Recurrent seizure-like events are associated with coupled astroglial synchronization.

abstract：:The Purkinje cell (PC) is among the most complex neurons in the brain and plays a critical role for cerebellar functioning. PCs operate as fast pacemakers modulated by synaptic inputs but can switch from simple spikes to complex bursts and, in some conditions, show bistability. In contrast to original works emphasizin...

journal_title：Frontiers in cellular neuroscience

authors： Masoli S,Solinas S,D'Angelo E

更新日期：2015-02-24 00:00:00

abstract：:The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to co...

journal_title：Frontiers in cellular neuroscience

authors： Catts VS,Fung SJ,Long LE,Joshi D,Vercammen A,Allen KM,Fillman SG,Rothmond DA,Sinclair D,Tiwari Y,Tsai SY,Weickert TW,Shannon Weickert C

更新日期：2013-05-15 00:00:00

abstract：:Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or dis...

journal_title：Frontiers in cellular neuroscience

authors： Penas C,Navarro X

更新日期：2018-06-07 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a high prevalence rate. The core symptoms of ASD patients are impaired social communication and repetitive behavior. Genetic and environmental factors contribute to pathophysiology of ASD. Regarding environmental risk factors, it is kno...

journal_title：Frontiers in cellular neuroscience

authors： Kuo HY,Liu FC

更新日期：2018-11-20 00:00:00

abstract：:Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse popula...

journal_title：Frontiers in cellular neuroscience

authors： Ernst C,Morton CC

更新日期：2013-10-02 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. In response to Aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (CNS), facilitate Aβ a...

journal_title：Frontiers in cellular neuroscience

authors： Shippy DC,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Type 2 diabetes increases the risk for dementia, including Alzheimer's disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albeit through mostly u...

journal_title：Frontiers in cellular neuroscience

authors： Moosecker S,Gomes P,Dioli C,Yu S,Sotiropoulos I,Almeida OFX

更新日期：2019-06-12 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:Functional maturation of visual cortex is linked with dynamic changes in synaptic expression of GABAergic mechanisms. These include setting the excitation-inhibition balance required for experience-dependent plasticity, as well as, intracortical inhibition underlying development and aging of receptive field properties...

journal_title：Frontiers in cellular neuroscience

authors： Pinto JG,Hornby KR,Jones DG,Murphy KM

更新日期：2010-06-10 00:00:00

abstract：:Bone marrow-derived mononuclear cells (BM-MNCs) were shown to improve the outcome in animal stroke models and clinical pilot studies on BM-MNCs for stroke patients were already conducted. However, relevant aspects of pre-clinical evaluation, such as the use of animals with comorbidities and dose-response studies, were...

journal_title：Frontiers in cellular neuroscience

authors： Minnerup J,Wagner DC,Strecker JK,Pösel C,Sevimli-Abdis S,Schmidt A,Schilling M,Boltze J,Diederich K,Schäbitz WR

更新日期：2014-01-08 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal ...

journal_title：Frontiers in cellular neuroscience

authors： Mottahedin A,Ardalan M,Chumak T,Riebe I,Ek J,Mallard C

更新日期：2017-07-11 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder characterized by motor, psychiatric and cognitive symptoms. HD is caused by an expansion of CAG repeats in the huntingtin (HTT) gene in various areas of the brain including striatum. There are few suitable animal models to study th...

journal_title：Frontiers in cellular neuroscience

authors： Jang M,Lee SE,Cho IH

更新日期：2018-06-12 00:00:00

abstract：:Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in relation to their specific functions. Using a combination of two-phot...

journal_title：Frontiers in cellular neuroscience

authors： Chamberland S,Salesse C,Topolnik D,Topolnik L

更新日期：2010-10-15 00:00:00

abstract：:Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative s...

journal_title：Frontiers in cellular neuroscience

authors： Dinh CT,Goncalves S,Bas E,Van De Water TR,Zine A

更新日期：2015-03-31 00:00:00

abstract：:[This corrects the article on p. 56 in vol. 11, PMID: 28303091.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Owens R,Grabert K,Davies CL,Alfieri A,Antel JP,Healy LM,McColl BW

更新日期：2017-08-24 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis and migration processes. Moreover, genetic aberrations in WWOX i...

journal_title：Frontiers in cellular neuroscience

authors： Kośla K,Płuciennik E,Styczeń-Binkowska E,Nowakowska M,Orzechowska M,Bednarek AK

更新日期：2019-08-30 00:00:00

abstract：:Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer's disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial. Despite pathological findings of increased astrocytic mitosis in AD brains, in vitr...

journal_title：Frontiers in cellular neuroscience

authors： Ohki EC,Langan TJ,Rodgers KR,Chou RC

更新日期：2017-09-26 00:00:00

abstract：:The hippocampal mossy fibers (MFs), the axons of the granule cells (GCs) of the dentate gyrus, innervate mossy cells and interneurons in the hilus on their way to CA3 where they innervate interneurons and pyramidal cells. Synapses on each target cell have distinct anatomical and functional characteristics. In recent y...

journal_title：Frontiers in cellular neuroscience

authors： Münster-Wandowski A,Gómez-Lira G,Gutiérrez R

更新日期：2013-11-22 00:00:00

abstract：:A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or GABA receptors. ...

journal_title：Frontiers in cellular neuroscience

authors： DelaCuesta-Barrutia J,Peñagarikano O,Erdozain AM

更新日期：2020-10-30 00:00:00

abstract：:Gonadotropin releasing hormone-1 (GnRH-1) neurons play a pivotal role in controlling pubertal onset and fertility once they reach their hypothalamic location. During embryonic development, GnRH-1 neurons migrate from the nasal area to the hypothalamus where they modulate gonadotropin release from the pituitary gland. ...

journal_title：Frontiers in cellular neuroscience

authors： Taroc EZM,Lin JM,Tulloch AJ,Jaworski A,Forni PE

更新日期：2019-03-01 00:00:00

abstract：:The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

journal_title：Frontiers in cellular neuroscience

authors： Marx M,Haas CA,Häussler U

更新日期：2013-10-01 00:00:00

abstract：:Since monumental studies from scientists like His, Ramón y Cajal, Lorente de Nó and many others have put down roots for modern neuroscience, the scientific community has spent a considerable amount of time, and money, investigating any possible aspect of the evolution, development and function of neurons. Today, the c...

journal_title：Frontiers in cellular neuroscience

authors： Tomassy GS,Fossati V

更新日期：2014-07-28 00:00:00

abstract：:There is mounting evidence that oxidative glucose metabolism is impaired in epilepsy and recent work has further characterized the metabolic mechanisms involved. In healthy people eating a traditional diet, including carbohydrates, fats and protein, the major energy substrate in brain is glucose. Cytosolic glucose met...

journal_title：Frontiers in cellular neuroscience

authors： McDonald T,Puchowicz M,Borges K

更新日期：2018-08-31 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases us...

journal_title：Frontiers in cellular neuroscience

authors： Bonnamain V,Neveu I,Naveilhan P

更新日期：2012-04-11 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates unfolded protein response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Carboxyl Terminus HSP...

journal_title：Frontiers in cellular neuroscience

authors： Cabral Miranda F,Adão-Novaes J,Hauswirth WW,Linden R,Petrs-Silva H,Chiarini LB

更新日期：2015-01-09 00:00:00

abstract：:Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of exercise may vary with its regime. Less is known about how distinct e...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2017-01-31 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00