Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.

abstract：:Increased expression of S100B and its specific receptor for advanced glycation end products (RAGE) has been described in patients with multiple sclerosis (MS), being associated with an active demyelinating process. We previously showed that a direct neutralization of S100B reduces lysophosphatidylcholine (LPC)-induced...

journal_title：Frontiers in cellular neuroscience

authors： Santos G,Barateiro A,Brites D,Fernandes A

更新日期：2020-09-04 00:00:00

abstract：:Genetically encoded Ca(2+) indicators (GECIs) are promising tools for cell type-specific and chronic recording of neuronal activity. In the mammalian central nervous system, however, GECIs have been tested almost exclusively in cortical and hippocampal pyramidal cells, and the usefulness of recently developed GECIs ha...

journal_title：Frontiers in cellular neuroscience

authors： Yamada Y,Michikawa T,Hashimoto M,Horikawa K,Nagai T,Miyawaki A,Häusser M,Mikoshiba K

更新日期：2011-09-29 00:00:00

abstract：:Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 and CaV2.2 types. Entering Ca2+ diffuses to a nearby calcium sensor associated with a docked synaptic vesicle (SV) and initiate...

journal_title：Frontiers in cellular neuroscience

authors： Snidal CA,Li Q,Elliott BB,Mah HK,Chen RHC,Gardezi SR,Stanley EF

更新日期：2018-05-11 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:Inflammatory cells may contribute to secondary brain injury following cerebral ischemia. The C57Bl/6 mouse strain is known to exhibit a T helper 1-prone, pro-inflammatory type response to injury, whereas the FVB strain is relatively T helper 2-prone, or anti-inflammatory, in its immune response. We tested whether stro...

journal_title：Frontiers in cellular neuroscience

authors： Kim HA,Whittle SC,Lee S,Chu HX,Zhang SR,Wei Z,Arumugam TV,Vinh A,Drummond GR,Sobey CG

更新日期：2014-11-19 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental ...

journal_title：Frontiers in cellular neuroscience

authors： Lee KM,Coelho MA,McGregor HA,Solton NR,Cohen M,Szumlinski KK

更新日期：2016-11-18 00:00:00

abstract：:Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS). Genome-wide association studies in humans have associated ADCY3 with major depressive disorder and autistic spectrum disorder, both of which exhibit sexual dimorphism. To date, it is ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou Y,Qiu L,Sterpka A,Wang H,Chu F,Chen X

更新日期：2019-02-13 00:00:00

abstract：:Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels...

journal_title：Frontiers in cellular neuroscience

authors： Albertson AJ,Bohannon AS,Hablitz JJ

更新日期：2017-04-19 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson's disease (PD), which is characterized by the DA deficiency due to the dopaminergic neurons loss in the substanti...

journal_title：Frontiers in cellular neuroscience

authors： Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

更新日期：2018-11-13 00:00:00

abstract：:Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known. The GluK2 subunit was recently shown to coexist in a functional complex with the neuronal K-Cl cotransporter KCC2. Apart ...

journal_title：Frontiers in cellular neuroscience

authors： Kesaf S,Khirug S,Dinh E,Saez Garcia M,Soni S,Orav E,Delpire E,Taira T,Lauri SE,Rivera C

更新日期：2020-08-26 00:00:00

abstract：:IN ADULT MAMMALS, UNDER PHYSIOLOGICAL CONDITIONS, NEUROGENESIS, THE PROCESS OF GENERATING NEW FUNCTIONAL NEURONS FROM PRECURSOR CELLS, OCCURS MAINLY IN TWO BRAIN AREAS: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taki...

journal_title：Frontiers in cellular neuroscience

authors： Falcão AM,Marques F,Novais A,Sousa N,Palha JA,Sousa JC

更新日期：2012-08-09 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity. Glial cells can produce and release neurotransmitter-like molec...

journal_title：Frontiers in cellular neuroscience

authors： Van Horn MR,Sild M,Ruthazer ES

更新日期：2013-04-23 00:00:00

abstract：:Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by ...

journal_title：Frontiers in cellular neuroscience

authors： Li L,Xu L,Chen W,Li X,Xia Q,Zheng L,Duan Q,Zhang H,Zhao Y

更新日期：2018-10-11 00:00:00

abstract：:Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction. Additionally, the neuromodulator adenosine has been shown to affect certain ASD como...

journal_title：Frontiers in cellular neuroscience

authors： Shen HY,Huang N,Reemmer J,Xiao L

更新日期：2018-12-07 00:00:00

abstract：:Alzheimer disease is characterized by a progressive cognitive deficit and may be associated with an aberrant hyperexcitability of the neuronal network. Notoginsenoside R1 (R1), a major activity ingredient from Panax notoginseng, has demonstrated favorable changes in neuronal plasticity and induced neuroprotective effe...

journal_title：Frontiers in cellular neuroscience

authors： Hu T,Li S,Liang WQ,Li SS,Lu MN,Chen B,Zhang L,Mao R,Ding WH,Gao WW,Chen SW,XiYang YB,Zhang J,Wang XY

更新日期：2020-09-04 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:Schizophrenia affects more than 1% of the world's population and shows very high heterogeneity in the positive, negative, and cognitive symptoms experienced by patients. The pathogenic mechanisms underlying this neurodevelopmental disorder are largely unknown, although it is proposed to emerge from multiple genetic an...

journal_title：Frontiers in cellular neuroscience

authors： Carrier M,Guilbert J,Lévesque JP,Tremblay MÈ,Desjardins M

更新日期：2021-01-15 00:00:00

abstract：:The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

journal_title：Frontiers in cellular neuroscience

authors： Magalhães AC,Rivera C

更新日期：2016-08-17 00:00:00

abstract：:Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding of SCI has certainly increased during the last decade, but remains far from clear. SCI consists ...

journal_title：Frontiers in cellular neuroscience

authors： Anwar MA,Al Shehabi TS,Eid AH

更新日期：2016-04-13 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinerg...

journal_title：Frontiers in cellular neuroscience

authors： Latina V,Caioli S,Zona C,Ciotti MT,Amadoro G,Calissano P

更新日期：2017-03-15 00:00:00

abstract：:Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral ischemic injury. In this work, we explored whether NT-1 can be steadily overexpressed by adeno-associated virus (AAV) and the exogenous NT-1 can promote neural stem cells...

journal_title：Frontiers in cellular neuroscience

authors： Lu H,Song X,Wang F,Wang G,Wu Y,Wang Q,Wang Y,Yang GY,Zhang Z

更新日期：2016-09-30 00:00:00

abstract：:Magnocellular neurons in the supraoptic nucleus (SON), which synthesize and release arginine vasopressin (AVP) and oxytocin (OT), express several subtypes of ATP-stimulated purinergic P2X receptors (P2XR) that modulate neuronal activity as well as neurotransmitter and hormone release. However, the physiological impact...

journal_title：Frontiers in cellular neuroscience

authors： Ivetic M,Bhattacharyya A,Zemkova H

更新日期：2019-06-26 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) result from striatal dopamine (DA) deficiency due to a progressive degeneration of nigral dopaminergic cells. Although DA replacement therapy is the mainstay to treat parkinsonian symptoms, a long-term daily administration of levodopa often develops levodopa-induced dyski...

journal_title：Frontiers in cellular neuroscience

authors： Goto S

更新日期：2017-11-21 00:00:00