Abstract:
:Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, capable of reacting to a changing CNS. This review is intended as a primer and guide, exploring how the past 5 years have fundamentally altered our appreciation of oligodendrocyte development and CNS myelination.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Michalski JP,Kothary Rdoi
10.3389/fncel.2015.00340subject
Has Abstractpub_date
2015-09-01 00:00:00pages
340issn
1662-5102journal_volume
9pub_type
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journal_title:Frontiers in cellular neuroscience
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abstract::The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by progressive muscle weakness and spasticity, remains largely unknown. Approximately 5-10% of cases are familial, and of those, 15-20% are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). ...
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journal_title:Frontiers in cellular neuroscience
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