Abstract:
:Microglia is increasingly recognized to play a crucial role in the pathogenesis of psychiatric diseases. In particular, microglia may be the cellular link between inflammation and behavioral alterations: by releasing a number of soluble factors, among which pro-inflammatory cytokines, that can regulate synaptic activity, thereby leading to perturbation of behavior. In multiple sclerosis (MS), the most common neuroinflammatory disorder affecting young adults, microglia activation and dysfunction may account for mood symptoms, like depression and anxiety, that are often diagnosed in patients even in the absence of motor disability. Behavioral studies in experimental autoimmune encephalomyelitis (EAE), the animal model of MS, have shown that emotional changes occur early in the disease and in correlation to inflammatory mediator and neurotransmitter level alterations. However, such studies lack a full and comprehensive analysis of the role played by microglia in EAE-behavioral syndrome. We review the experimental studies addressing behavioral symptoms in EAE, and propose the study of neuron-glia interaction as a powerful but still poorly explored tool to investigate the burden of microglia in mood alterations associated to MS.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Gentile A,De Vito F,Fresegna D,Musella A,Buttari F,Bullitta S,Mandolesi G,Centonze Ddoi
10.3389/fncel.2015.00243subject
Has Abstractpub_date
2015-06-25 00:00:00pages
243issn
1662-5102journal_volume
9pub_type
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2017.00353
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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