Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.

abstract：:Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characteriz...

journal_title：Frontiers in cellular neuroscience

authors： García-Parra P,Cavaliere F,Maroto M,Bilbao L,Obieta I,López de Munain A,Alava JI,Izeta A

更新日期：2012-03-14 00:00:00

abstract：:Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) ...

journal_title：Frontiers in cellular neuroscience

authors： Sheth S,Mukherjea D,Rybak LP,Ramkumar V

更新日期：2017-10-27 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a high prevalence rate. The core symptoms of ASD patients are impaired social communication and repetitive behavior. Genetic and environmental factors contribute to pathophysiology of ASD. Regarding environmental risk factors, it is kno...

journal_title：Frontiers in cellular neuroscience

authors： Kuo HY,Liu FC

更新日期：2018-11-20 00:00:00

abstract：:A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocy...

journal_title：Frontiers in cellular neuroscience

authors： Huntemer-Silveira A,Patil N,Brickner MA,Parr AM

更新日期：2021-01-11 00:00:00

abstract：:Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 and CaV2.2 types. Entering Ca2+ diffuses to a nearby calcium sensor associated with a docked synaptic vesicle (SV) and initiate...

journal_title：Frontiers in cellular neuroscience

authors： Snidal CA,Li Q,Elliott BB,Mah HK,Chen RHC,Gardezi SR,Stanley EF

更新日期：2018-05-11 00:00:00

abstract：:Huntington disease (HD) is an inherited neurodegenerative disease characterized by a clinical triad of motor, psychiatric and cognitive symptoms. HD is caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Homozygosity for the HD-causing mutation is extremely rare; thus, the majority of HD pati...

journal_title：Frontiers in cellular neuroscience

authors： Quirion JG,Parsons MP

更新日期：2019-07-17 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:Behavioral and electrophysiological studies of Alzheimer's disease (AD) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. Re...

journal_title：Frontiers in cellular neuroscience

authors： Erez H,Shemesh OA,Spira ME

更新日期：2014-02-10 00:00:00

abstract：BACKGROUND:Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local...

journal_title：Frontiers in cellular neuroscience

authors： Skardelly M,Gaber K,Burdack S,Scheidt F,Schuhmann MU,Hilbig H,Meixensberger J,Boltze J

更新日期：2014-10-14 00:00:00

abstract：:The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's ...

journal_title：Frontiers in cellular neuroscience

authors： Koizumi H,Morigaki R,Okita S,Nagahiro S,Kaji R,Nakagawa M,Goto S

更新日期：2013-05-17 00:00:00

abstract：:The microdomain that orchestrates action potential initiation in neurons is the axon initial segment (AIS). It has long been considered to be a rather homogeneous domain at the very proximal axon hillock with relatively stable length, particularly in cortical pyramidal cells. However, studies in other brain regions pa...

journal_title：Frontiers in cellular neuroscience

authors： Höfflin F,Jack A,Riedel C,Mack-Bucher J,Roos J,Corcelli C,Schultz C,Wahle P,Engelhardt M

更新日期：2017-11-06 00:00:00

abstract：:The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

journal_title：Frontiers in cellular neuroscience

authors： Marx M,Haas CA,Häussler U

更新日期：2013-10-01 00:00:00

abstract：:In relapsing-remitting multiple sclerosis (RRMS) subtype, the patient's brain itself is capable of repairing the damage, remyelinating the axon and recovering the neurological function. Cerebrospinal fluid (CSF) is in close proximity with brain parenchyma and contains a host of proteins and other molecules, which infl...

journal_title：Frontiers in cellular neuroscience

authors： Mathur D,Riffo-Campos AL,Castillo J,Haines JD,Vidaurre OG,Zhang F,Coret-Ferrer F,Casaccia P,Casanova B,Lopez-Rodas G

更新日期：2017-07-18 00:00:00

abstract：:It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child. Currently, common treatment for maternal depression has been the selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2-3% of pr...

journal_title：Frontiers in cellular neuroscience

authors： Olivier JD,Akerud H,Kaihola H,Pawluski JL,Skalkidou A,Högberg U,Sundström-Poromaa I

更新日期：2013-05-21 00:00:00

abstract：:Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of male rats that were exposed to gestational stress or not. We hypot...

journal_title：Frontiers in cellular neuroscience

authors： Walf AA,Frye CA

更新日期：2012-12-18 00:00:00

abstract：:Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS). Microglia-derived neuroinflammation has both beneficial and detrimental effects on neurons. Because the timing and magnitude of microglial activation is thought to be a cr...

journal_title：Frontiers in cellular neuroscience

authors： Konishi H,Kiyama H

更新日期：2018-08-06 00:00:00

abstract：:Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is still unclear. Based on our previous clinical stu...

journal_title：Frontiers in cellular neuroscience

authors： Yu S,Yu M,Bu Z,He P,Feng J

更新日期：2020-07-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an important factor. The physical substrate for the regulation of the transc...

journal_title：Frontiers in cellular neuroscience

authors： Lazo-Gómez R,Ramírez-Jarquín UN,Tovar-Y-Romo LB,Tapia R

更新日期：2013-12-05 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B) have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS mic...

journal_title：Frontiers in cellular neuroscience

authors： Garbuzova-Davis S,Sanberg PR

更新日期：2014-02-03 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Dyneins are a small class of molecular motors that bind to microtubules and walk toward their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements. In addition dyneins generate forces on microtubule arrays that power the beating of cilia and fla...

journal_title：Frontiers in cellular neuroscience

authors： Roossien DH,Miller KE,Gallo G

更新日期：2015-07-06 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:What is the function of dendritic spikes? One might argue that they provide conditions for neuronal plasticity or that they are essential for neural computation. However, despite a long history of dendritic research, the physiological relevance of dendritic spikes in brain function remains unknown. This could stem fro...

journal_title：Frontiers in cellular neuroscience

authors： Manita S,Miyakawa H,Kitamura K,Murayama M

更新日期：2017-02-15 00:00:00

abstract：:Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the sub-ventricular zone (SVZ) of the lateral ventricles (LV). SGZ newborn neurons are destined to the granular cell layer (GCL) of the DG, while ne...

journal_title：Frontiers in cellular neuroscience

authors： Bátiz LF,Castro MA,Burgos PV,Velásquez ZD,Muñoz RI,Lafourcade CA,Troncoso-Escudero P,Wyneken U

更新日期：2016-01-19 00:00:00

abstract：:The transcription factor Pax6 controls multiple aspects of forebrain development. Conditional deletion of Pax6 in embryonic mouse cortex causes increased proliferation of cortical progenitor cells and a concomitant decrease in neural differentiation. Notch signaling regulates the balance between proliferation and diff...

journal_title：Frontiers in cellular neuroscience

authors： Dorà E,Price DJ,Mason JO

更新日期：2019-03-06 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expressed in the CA2 region...

journal_title：Frontiers in cellular neuroscience

authors： Hayani H,Song I,Dityatev A

更新日期：2018-05-30 00:00:00

abstract：Background:The functional aspects of mast cell-microglia interactions are important in neuroinflammation. Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation. However, the role of mast cells in Lipopolysaccharide (LPS)-induced microglia activation, neuroinflammat...

journal_title：Frontiers in cellular neuroscience

authors： Dong H,Wang Y,Zhang X,Zhang X,Qian Y,Ding H,Zhang S

更新日期：2019-05-03 00:00:00