Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons.

abstract：:The adult hypothalamus regulates many physiological functions and homeostatic loops, including growth, feeding and reproduction. In mammals, the hypothalamus derives from the ventral diencephalon where two distinct ventricular proliferative zones have been described. Although a set of transcription factors regulating ...

journal_title：Frontiers in cellular neuroscience

authors： Maggi R,Zasso J,Conti L

更新日期：2015-01-06 00:00:00

abstract：:[This corrects the article on p. 396 in vol. 8, PMID: 25505873.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Frontiers Production Office.

更新日期：2015-04-23 00:00:00

abstract：PURPOSE:Retinitis pigmentosa includes a group of progressive retinal degenerative diseases that affect the structure and function of photoreceptors. Secondarily to the loss of photoreceptors, there is a reduction in retinal vascularization, which seems to influence the cellular degenerative process. Retinal macroglial ...

journal_title：Frontiers in cellular neuroscience

authors： Fernández-Sánchez L,Lax P,Campello L,Pinilla I,Cuenca N

更新日期：2015-12-22 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) ...

journal_title：Frontiers in cellular neuroscience

authors： Sheth S,Mukherjea D,Rybak LP,Ramkumar V

更新日期：2017-10-27 00:00:00

abstract：:Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3' untranslated region (3'UTR). Variations in length and sequence of the 3'UTR may underlie changes of post-transcriptional processing, localization, miRNA targeting and stabilit...

journal_title：Frontiers in cellular neuroscience

authors： Grassi E,Santoro R,Umbach A,Grosso A,Oliviero S,Neri F,Conti L,Ala U,Provero P,DiCunto F,Merlo GR

更新日期：2019-01-10 00:00:00

abstract：:Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or dis...

journal_title：Frontiers in cellular neuroscience

authors： Penas C,Navarro X

更新日期：2018-06-07 00:00:00

abstract：:Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

journal_title：Frontiers in cellular neuroscience

authors： Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

更新日期：2013-08-12 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Brain injuries of different etiologies lead to irreversible neuronal loss and persisting neuronal deficits. New therapeutic strategies are emerging to compensate neuronal damage upon brain injury. Some of these strategies focus on enhancing endogenous generation of neurons from neural stem cells (NSCs) to substitute t...

journal_title：Frontiers in cellular neuroscience

authors： García-Bernal F,Geribaldi-Doldán N,Domínguez-García S,Carrasco M,Murillo-Carretero M,Delgado-Ariza A,Díez-Salguero M,Verástegui C,Castro C

更新日期：2018-11-27 00:00:00

abstract：:Tonic GABA type A (GABAA) conductance is a key factor regulating neuronal excitability and computation in neuronal networks. The magnitude of the tonic GABAA conductance depends on the concentration of ambient GABA originating from vesicular and non-vesicular sources and is tightly regulated by GABA uptake. Here we sh...

journal_title：Frontiers in cellular neuroscience

authors： Song I,Volynski K,Brenner T,Ushkaryov Y,Walker M,Semyanov A

更新日期：2013-03-13 00:00:00

abstract：:Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes mortality and long-term neurological impairments. Our previous study demonstrated activation of CD11b+ myeloid cells, including residential microglial cells (MGs) and infiltrating monocyte-derived macrophages (MDMs) in a murine mo...

journal_title：Frontiers in cellular neuroscience

authors： Min Y,Yan L,Wang Q,Wang F,Hua H,Yuan Y,Jin H,Zhang M,Zhao Y,Yang J,Jiang X,Yang Y,Li F

更新日期：2020-08-10 00:00:00

abstract：:Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression. These effects have been linked to glial cell activation, glutamate release and changes in neuronal plasticity and survival including atrophy of hippoc...

journal_title：Frontiers in cellular neuroscience

authors： Orellana JA,Moraga-Amaro R,Díaz-Galarce R,Rojas S,Maturana CJ,Stehberg J,Sáez JC

更新日期：2015-04-02 00:00:00

abstract：:The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These ...

journal_title：Frontiers in cellular neuroscience

authors： Andersson MN,Corcoran JA,Zhang DD,Hillbur Y,Newcomb RD,Löfstedt C

更新日期：2016-09-07 00:00:00

abstract：:The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composi...

journal_title：Frontiers in cellular neuroscience

authors： Kelly EA,Russo AS,Jackson CD,Lamantia CE,Majewska AK

更新日期：2015-09-22 00:00:00

abstract：:Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major lim...

journal_title：Frontiers in cellular neuroscience

authors： Mohamud Yusuf A,Hagemann N,Schulten S,Rausch O,Wagner K,Hussner T,Qi Y,Totzeck M,Kleinschnitz C,Squire A,Gunzer M,Hermann DM

更新日期：2021-01-05 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of male rats that were exposed to gestational stress or not. We hypot...

journal_title：Frontiers in cellular neuroscience

authors： Walf AA,Frye CA

更新日期：2012-12-18 00:00:00

abstract：:We live in a world continuously immersed in noise, an environmental, recreational, and occupational factor present in almost every daily human activity. Exposure to high-level noise could affect the auditory function of individuals at any age, resulting in a condition called noise-induced hearing loss (NIHL). Given th...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado JC,Fuentes-Santamaría V,Juiz JM

更新日期：2020-07-22 00:00:00

abstract：:Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are man...

journal_title：Frontiers in cellular neuroscience

authors： Lee HK,Kirkwood A

更新日期：2019-12-03 00:00:00

abstract：:Brain edema formation and the ensuing brain damages are the major cause of high mortality and long term disability following the occurrence of ischemic stroke. In this process, oxygen and glucose deprivation and the resulting reperfusion injury play primary roles. In response to the ischemic insult, the neurovascular ...

journal_title：Frontiers in cellular neuroscience

authors： Wang YF,Parpura V

更新日期：2016-05-13 00:00:00

abstract：:Distal astrocytic processes have a complex morphology, reminiscent of branchlets and leaflets. Astrocytic branchlets are rod-like processes containing mitochondria and endoplasmic reticulum, capable of generating inositol-3-phosphate (IP3)-dependent Ca2+ signals. Leaflets are small and flat processes that protrude fro...

journal_title：Frontiers in cellular neuroscience

authors： Gavrilov N,Golyagina I,Brazhe A,Scimemi A,Turlapov V,Semyanov A

更新日期：2018-08-17 00:00:00

abstract：:Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the symptoms of epilepsy without providing disease-modifying benefits. Ion...

journal_title：Frontiers in cellular neuroscience

authors： Wilson SM,Ki Yeon S,Yang XF,Park KD,Khanna R

更新日期：2014-05-28 00:00:00

abstract：:Exposing developing cerebellar Purkinje neurons (PNs) to mutant Ataxin1 (ATXN1) in 82Q spinocerebellar ataxia type 1 (SCA1) mice disrupts motor behavior and cerebellar climbing fiber (CF) architecture from as early as 4 weeks of age. In contrast, if mutant ATXN1 expression is silenced until after cerebellar developmen...

journal_title：Frontiers in cellular neuroscience

authors： Ibrahim MF,Power EM,Potapov K,Empson RM

更新日期：2017-09-20 00:00:00

abstract：:Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connection...

journal_title：Frontiers in cellular neuroscience

authors： Athamneh AI,Suter DM

更新日期：2015-09-16 00:00:00

abstract：:Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer's disease (AD), continually fail clinical trials. We investigated whether this was due to the change in the e...

journal_title：Frontiers in cellular neuroscience

authors： Petrache AL,Khan AA,Nicholson MW,Monaco A,Kuta-Siejkowska M,Haider S,Hilton S,Jovanovic JN,Ali AB

更新日期：2020-11-11 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines in vitro to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might b...

journal_title：Frontiers in cellular neuroscience

authors： Re S,Dogan AA,Ben-Shachar D,Berger G,Werling AM,Walitza S,Grünblatt E

更新日期：2018-09-25 00:00:00

abstract：:The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic mechanisms regulating fluid dynamics within these structures is critic...

journal_title：Frontiers in cellular neuroscience

authors： Talaei S,Schnee ME,Aaron KA,Ricci AJ

更新日期：2019-10-30 00:00:00

abstract：:Microglia is increasingly recognized to play a crucial role in the pathogenesis of psychiatric diseases. In particular, microglia may be the cellular link between inflammation and behavioral alterations: by releasing a number of soluble factors, among which pro-inflammatory cytokines, that can regulate synaptic activi...

journal_title：Frontiers in cellular neuroscience

authors： Gentile A,De Vito F,Fresegna D,Musella A,Buttari F,Bullitta S,Mandolesi G,Centonze D

更新日期：2015-06-25 00:00:00