Characterization of Seeding Conditions for Studies on Differentiation Patterns of Subventricular Zone Derived Neurospheres.

abstract：:The malignancy of glioblastoma multiform (GBM), the most common and aggressive form of human brain tumors, strongly correlates with the presence of hypoxic areas, but the mechanisms controlling the hypoxia-induced aggressiveness are still unclear. GBM cells express a number of ion channels whose activity supports cell...

journal_title：Frontiers in cellular neuroscience

authors： Sforna L,Cenciarini M,Belia S,D'Adamo MC,Pessia M,Franciolini F,Catacuzzeno L

更新日期：2015-01-15 00:00:00

abstract：:The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility. Existence of mechanosensitive enteric neurons (MEN) is undoubted but many of their basic features remain to be studied. In ...

journal_title：Frontiers in cellular neuroscience

authors： Kugler EM,Michel K,Zeller F,Demir IE,Ceyhan GO,Schemann M,Mazzuoli-Weber G

更新日期：2015-09-15 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis, pregnancy morbidity and fetal loss caused by pathogenic autoantibodies directed against phospholipids (PL) and PL-cofactors. Isolated neurological APS may represent a significant diagnostic challenge, as epidemiological, clinical and n...

journal_title：Frontiers in cellular neuroscience

authors： D'Angelo C,Franch O,Fernández-Paredes L,Oreja-Guevara C,Núñez-Beltrán M,Comins-Boo A,Reale M,Sánchez-Ramón S

更新日期：2019-03-19 00:00:00

abstract：:Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major lim...

journal_title：Frontiers in cellular neuroscience

authors： Mohamud Yusuf A,Hagemann N,Schulten S,Rausch O,Wagner K,Hussner T,Qi Y,Totzeck M,Kleinschnitz C,Squire A,Gunzer M,Hermann DM

更新日期：2021-01-05 00:00:00

abstract：:The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis and migration processes. Moreover, genetic aberrations in WWOX i...

journal_title：Frontiers in cellular neuroscience

authors： Kośla K,Płuciennik E,Styczeń-Binkowska E,Nowakowska M,Orzechowska M,Bednarek AK

更新日期：2019-08-30 00:00:00

abstract：:Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we rec...

journal_title：Frontiers in cellular neuroscience

authors： Perche O,Felgerolle C,Ardourel M,Bazinet A,Pâris A,Rossignol R,Meyer-Dilhet G,Mausset-Bonnefont AL,Hébert B,Laurenceau D,Montécot-Dubourg C,Menuet A,Bizot JC,Pichon J,Ranchon-Cole I,Briault S

更新日期：2018-04-06 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during developm...

journal_title：Frontiers in cellular neuroscience

authors： Coppi E,Cellai L,Maraula G,Dettori I,Melani A,Pugliese AM,Pedata F

更新日期：2015-04-24 00:00:00

abstract：:Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in ...

journal_title：Frontiers in cellular neuroscience

authors： Dagostin AA,Lovell PV,Hilscher MM,Mello CV,Leão RM

更新日期：2015-12-10 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:The neuronal potassium-chloride co-transporter 2 [indicated thereafter as KCC2 (for protein) and Kcc2 (for gene)] is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2(+/+)) and Kcc2 deficient (K...

journal_title：Frontiers in cellular neuroscience

authors： Khalilov I,Chazal G,Chudotvorova I,Pellegrino C,Corby S,Ferrand N,Gubkina O,Nardou R,Tyzio R,Yamamoto S,Jentsch TJ,Hübner CA,Gaiarsa JL,Ben-Ari Y,Medina I

更新日期：2011-11-01 00:00:00

abstract：:The brain serotonin (5-hydroxytryptamine; 5-HT) system has been extensively studied for its role in normal physiology and behavior, as well as, neuropsychiatric disorders. The broad influence of 5-HT on brain function, is in part due to the vast connectivity pattern of 5-HT-producing neurons throughout the CNS. 5-HT n...

journal_title：Frontiers in cellular neuroscience

authors： Spencer WC,Deneris ES

更新日期：2017-07-19 00:00:00

abstract：:Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of exercise may vary with its regime. Less is known about how distinct e...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2017-01-31 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:Neurodegenerative diseases in general and specifically late-onset Alzheimer's disease (LOAD) involve a genetically complex and largely obscure ensemble of causative and risk factors accompanied by complex feedback responses. The advent of "high-throughput" transcriptome investigation technologies such as microarray an...

journal_title：Frontiers in cellular neuroscience

authors： Guffanti A,Simchovitz A,Soreq H

更新日期：2014-03-27 00:00:00

abstract：:Meningioma expressed antigen 6 (MEA6), also called cutaneous T cell lymphoma-associated antigen 5 (cTAGE5), was initially found in tumor tissues. MEA6 is located in endoplasmic reticulum (ER) exit sites and regulates the transport of collagen, very low density lipoprotein, and insulin. It is also reported that MEA6 mi...

journal_title：Frontiers in cellular neuroscience

authors： Wang XT,Cai XY,Xu FX,Zhou L,Zheng R,Ma KY,Xu ZH,Shen Y

更新日期：2019-06-11 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two progressive, fatal neurodegenerative syndromes with considerable clinical, genetic and pathological overlap. Clinical symptoms of FTD can be seen in ALS patients and vice versa. Recent genetic discoveries conclusively link the two diseases, ...

journal_title：Frontiers in cellular neuroscience

authors： Radford RA,Morsch M,Rayner SL,Cole NJ,Pountney DL,Chung RS

更新日期：2015-10-27 00:00:00

abstract：:Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA therapy has become one of the highest priorities in the stroke field. This mini review article focuse...

journal_title：Frontiers in cellular neuroscience

authors： Jiang Y,Fan X,Yu Z,Liao Z,Wang XS,van Leyen K,Sun X,Lo EH,Wang X

更新日期：2015-10-14 00:00:00

abstract：:Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known. The GluK2 subunit was recently shown to coexist in a functional complex with the neuronal K-Cl cotransporter KCC2. Apart ...

journal_title：Frontiers in cellular neuroscience

authors： Kesaf S,Khirug S,Dinh E,Saez Garcia M,Soni S,Orav E,Delpire E,Taira T,Lauri SE,Rivera C

更新日期：2020-08-26 00:00:00

abstract：:Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...

journal_title：Frontiers in cellular neuroscience

authors： Chen C,Chencheng Z,Cuiying L,Xiaokun G

更新日期：2020-01-31 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neuro...

journal_title：Frontiers in cellular neuroscience

authors： Atluri VS,Hidalgo M,Samikkannu T,Kurapati KR,Jayant RD,Sagar V,Nair MP

更新日期：2015-06-10 00:00:00

abstract：:Tonic GABA type A (GABAA) conductance is a key factor regulating neuronal excitability and computation in neuronal networks. The magnitude of the tonic GABAA conductance depends on the concentration of ambient GABA originating from vesicular and non-vesicular sources and is tightly regulated by GABA uptake. Here we sh...

journal_title：Frontiers in cellular neuroscience

authors： Song I,Volynski K,Brenner T,Ushkaryov Y,Walker M,Semyanov A

更新日期：2013-03-13 00:00:00

abstract：:Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS). Microglia-derived neuroinflammation has both beneficial and detrimental effects on neurons. Because the timing and magnitude of microglial activation is thought to be a cr...

journal_title：Frontiers in cellular neuroscience

authors： Konishi H,Kiyama H

更新日期：2018-08-06 00:00:00

abstract：:There is evidence for both neurotoxic and neuroprotective roles of nitric oxide (NO) in the brain and changes in the expression of the neuronal isoform of NO synthase (nNOS) gene occur during aging. The current studies have investigated potential support for either a neurotoxic or neuroprotective role of NO derived fr...

journal_title：Frontiers in cellular neuroscience

authors： James BM,Li Q,Luo L,Kendrick KM

更新日期：2015-03-27 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (±600 Hz). Since its early observations, the CS is known to vary in shape. In this study we describe CS waveforms, extracellularly recorded in awa...

journal_title：Frontiers in cellular neuroscience

authors： Warnaar P,Couto J,Negrello M,Junker M,Smilgin A,Ignashchenkova A,Giugliano M,Thier P,De Schutter E

更新日期：2015-04-13 00:00:00

abstract：:Gonadotropin releasing hormone-1 (GnRH-1) neurons play a pivotal role in controlling pubertal onset and fertility once they reach their hypothalamic location. During embryonic development, GnRH-1 neurons migrate from the nasal area to the hypothalamus where they modulate gonadotropin release from the pituitary gland. ...

journal_title：Frontiers in cellular neuroscience

authors： Taroc EZM,Lin JM,Tulloch AJ,Jaworski A,Forni PE

更新日期：2019-03-01 00:00:00

abstract：:Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of ni...

journal_title：Frontiers in cellular neuroscience

authors： Mahmoud MA,Fahmy GH,Moftah MZ,Sabry I

更新日期：2014-09-25 00:00:00