Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia.

abstract：:Current research indicates that the causes of autism spectrum disorders (ASDs) are multifactorial and include both genetic and environmental factors. To date, several works have associated ASDs with mutations in genes that encode proteins involved in neuronal synapses; however other factors and the way they can intera...

journal_title：Frontiers in cellular neuroscience

authors： Gámez-Del-Estal MM,Contreras I,Prieto-Pérez R,Ruiz-Rubio M

更新日期：2014-03-04 00:00:00

abstract：:The neuronal potassium-chloride co-transporter 2 [indicated thereafter as KCC2 (for protein) and Kcc2 (for gene)] is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2(+/+)) and Kcc2 deficient (K...

journal_title：Frontiers in cellular neuroscience

authors： Khalilov I,Chazal G,Chudotvorova I,Pellegrino C,Corby S,Ferrand N,Gubkina O,Nardou R,Tyzio R,Yamamoto S,Jentsch TJ,Hübner CA,Gaiarsa JL,Ben-Ari Y,Medina I

更新日期：2011-11-01 00:00:00

abstract：:The present study was designed to observe the effect of COX2/PGD2-related autophagy on brain injury in type 2 diabetes rats. The histopathology was detected by haematoxylin-eosin staining. The learning and memory functions were evaluated by Morris water maze. The levels of insulin and PGD2 were measured by enzyme-link...

journal_title：Frontiers in cellular neuroscience

authors： Yang Y,Chen Q,Zhao Q,Luo Y,Xu Y,Du W,Wang H,Li H,Yang L,Hu C,Zhang J,Li Y,Xia H,Chen Z,Ma J,Tian X,Yang J

更新日期：2019-02-27 00:00:00

abstract：:Intermittent fasting (IF) was suggested to be a powerful nutritional strategy to prevent the onset of age-related neurodegenerative diseases associated with compromised brain bioenergetics. Whether the application of IF in combination with a mitochondrial insult could buffer the neurodegenerative process has never bee...

journal_title：Frontiers in cellular neuroscience

authors： Tatulli G,Mitro N,Cannata SM,Audano M,Caruso D,D'Arcangelo G,Lettieri-Barbato D,Aquilano K

更新日期：2018-01-17 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocy...

journal_title：Frontiers in cellular neuroscience

authors： Huntemer-Silveira A,Patil N,Brickner MA,Parr AM

更新日期：2021-01-11 00:00:00

abstract：:Understanding synaptic connectivity and plasticity within brain circuits and their relationship to learning and behavior is a fundamental quest in neuroscience. Visualizing the fine details of synapses using optical microscopy remains however a major technical challenge. Super resolution microscopy opens the possibili...

journal_title：Frontiers in cellular neuroscience

authors： Spühler IA,Conley GM,Scheffold F,Sprecher SG

更新日期：2016-05-26 00:00:00

abstract：:Natural products have attracted interest in the search for new and effective analgesics and coadjuvant approaches to several types of pain. It is in fact well known that many of their active ingredients, such as anthocyanins (ACNs) and polyphenols, can exert potent anti-inflammatory actions. Nevertheless, their potent...

journal_title：Frontiers in cellular neuroscience

authors： Magni G,Marinelli A,Riccio D,Lecca D,Tonelli C,Abbracchio MP,Petroni K,Ceruti S

更新日期：2018-11-05 00:00:00

abstract：:Hybridization of sympatric closely related species may sometimes lead to introgression and speciation. The sister species Helicoverpa armigera and Helicoverpa assulta both use (Z)-11-hexadecenal and (Z)-9-hexadecenal as sex pheromone components but in reversed ratios. Female H. armigera and male H. assulta could hybri...

journal_title：Frontiers in cellular neuroscience

authors： Xu M,Dong JF,Wu H,Zhao XC,Huang LQ,Wang CZ

更新日期：2017-01-10 00:00:00

abstract：:Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes. However, mild strokes have a better prospect for functional recovery. Recently, anatomic and behavioral changes have been reported for distal...

journal_title：Frontiers in cellular neuroscience

authors： Minassian A,Green C,Diedenhofen M,Vogel S,Hess S,Stoeber M,Radmilovic MD,Wiedermann D,Kloppenburg P,Hoehn M

更新日期：2020-04-07 00:00:00

abstract：:Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes mortality and long-term neurological impairments. Our previous study demonstrated activation of CD11b+ myeloid cells, including residential microglial cells (MGs) and infiltrating monocyte-derived macrophages (MDMs) in a murine mo...

journal_title：Frontiers in cellular neuroscience

authors： Min Y,Yan L,Wang Q,Wang F,Hua H,Yuan Y,Jin H,Zhang M,Zhao Y,Yang J,Jiang X,Yang Y,Li F

更新日期：2020-08-10 00:00:00

abstract：:Spatially localized proteolysis represents an elegant means by which neuronal activity dependent changes in synaptic structure, and thus experience dependent learning and memory, can be achieved. In vitro and in vivo studies suggest that matrix metalloproteinase and adamalysin activity is concentrated at the cell surf...

journal_title：Frontiers in cellular neuroscience

authors： Conant K,Allen M,Lim ST

更新日期：2015-08-11 00:00:00

abstract：:The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1's rol...

journal_title：Frontiers in cellular neuroscience

authors： Ng F,Wijaya L,Tang BL

更新日期：2015-03-09 00:00:00

abstract：:Alteration of glutamatergic synaptic plasticity in the Nucleus Accumbens (NAc) has been implicated in cocaine-seeking behaviors. Astroglial mechanisms for maintaining extracellular glutamate homeostasis through cysteine/glutamate exchanger (xCT) and glutamate transporter GLT1 are dysregulated following cocaine exposur...

journal_title：Frontiers in cellular neuroscience

authors： Jarvis R,Tamashiro-Orrego A,Promes V,Tu L,Shi J,Yang Y

更新日期：2020-01-10 00:00:00

abstract：:Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

journal_title：Frontiers in cellular neuroscience

authors： Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

更新日期：2013-08-12 00:00:00

abstract：:Schizophrenia affects more than 1% of the world's population and shows very high heterogeneity in the positive, negative, and cognitive symptoms experienced by patients. The pathogenic mechanisms underlying this neurodevelopmental disorder are largely unknown, although it is proposed to emerge from multiple genetic an...

journal_title：Frontiers in cellular neuroscience

authors： Carrier M,Guilbert J,Lévesque JP,Tremblay MÈ,Desjardins M

更新日期：2021-01-15 00:00:00

abstract：:Central pattern generators (CPGs) in the thoracolumbar spinal cord generate the basic hindlimb locomotor pattern. The locomotor CPG integrates descending commands and sensory information from the periphery to activate, modulate and halt the rhythmic program. General CPG function and response to sensory perturbations a...

journal_title：Frontiers in cellular neuroscience

authors： Li EZ,Garcia-Ramirez DL,Dougherty KJ

更新日期：2019-10-09 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:Microglial activation is a key pathogenic process at the onset of Alzheimer's disease (AD). Identifying regulators of microglial activation bears great potential in elucidating causes and mechanisms of AD and determining candidates for early intervention. Previous studies demonstrate abnormal elevation of glutaminase ...

journal_title：Frontiers in cellular neuroscience

authors： Gao G,Zhao S,Xia X,Li C,Li C,Ji C,Sheng S,Tang Y,Zhu J,Wang Y,Huang Y,Zheng JC

更新日期：2019-06-28 00:00:00

abstract：:Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinerg...

journal_title：Frontiers in cellular neuroscience

authors： Latina V,Caioli S,Zona C,Ciotti MT,Amadoro G,Calissano P

更新日期：2017-03-15 00:00:00

abstract：:Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS). Genome-wide association studies in humans have associated ADCY3 with major depressive disorder and autistic spectrum disorder, both of which exhibit sexual dimorphism. To date, it is ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou Y,Qiu L,Sterpka A,Wang H,Chu F,Chen X

更新日期：2019-02-13 00:00:00

abstract：:Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we rec...

journal_title：Frontiers in cellular neuroscience

authors： Perche O,Felgerolle C,Ardourel M,Bazinet A,Pâris A,Rossignol R,Meyer-Dilhet G,Mausset-Bonnefont AL,Hébert B,Laurenceau D,Montécot-Dubourg C,Menuet A,Bizot JC,Pichon J,Ranchon-Cole I,Briault S

更新日期：2018-04-06 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Rac1 is a major player of the Rho family of small GTPases that controls multiple cell signaling pathways, such as the organization of cytoskeleton (including adhesion and motility), cell proliferation, apoptosis and activation of immune cells. In the nervous system, in particular, Rac1 GTPase plays a key regulatory fu...

journal_title：Frontiers in cellular neuroscience

authors： D'Ambrosi N,Rossi S,Gerbino V,Cozzolino M

更新日期：2014-09-08 00:00:00

abstract：:In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor structures to drive movement. Despite their pivotal position and acknowledged diversity these neurons are traditionally separated into broad commissural and corticofugal types, and until now no attempt has been made at resolv...

journal_title：Frontiers in cellular neuroscience

authors： Oswald MJ,Tantirigama ML,Sonntag I,Hughes SM,Empson RM

更新日期：2013-10-16 00:00:00

abstract：:The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711-729). Four main currents were shown to be involved, namely a persistent sodium current (I(Na-p)), an h current (I(h)), an SK-type calcium-dependent potassium current (I(K-AHP)), and a slow M-like potassium cur...

journal_title：Frontiers in cellular neuroscience

authors： Solinas S,Forti L,Cesana E,Mapelli J,De Schutter E,D'Angelo E

更新日期：2007-12-30 00:00:00