Purkinje Cell-Specific Knockout of Tyrosine Hydroxylase Impairs Cognitive Behaviors.

abstract：:Prenatal exposure to the antiepileptic drug valproic acid (VPA) induces autism spectrum disorder (ASD) in humans and autistic-like behaviors in rodents, which makes it a good model to study the neural underpinnings of ASD. Rats prenatally exposed to VPA show profound deficits in the social domain. The altered social b...

journal_title：Frontiers in cellular neuroscience

authors： Schiavi S,Iezzi D,Manduca A,Leone S,Melancia F,Carbone C,Petrella M,Mannaioni G,Masi A,Trezza V

更新日期：2019-10-25 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Aims: We have previously shown that the neurosteroid androstenediol (ADIOL) promotes remyelination following gliotoxin-induced demyelination. However, the impact of this ADIOL on axonal recovery is not yet known. In the present study, we investigated the impact of ADIOL on axonal integrity following a focal demyelinat...

journal_title：Frontiers in cellular neuroscience

authors： Kalakh S,Mouihate A

更新日期：2017-02-23 00:00:00

abstract：:Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic sign...

journal_title：Frontiers in cellular neuroscience

authors： Kékesi O,Ioja E,Szabó Z,Kardos J,Héja L

更新日期：2015-06-18 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:Neurodegenerative diseases in general and specifically late-onset Alzheimer's disease (LOAD) involve a genetically complex and largely obscure ensemble of causative and risk factors accompanied by complex feedback responses. The advent of "high-throughput" transcriptome investigation technologies such as microarray an...

journal_title：Frontiers in cellular neuroscience

authors： Guffanti A,Simchovitz A,Soreq H

更新日期：2014-03-27 00:00:00

abstract：:Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the way for personalized...

journal_title：Frontiers in cellular neuroscience

authors： Nassor F,Jarray R,Biard DSF,Maïza A,Papy-Garcia D,Pavoni S,Deslys JP,Yates F

更新日期：2020-02-11 00:00:00

abstract：:Prenatal hypoxic injury (HI) is a leading cause of neurological disability. The immediate and long-term effects of hypoxia on progenitor homeostasis and developmental progression during early human brain development remain unclear. This gap is due to difficulty to access human fetal brain tissues and inadequate animal...

journal_title：Frontiers in cellular neuroscience

authors： Daviaud N,Chevalier C,Friedel RH,Zou H

更新日期：2019-07-30 00:00:00

abstract：:Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have est...

journal_title：Frontiers in cellular neuroscience

authors： Neuhaus W,Gaiser F,Mahringer A,Franz J,Riethmüller C,Förster C

更新日期：2014-10-28 00:00:00

abstract：:Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ...

journal_title：Frontiers in cellular neuroscience

authors： Juzekaeva E,Nasretdinov A,Gainutdinov A,Sintsov M,Mukhtarov M,Khazipov R

更新日期：2017-12-15 00:00:00

abstract：:The blood-brain barrier (BBB) is a physical and biochemical barrier that maintains cerebral homeostasis. BBB dysfunction in an ischemic stroke, results in brain injury and subsequent neurological impairment. The aim of this study was to determine the possible protective effects of 1, 25-dihydroxyvitamin D3 [1, 25(OH)2...

journal_title：Frontiers in cellular neuroscience

authors： Guo T,Wang Y,Guo Y,Wu S,Chen W,Liu N,Wang Y,Geng D

更新日期：2018-12-17 00:00:00

abstract：:The hippocampal mossy fibers (MFs), the axons of the granule cells (GCs) of the dentate gyrus, innervate mossy cells and interneurons in the hilus on their way to CA3 where they innervate interneurons and pyramidal cells. Synapses on each target cell have distinct anatomical and functional characteristics. In recent y...

journal_title：Frontiers in cellular neuroscience

authors： Münster-Wandowski A,Gómez-Lira G,Gutiérrez R

更新日期：2013-11-22 00:00:00

abstract：:The piriform cortex (PC) is richly innervated by corticotropin-releasing factor (CRF) and serotonin (5-HT) containing axons arising from central amygdala and Raphe nucleus. CRFR1 and 5-HT2A/2CRs have been shown to interact in manner where CRFR activation subsequently potentiates the activity of 5-HT2A/2CRs. The purpos...

journal_title：Frontiers in cellular neuroscience

authors： Narla C,Dunn HA,Ferguson SS,Poulter MO

更新日期：2015-05-28 00:00:00

abstract：:Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have revealed diverse roles of Shank3 in the regulation of synaptic, ...

journal_title：Frontiers in cellular neuroscience

authors： Yoo T,Cho H,Lee J,Park H,Yoo YE,Yang E,Kim JY,Kim H,Kim E

更新日期：2018-10-09 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:To understand the potential role of enhanced hippocampal neurogenesis after pilocarpine-induced status epilepticus (SE) in the development of epilepsy, we quantitatively analyzed the geometry of apical dendrites, synaptic transmission, and activation levels of normotopically distributed mature newborn granule cells in...

journal_title：Frontiers in cellular neuroscience

authors： Gao F,Song X,Zhu D,Wang X,Hao A,Nadler JV,Zhan RZ

更新日期：2015-10-07 00:00:00

abstract：:Experimental and epidemiological data show that the severity and the duration of brain inflammation are attenuated in females compared to males. This attenuated brain inflammation is ascribed to 17β-estradiol. However, several studies suggest that 17β-estradiol is also endowed with proinflammatory properties. The aim ...

journal_title：Frontiers in cellular neuroscience

authors： Mouihate A

更新日期：2014-05-27 00:00:00

abstract：:Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less than 10% of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can p...

journal_title：Frontiers in cellular neuroscience

authors： Broughton BR,Lim R,Arumugam TV,Drummond GR,Wallace EM,Sobey CG

更新日期：2013-01-17 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which account for 55% of all neurological diseases, are the leading cause of permanent disability, cognitive and motor disorders and dementia. Stroke affects the function and structure of blood-brain barrier, the loss of cerebral blood fl...

journal_title：Frontiers in cellular neuroscience

authors： Posada-Duque RA,Barreto GE,Cardona-Gomez GP

更新日期：2014-08-14 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00

abstract：:The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air. Mechanisms coordinating the activities of different cell types within the MOE to maintain these functions are poorly understood. Previously, we showed that superficial...

journal_title：Frontiers in cellular neuroscience

authors： Fu Z,Ogura T,Luo W,Lin W

更新日期：2018-03-20 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples NMDAR activation to distinct intracellular signaling pathways, thus ...

journal_title：Frontiers in cellular neuroscience

authors： Fan X,Jin WY,Wang YT

更新日期：2014-06-10 00:00:00

abstract：:Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 and CaV2.2 types. Entering Ca2+ diffuses to a nearby calcium sensor associated with a docked synaptic vesicle (SV) and initiate...

journal_title：Frontiers in cellular neuroscience

authors： Snidal CA,Li Q,Elliott BB,Mah HK,Chen RHC,Gardezi SR,Stanley EF

更新日期：2018-05-11 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the key active regions of sAPPα is the central APP domain (E2) that conta...

journal_title：Frontiers in cellular neuroscience

authors： Morrissey JA,Bigus E,Necarsulmer JC,Srinivasan V,Peppercorn K,O'Leary DJ,Mockett BG,Tate WP,Hughes SM,Parfitt KD,Abraham WC

更新日期：2019-10-18 00:00:00