Light Sheet Microscopy Using FITC-Albumin Followed by Immunohistochemistry of the Same Rehydrated Brains Reveals Ischemic Brain Injury and Early Microvascular Remodeling.

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Morigaki R,Okita S,Goto S

更新日期：2017-02-10 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:The present study was designed to observe the effect of COX2/PGD2-related autophagy on brain injury in type 2 diabetes rats. The histopathology was detected by haematoxylin-eosin staining. The learning and memory functions were evaluated by Morris water maze. The levels of insulin and PGD2 were measured by enzyme-link...

journal_title：Frontiers in cellular neuroscience

authors： Yang Y,Chen Q,Zhao Q,Luo Y,Xu Y,Du W,Wang H,Li H,Yang L,Hu C,Zhang J,Li Y,Xia H,Chen Z,Ma J,Tian X,Yang J

更新日期：2019-02-27 00:00:00

abstract：:Neurodegenerative diseases in general and specifically late-onset Alzheimer's disease (LOAD) involve a genetically complex and largely obscure ensemble of causative and risk factors accompanied by complex feedback responses. The advent of "high-throughput" transcriptome investigation technologies such as microarray an...

journal_title：Frontiers in cellular neuroscience

authors： Guffanti A,Simchovitz A,Soreq H

更新日期：2014-03-27 00:00:00

abstract：:Central pattern generators (CPGs) in the thoracolumbar spinal cord generate the basic hindlimb locomotor pattern. The locomotor CPG integrates descending commands and sensory information from the periphery to activate, modulate and halt the rhythmic program. General CPG function and response to sensory perturbations a...

journal_title：Frontiers in cellular neuroscience

authors： Li EZ,Garcia-Ramirez DL,Dougherty KJ

更新日期：2019-10-09 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have est...

journal_title：Frontiers in cellular neuroscience

authors： Neuhaus W,Gaiser F,Mahringer A,Franz J,Riethmüller C,Förster C

更新日期：2014-10-28 00:00:00

abstract：:The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

journal_title：Frontiers in cellular neuroscience

authors： Magalhães AC,Rivera C

更新日期：2016-08-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2017.00013.]. ...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2019-07-09 00:00:00

abstract：:Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are believed to represent the different outcomes of a common pathogenic mechanism. However, while researchers have intensely studied the involvement of motor neurons in the ALS/FTD syndrome, very little is known about the function of hippocampal neu...

journal_title：Frontiers in cellular neuroscience

authors： Radzicki D,Liu E,Deng HX,Siddique T,Martina M

更新日期：2016-09-20 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composi...

journal_title：Frontiers in cellular neuroscience

authors： Kelly EA,Russo AS,Jackson CD,Lamantia CE,Majewska AK

更新日期：2015-09-22 00:00:00

abstract：:Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake...

journal_title：Frontiers in cellular neuroscience

authors： Francavilla R,Villette V,Martel O,Topolnik L

更新日期：2019-03-15 00:00:00

abstract：:Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression. These effects have been linked to glial cell activation, glutamate release and changes in neuronal plasticity and survival including atrophy of hippoc...

journal_title：Frontiers in cellular neuroscience

authors： Orellana JA,Moraga-Amaro R,Díaz-Galarce R,Rojas S,Maturana CJ,Stehberg J,Sáez JC

更新日期：2015-04-02 00:00:00

abstract：:The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expressed in the CA2 region...

journal_title：Frontiers in cellular neuroscience

authors： Hayani H,Song I,Dityatev A

更新日期：2018-05-30 00:00:00

abstract：:The neuronal potassium-chloride co-transporter 2 [indicated thereafter as KCC2 (for protein) and Kcc2 (for gene)] is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2(+/+)) and Kcc2 deficient (K...

journal_title：Frontiers in cellular neuroscience

authors： Khalilov I,Chazal G,Chudotvorova I,Pellegrino C,Corby S,Ferrand N,Gubkina O,Nardou R,Tyzio R,Yamamoto S,Jentsch TJ,Hübner CA,Gaiarsa JL,Ben-Ari Y,Medina I

更新日期：2011-11-01 00:00:00

abstract：:Intermittent fasting (IF) was suggested to be a powerful nutritional strategy to prevent the onset of age-related neurodegenerative diseases associated with compromised brain bioenergetics. Whether the application of IF in combination with a mitochondrial insult could buffer the neurodegenerative process has never bee...

journal_title：Frontiers in cellular neuroscience

authors： Tatulli G,Mitro N,Cannata SM,Audano M,Caruso D,D'Arcangelo G,Lettieri-Barbato D,Aquilano K

更新日期：2018-01-17 00:00:00

abstract：:Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral ischemic injury. In this work, we explored whether NT-1 can be steadily overexpressed by adeno-associated virus (AAV) and the exogenous NT-1 can promote neural stem cells...

journal_title：Frontiers in cellular neuroscience

authors： Lu H,Song X,Wang F,Wang G,Wu Y,Wang Q,Wang Y,Yang GY,Zhang Z

更新日期：2016-09-30 00:00:00

abstract：:Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or "tether" (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) whi...

journal_title：Frontiers in cellular neuroscience

authors： Wong FK,Nath AR,Chen RH,Gardezi SR,Li Q,Stanley EF

更新日期：2014-03-07 00:00:00

abstract：:Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer, and integrate into neural networks encoding spatial and contextu...

journal_title：Frontiers in cellular neuroscience

authors： Belarbi K,Rosi S

更新日期：2013-09-06 00:00:00

abstract：:Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, cap...

journal_title：Frontiers in cellular neuroscience

authors： Michalski JP,Kothary R

更新日期：2015-09-01 00:00:00

abstract：:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role ...

journal_title：Frontiers in cellular neuroscience

authors： Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska E

更新日期：2015-03-11 00:00:00

abstract：:Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal...

journal_title：Frontiers in cellular neuroscience

authors： Anilkumar U,Prehn JH

更新日期：2014-09-30 00:00:00

abstract：:Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse popula...

journal_title：Frontiers in cellular neuroscience

authors： Ernst C,Morton CC

更新日期：2013-10-02 00:00:00

abstract：:Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer's disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important pr...

journal_title：Frontiers in cellular neuroscience

authors： Toral-Rios D,Franco-Bocanegra D,Rosas-Carrasco O,Mena-Barranco F,Carvajal-García R,Meraz-Ríos MA,Campos-Peña V

更新日期：2015-05-18 00:00:00

abstract：:The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity. Glial cells can produce and release neurotransmitter-like molec...

journal_title：Frontiers in cellular neuroscience

authors： Van Horn MR,Sild M,Ruthazer ES

更新日期：2013-04-23 00:00:00

abstract：:Neuron-glia interactions contribute to tissue homeostasis and functional plasticity in the mammalian brain, but it remains unclear how this is achieved. The potential of central auditory brain tissue for stimulation-dependent cellular remodeling was studied in hearing-experienced and neonatally deafened rats. At adult...

journal_title：Frontiers in cellular neuroscience

authors： Rosskothen-Kuhl N,Hildebrandt H,Birkenhäger R,Illing RB

更新日期：2018-02-22 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting both upper and lower motor neurons. The molecular mechanisms underlying disease pathogenesis remain largely unknown. Multiple genetic loci including genes involved in proteostasis and ribostasis have been linked to ALS p...

journal_title：Frontiers in cellular neuroscience

authors： Coyne AN,Zaepfel BL,Zarnescu DC

更新日期：2017-08-17 00:00:00

abstract：:Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses. At synaptic sites Shanks serve as scaffolding molecules that cluster neurotransmitter receptors as well as cell adhesion molecules attaching them to the actin c...

journal_title：Frontiers in cellular neuroscience

authors： Heise C,Schroeder JC,Schoen M,Halbedl S,Reim D,Woelfle S,Kreutz MR,Schmeisser MJ,Boeckers TM

更新日期：2016-04-26 00:00:00