Loss of Pax6 Causes Regional Changes in Dll1 Expression in Developing Cerebral Cortex.

abstract：:In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor structures to drive movement. Despite their pivotal position and acknowledged diversity these neurons are traditionally separated into broad commissural and corticofugal types, and until now no attempt has been made at resolv...

journal_title：Frontiers in cellular neuroscience

authors： Oswald MJ,Tantirigama ML,Sonntag I,Hughes SM,Empson RM

更新日期：2013-10-16 00:00:00

abstract：:Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming. Developmental senescence has been reported during embryonic development in different organisms and structures, such as the...

journal_title：Frontiers in cellular neuroscience

authors： Magariños M,Barajas-Azpeleta R,Varela-Nieto I,R Aburto M

更新日期：2020-08-17 00:00:00

abstract：:The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's ...

journal_title：Frontiers in cellular neuroscience

authors： Koizumi H,Morigaki R,Okita S,Nagahiro S,Kaji R,Nakagawa M,Goto S

更新日期：2013-05-17 00:00:00

abstract：:P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response. P2X receptors constitute a gene family of calcium-permeable ATP-gated cation channels therefore the regulation of P2X signaling is critical for both membran...

journal_title：Frontiers in cellular neuroscience

authors： Bernier LP,Ase AR,Séguéla P

更新日期：2013-11-25 00:00:00

abstract：:Action potential-dependent release of synaptic vesicles and short-term synaptic plasticity are dynamically regulated by the endogenous Ca(2+) buffers that shape [Ca(2+)] profiles within a presynaptic bouton. Calmodulin is one of the most abundant presynaptic proteins and it binds Ca(2+) faster than any other character...

journal_title：Frontiers in cellular neuroscience

authors： Timofeeva Y,Volynski KE

更新日期：2015-07-01 00:00:00

abstract：:The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein's cationic cell penetrating peptide (CPP) motif protected neurons in the face of toxic leve...

journal_title：Frontiers in cellular neuroscience

authors： Moutal A,François-Moutal L,Brittain JM,Khanna M,Khanna R

更新日期：2015-01-26 00:00:00

abstract：:The remarkable ability of the nervous system to modify its structure and function is mostly experience and activity modulated. The molecular basis of neuronal plasticity has been studied in higher behavioral processes, such as learning and memory formation. However, neuronal plasticity is not restricted to higher brai...

journal_title：Frontiers in cellular neuroscience

authors： Farca-Luna AJ,Sprecher SG

更新日期：2013-07-04 00:00:00

abstract：:Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in relation to their specific functions. Using a combination of two-phot...

journal_title：Frontiers in cellular neuroscience

authors： Chamberland S,Salesse C,Topolnik D,Topolnik L

更新日期：2010-10-15 00:00:00

abstract：:The mammalian olfactory bulb (OB) displays robust activity-dependent plasticity throughout life. Dopaminergic (DA) neurons in the glomerular layer (GL) of the OB are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (TH) expression and dopamine production, followed by a substantial...

journal_title：Frontiers in cellular neuroscience

authors： Grier BD,Belluscio L,Cheetham CE

更新日期：2016-07-15 00:00:00

abstract：:Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, cap...

journal_title：Frontiers in cellular neuroscience

authors： Michalski JP,Kothary R

更新日期：2015-09-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis, pregnancy morbidity and fetal loss caused by pathogenic autoantibodies directed against phospholipids (PL) and PL-cofactors. Isolated neurological APS may represent a significant diagnostic challenge, as epidemiological, clinical and n...

journal_title：Frontiers in cellular neuroscience

authors： D'Angelo C,Franch O,Fernández-Paredes L,Oreja-Guevara C,Núñez-Beltrán M,Comins-Boo A,Reale M,Sánchez-Ramón S

更新日期：2019-03-19 00:00:00

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and e...

journal_title：Frontiers in cellular neuroscience

authors： Gelderblom M,Arunachalam P,Magnus T

更新日期：2014-11-05 00:00:00

abstract：:The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic mechanisms regulating fluid dynamics within these structures is critic...

journal_title：Frontiers in cellular neuroscience

authors： Talaei S,Schnee ME,Aaron KA,Ricci AJ

更新日期：2019-10-30 00:00:00

abstract：:Abnormal accumulation of protein inclusions in motor neurons has been known as a major pathological change in amyotrophic lateral sclerosis (ALS). Increasing numbers of proteins including mutant Cu, Zn-superoxide dismutase (SOD1) have been identified as constituents of pathological inclusions in a form of insoluble fi...

journal_title：Frontiers in cellular neuroscience

authors： Ogawa M,Furukawa Y

更新日期：2014-03-18 00:00:00

abstract：:Proper transport of the Parkinson's disease (PD) protein, α-synuclein (α-syn), is thought to be crucial for its localization and function at the synapse. Previous work has shown that defects in long distance transport within narrow caliber axons occur early in PD, but how such defects contribute to PD is unknown. Here...

journal_title：Frontiers in cellular neuroscience

authors： Anderson EN,Hirpa D,Zheng KH,Banerjee R,Gunawardena S

更新日期：2020-01-10 00:00:00

abstract：:Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in solid tumors. Here, we elucidated the function and possible molecular mechanisms of lncRNA KCNQ1OT1 in human glioma U87 and U251 cells. Quantitative Real-Time polymerase chain reaction (q...

journal_title：Frontiers in cellular neuroscience

authors： Gong W,Zheng J,Liu X,Liu Y,Guo J,Gao Y,Tao W,Chen J,Li Z,Ma J,Xue Y

更新日期：2017-03-22 00:00:00

abstract：:Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals. A focus in our laboratory for over 25 years has been how production of the pregnane neurosteroid, allopregnanolone, is regulated and the novel (i.e...

journal_title：Frontiers in cellular neuroscience

authors： Frye CA,Koonce CJ,Walf AA

更新日期：2014-04-09 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with e...

journal_title：Frontiers in cellular neuroscience

authors： Henriques A,Kastner S,Chatzikonstantinou E,Pitzer C,Plaas C,Kirsch F,Wafzig O,Krüger C,Spoelgen R,Gonzalez De Aguilar JL,Gretz N,Schneider A

更新日期：2015-01-20 00:00:00

abstract：:Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known. The GluK2 subunit was recently shown to coexist in a functional complex with the neuronal K-Cl cotransporter KCC2. Apart ...

journal_title：Frontiers in cellular neuroscience

authors： Kesaf S,Khirug S,Dinh E,Saez Garcia M,Soni S,Orav E,Delpire E,Taira T,Lauri SE,Rivera C

更新日期：2020-08-26 00:00:00

abstract：:A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in f...

journal_title：Frontiers in cellular neuroscience

authors： Krauth N,Khalil V,Jariwala M,Mermet-Joret N,Vestergaard AK,Capogna M,Nabavi S

更新日期：2020-05-12 00:00:00

abstract：:Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons, they are less useful for analyzing Ca2+ dynamics in astrocytes, w...

journal_title：Frontiers in cellular neuroscience

authors： Savtchouk I,Carriero G,Volterra A

更新日期：2018-04-13 00:00:00

abstract：:Autoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflammatory processes. O...

journal_title：Frontiers in cellular neuroscience

authors： Prajeeth CK,Dittrich-Breiholz O,Talbot SR,Robert PA,Huehn J,Stangel M

更新日期：2018-10-10 00:00:00

abstract：:Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such as dendrites, axons and somas, in th...

journal_title：Frontiers in cellular neuroscience

authors： Tominaga Y,Taketoshi M,Tominaga T

更新日期：2018-10-24 00:00:00

abstract：:Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown. Rabs are monomeric GTPases that act as molecular switches to regulate membrane trafficking by binding a wide range of effectors. Among the Rab GTPases, Rab5 ...

journal_title：Frontiers in cellular neuroscience

authors： Moya-Alvarado G,Gonzalez A,Stuardo N,Bronfman FC

更新日期：2018-12-17 00:00:00

abstract：:The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer's disease (AD). In the present work ...

journal_title：Frontiers in cellular neuroscience

authors： Toniolo S,Serra L,Olivito G,Marra C,Bozzali M,Cercignani M

更新日期：2018-11-20 00:00:00

abstract：:Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals. However, the mechanism underlying these protective effects remains unclear. We aimed to assess the effects ...

journal_title：Frontiers in cellular neuroscience

authors： Zhu W,Zhu J,Zhao S,Li J,Hou D,Zhang Y,Sun H

更新日期：2020-10-06 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00