is conventionally linked to the loss of neuronal structure and function and ...

journal_title：Frontiers in cellular neuroscience

authors： Wang Y,Chen Y,Zhou Q,Xu J,Qian Q,Ni P,Qian Y

更新日期：2018-07-27 00:00:00

abstract：:AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which suggests a role in endo...

journal_title：Frontiers in cellular neuroscience

authors： Arnold M,Cross R,Singleton KS,Zlatic S,Chapleau C,Mullin AP,Rolle I,Moore CC,Theibert A,Pozzo-Miller L,Faundez V,Larimore J

更新日期：2016-09-22 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:The hippocampus is one of the earliest affected brain regions in Alzheimer's disease (AD) and its dysfunction is believed to underlie the core feature of the disease-memory impairment. Given that hippocampal volume is one of the best AD biomarkers, our review focuses on distinct subfields within the hippocampus, pinpo...

journal_title：Frontiers in cellular neuroscience

authors： Maruszak A,Thuret S

更新日期：2014-03-31 00:00:00