Epigenetic Modifications Associated to Neuroinflammation and Neuropathic Pain After Neural Trauma.

abstract：:Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the...

journal_title：Frontiers in cellular neuroscience

authors： Goel P,Nishimura S,Chetlapalli K,Li X,Chen C,Dickman D

更新日期：2020-06-26 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer, and integrate into neural networks encoding spatial and contextu...

journal_title：Frontiers in cellular neuroscience

authors： Belarbi K,Rosi S

更新日期：2013-09-06 00:00:00

abstract：:Synaptic transmission and its activity-dependent modulation, known as synaptic plasticity, are fundamental processes in nervous system function. Neurons may receive thousands of synaptic contacts, but synaptic regulation may occur only at individual or discrete subsets of synapses, which may have important consequence...

journal_title：Frontiers in cellular neuroscience

authors： Lines J,Covelo A,Gómez R,Liu L,Araque A

更新日期：2017-11-23 00:00:00

abstract：:The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711-729). Four main currents were shown to be involved, namely a persistent sodium current (I(Na-p)), an h current (I(h)), an SK-type calcium-dependent potassium current (I(K-AHP)), and a slow M-like potassium cur...

journal_title：Frontiers in cellular neuroscience

authors： Solinas S,Forti L,Cesana E,Mapelli J,De Schutter E,D'Angelo E

更新日期：2007-12-30 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:The GABAB receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in a number of disorders including multiple sclerosis (MS), but its precise mechanism of action is unknown. Neuroinflammation drives the central pathology in MS and is mediated by both immunoreactive glial cells a...

journal_title：Frontiers in cellular neuroscience

authors： Crowley T,Fitzpatrick JM,Kuijper T,Cryan JF,O'Toole O,O'Leary OF,Downer EJ

更新日期：2015-07-28 00:00:00

abstract：:GABAergic plasticity is recognized as a key mechanism of shaping the activity of the neuronal networks. However, its description is challenging because of numerous neuron-specific mechanisms. In particular, while essential role of glial cells in the excitatory plasticity is well established, their involvement in GABAe...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor PT,Mozrzymas JW

更新日期：2017-05-16 00:00:00

abstract：:Background: Accumulation of amyloid β (Aβ) is one of the main hallmarks of Alzheimer's disease (AD). The enhancement of Aβ clearance may provide therapeutic means to restrict AD pathology. The cellular responses to different forms of Aβ in monocytic cells are poorly known. We aimed to study whether different forms of ...

journal_title：Frontiers in cellular neuroscience

authors： Savchenko E,Malm T,Konttinen H,Hämäläinen RH,Guerrero-Toro C,Wojciechowski S,Giniatullin R,Koistinaho J,Magga J

更新日期：2016-12-05 00:00:00

abstract：:Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in ...

journal_title：Frontiers in cellular neuroscience

authors： Dagostin AA,Lovell PV,Hilscher MM,Mello CV,Leão RM

更新日期：2015-12-10 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals. A focus in our laboratory for over 25 years has been how production of the pregnane neurosteroid, allopregnanolone, is regulated and the novel (i.e...

journal_title：Frontiers in cellular neuroscience

authors： Frye CA,Koonce CJ,Walf AA

更新日期：2014-04-09 00:00:00

abstract：:Distal astrocytic processes have a complex morphology, reminiscent of branchlets and leaflets. Astrocytic branchlets are rod-like processes containing mitochondria and endoplasmic reticulum, capable of generating inositol-3-phosphate (IP3)-dependent Ca2+ signals. Leaflets are small and flat processes that protrude fro...

journal_title：Frontiers in cellular neuroscience

authors： Gavrilov N,Golyagina I,Brazhe A,Scimemi A,Turlapov V,Semyanov A

更新日期：2018-08-17 00:00:00

abstract：:Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the sub-ventricular zone (SVZ) of the lateral ventricles (LV). SGZ newborn neurons are destined to the granular cell layer (GCL) of the DG, while ne...

journal_title：Frontiers in cellular neuroscience

authors： Bátiz LF,Castro MA,Burgos PV,Velásquez ZD,Muñoz RI,Lafourcade CA,Troncoso-Escudero P,Wyneken U

更新日期：2016-01-19 00:00:00

abstract：:The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by progressive muscle weakness and spasticity, remains largely unknown. Approximately 5-10% of cases are familial, and of those, 15-20% are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). ...

journal_title：Frontiers in cellular neuroscience

authors： Juranek JK,Daffu GK,Geddis MS,Li H,Rosario R,Kaplan BJ,Kelly L,Schmidt AM

更新日期：2016-05-09 00:00:00

abstract：:The importance of leucine-rich repeat kinase 2 (LRRK2) to mature neurons is well-established, since mutations in PARK8, the gene encoding LRRK2, are the most common known cause of Parkinson's disease. Nonetheless, despite the LRRK2 knockout mouse having no overt neurodevelopmental defect, numerous lines of in vitro da...

journal_title：Frontiers in cellular neuroscience

authors： Berwick DC,Harvey K

更新日期：2013-05-31 00:00:00

abstract：:Microglia are the resident immune cells of the brain and react quickly to changes in their environment with transcriptional regulation and morphological changes. Brain tissue injury such as ischemic stroke induces a local inflammatory response encompassing microglial activation. The change in activation status of a mi...

journal_title：Frontiers in cellular neuroscience

authors： Heindl S,Gesierich B,Benakis C,Llovera G,Duering M,Liesz A

更新日期：2018-04-19 00:00:00

abstract：:P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response. P2X receptors constitute a gene family of calcium-permeable ATP-gated cation channels therefore the regulation of P2X signaling is critical for both membran...

journal_title：Frontiers in cellular neuroscience

authors： Bernier LP,Ase AR,Séguéla P

更新日期：2013-11-25 00:00:00

abstract：:Gene knockout by homologous recombination is a popular method to study gene functions in the mouse in vivo. However, its lack of temporal control has limited the interpretation of knockout studies because the complete elimination of a gene product often alters developmental processes, and can induce severe malformatio...

journal_title：Frontiers in cellular neuroscience

authors： Heitz F,Johansson T,Baumgärtel K,Gecaj R,Pelczar P,Mansuy IM

更新日期：2014-03-19 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:Behavioral and electrophysiological studies of Alzheimer's disease (AD) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. Re...

journal_title：Frontiers in cellular neuroscience

authors： Erez H,Shemesh OA,Spira ME

更新日期：2014-02-10 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/...

journal_title：Frontiers in cellular neuroscience

authors： Metaxas A,Thygesen C,Briting SRR,Landau AM,Darvesh S,Finsen B

更新日期：2019-12-05 00:00:00

abstract：:Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are believed to represent the different outcomes of a common pathogenic mechanism. However, while researchers have intensely studied the involvement of motor neurons in the ALS/FTD syndrome, very little is known about the function of hippocampal neu...

journal_title：Frontiers in cellular neuroscience

authors： Radzicki D,Liu E,Deng HX,Siddique T,Martina M

更新日期：2016-09-20 00:00:00

abstract：:In this review, we discuss molecular and cellular mechanisms important for the function of neuronal progenitors during development, revealed by their perturbation in different cortical malformations. We focus on a class of neuronal progenitors, radial glial cells (RGCs), which are renowned for their unique morphologic...

journal_title：Frontiers in cellular neuroscience

authors： Bizzotto S,Francis F

更新日期：2015-02-12 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates unfolded protein response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Carboxyl Terminus HSP...

journal_title：Frontiers in cellular neuroscience

authors： Cabral Miranda F,Adão-Novaes J,Hauswirth WW,Linden R,Petrs-Silva H,Chiarini LB

更新日期：2015-01-09 00:00:00

abstract：:Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major lim...

journal_title：Frontiers in cellular neuroscience

authors： Mohamud Yusuf A,Hagemann N,Schulten S,Rausch O,Wagner K,Hussner T,Qi Y,Totzeck M,Kleinschnitz C,Squire A,Gunzer M,Hermann DM

更新日期：2021-01-05 00:00:00

abstract：:Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated syn...

journal_title：Frontiers in cellular neuroscience

authors： Czéh B,Vardya I,Varga Z,Febbraro F,Csabai D,Martis LS,Højgaard K,Henningsen K,Bouzinova EV,Miseta A,Jensen K,Wiborg O

更新日期：2018-06-20 00:00:00