Abstract:
:Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connections. However, much of the details about the exact role of force in these fundamental processes remain unknown. In this review, we highlight: (1) standing questions concerning the role of mechanical force in axonal growth and guidance; and (2) different experimental techniques used to quantify forces in axons and growth cones. We believe that satisfying answers to these questions will require quantitative information about the relationship between elongation, forces, cytoskeletal dynamics, axonal transport, signaling, substrate adhesion, and stiffness contributing to directional growth advance. Furthermore, we address why a wide range of force values have been reported in the literature, and what these values mean in the context of neuronal mechanics. We hope that this review will provide a guide for those interested in studying the role of force in development and regeneration of neuronal networks.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Athamneh AI,Suter DMdoi
10.3389/fncel.2015.00359subject
Has Abstractpub_date
2015-09-16 00:00:00pages
359issn
1662-5102journal_volume
9pub_type
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abstract::[This corrects the article DOI: 10.3389/fncel.2018.00209.]. ...
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